| Entry |
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| Name |
acireductone dioxygenase (Ni2+-requiring);
ARD;
2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous);
acireductone dioxygenase (ambiguous);
E-2
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| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
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| Sysname |
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)
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| Reaction(IUBMB) |
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO [RN: R07363]
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| Reaction(KEGG) |
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| Substrate |
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one [CPD: C15606];
O2 [CPD: C00007]
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| Product |
3-(methylthio)propanoate;
formate [CPD: C00058];
CO [CPD: C00237]
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| Comment |
Requires Ni2+. If iron(II) is bound instead of Ni2+, the reaction catalysed by EC 1.13.11.54, acireductone dioxygenase [iron(II)-requiring], occurs instead [1]. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway.
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| Pathway |
| Cysteine and methionine metabolism | | Metabolic pathways |
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| Orthology |
| 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | HMG: | | AQU: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | PGR: | | MBR: | | NGR: | | DDI: | | DPP: | | TET: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | TPS: | | YPP: | | YPG: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | DDA: | | DDC: | | DDD: | | DZE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | ROR: | | XFA: | | XFT: | | XFM: | | XFN: | | XFF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | AVN: | | AVL: | | AVD: | | PSM: | | MAQ: | | MHC: | | MAD: | | MCA: | | MMT: | | MAH: | | NHL: | | NWA: | | TGR: | | HCH: | | ABO: | | ADI: | | TOL: | | AFE: | | AFR: | | ACU: | | AFI: | | DAC: | | DEL: | | RGE: | | DSU: | | CCX: | | SUR: | | SCL: | | HOH: | | PLA: | | BBT: | | RPA: | | RPT: | | SCH: | | GOX: | | GOH: | | GBE: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | AZL: | | ALI: | | ABS: | | TMO: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BPU: | | BPF: | | BMQ: | | BMD: | | BJS: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | ESI: | | EAT: | | EAN: | | BBE: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | TCO: | | AAC: | | AAD: | | SAY: | | SAP: | | NFA: | | NBR: | | SMA: | | SCB: | | SCT: | | SCY: | | MTS: | | FRI: | | FAL: | | FSY: | | SEN: | | AMI: | | SESP: | | AYM: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | TPX: | | HHY: | | SGN: | | FTE: | | PSL: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | SYP: | | MAR: | | CYP: | | CYC: | | CYH: | | CYJ: | | CGC: | | CAN: | | CSN: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMT: | | PMF: | | TER: | | GEI: | | ONI: | | MIC: | | ARP: | | CTHE: | | PLP: | | SCS: | | AAE: | | HYA: | | HHO: | | HYS: | | HTH: | | HTE: | | SUL: | | SAF: | | PMX: | | LFC: | | LFI: | | MOX: | |
» show all
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| Reference |
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| Authors |
Wray JW, Abeles RH. |
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| Title |
A bacterial enzyme that catalyzes formation of carbon monoxide. |
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| Journal |
J. Biol. Chem. 268 (1993) 21466-9. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Wray JW, Abeles RH. |
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| Title |
The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases. |
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| Journal |
J. Biol. Chem. 270 (1995) 3147-53. |
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| Organism |
Rattus norvegicus [GN: rno], Klebsiella pneumoniae [GN: kpn] |
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| Reference |
|
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| Authors |
Furfine ES, Abeles RH. |
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| Title |
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae. |
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| Journal |
J. Biol. Chem. 263 (1988) 9598-606. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
|
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| Authors |
Dai Y, Wensink PC, Abeles RH. |
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| Title |
One protein, two enzymes. |
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| Journal |
J. Biol. Chem. 274 (1999) 1193-5. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Mo H, Dai Y, Pochapsky SS, Pochapsky TC. |
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| Title |
1H, 13C and 15N NMR assignments for a carbon monoxide generating metalloenzyme from Klebsiella pneumoniae. |
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| Journal |
J. Biomol. NMR. 14 (1999) 287-8. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Dai Y, Pochapsky TC, Abeles RH. |
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| Title |
Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae. |
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| Journal |
Biochemistry. 40 (2001) 6379-87. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Al-Mjeni F, Ju T, Pochapsky TC, Maroney MJ. |
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| Title |
XAS investigation of the structure and function of Ni in acireductone dioxygenase. |
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| Journal |
Biochemistry. 41 (2002) 6761-9. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Pochapsky TC, Pochapsky SS, Ju T, Mo H, Al-Mjeni F, Maroney MJ. |
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| Title |
Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae. |
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| Journal |
Nat. Struct. Biol. 9 (2002) 966-72. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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