KEGG   ENZYME: 1.13.11.40Help
Entry
EC 1.13.11.40               Enzyme                                 

Name
arachidonate 8-lipoxygenase;
8-lipoxygenase;
8(R)-lipoxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
arachidonate:oxygen 8-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate [RN:R01594]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate [CPD:C04822]
Comment
From the coral Pseudoplexaura porosa.
History
EC 1.13.11.40 created 1989
Pathway
Arachidonic acid metabolism
Reference
1  [PMID:2867091]
  Authors
Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ.
  Title
Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa.
  Journal
J. Biol. Chem. 261 (1986) 747-51.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
100900-72-9

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