KEGG   ENZYME: 1.13.11.58Help
Entry
EC 1.13.11.58               Enzyme                                 

Name
linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen 9S-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD:C14827]
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
History
EC 1.13.11.58 created 2011
Pathway
Linoleic acid metabolism
Orthology
K15718  
linoleate 9S-lipoxygenase
Genes
ATH: 
AT1G55020(LOX1) AT3G22400(LOX5)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0057299.1(Lj0g3v0057299.1) Lj0g3v0057299.2(Lj0g3v0057299.2) Lj0g3v0126519.1(Lj0g3v0126519.1) Lj0g3v0177819.1(Lj0g3v0177819.1) Lj0g3v0255679.1(Lj0g3v0255679.1) Lj0g3v0342749.1(Lj0g3v0342749.1) Lj0g3v0342759.1(Lj0g3v0342759.1) Lj1g3v4931510.1(Lj1g3v4931510.1) Lj3g3v0323570.1(Lj3g3v0323570.1) Lj3g3v0323580.1(Lj3g3v0323580.1) Lj3g3v0324640.1(Lj3g3v0324640.1) Lj3g3v0335680.1(Lj3g3v0335680.1) Lj3g3v0335690.1(Lj3g3v0335690.1) Lj3g3v2659870.1(Lj3g3v2659870.1) Lj3g3v2661200.1(Lj3g3v2661200.1) Lj3g3v2662050.1(Lj3g3v2662050.1) Lj3g3v2662120.1(Lj3g3v2662120.1) Lj5g3v2056200.1(Lj5g3v2056200.1) Lj5g3v2056200.2(Lj5g3v2056200.2) Lj5g3v2056200.3(Lj5g3v2056200.3)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4333818(LOX3) 4333821(LOX4) 4333823(LOX5) 4334049(LOX1.1) 4350766
DOSA: 
Os03t0699700-01(Os03g0699700) Os03t0700700-01(Os03g0700700) Os03t0738600-01(Os03g0738600) Os11t0575600-01(Os11g0575600)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g011040(SORBIDRAFT_01g011040) SORBI_01g011050(SORBIDRAFT_01g011050) SORBI_03g042440(SORBIDRAFT_03g042440) SORBI_03g042450(SORBIDRAFT_03g042450) SORBI_06g031350(SORBIDRAFT_06g031350)
ZMA: 
100037802(LOX2) 100037803(LOX4) 100037804(LOX5) 100037805(lox6) 541856(LOX) 542495
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
 » show all
Taxonomy
Reference
1  [PMID:17369372]
  Authors
Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C
  Title
Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral  root development and defense responses through a specific signaling cascade.
  Journal
Plant. Cell. 19 (2007) 831-46.
  Sequence
Reference
2  [PMID:18795358]
  Authors
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR
  Title
Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
  Journal
Lipids. 43 (2008) 979-87.
Reference
3  [PMID:19037675]
  Authors
Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I
  Title
On the substrate binding of linoleate 9-lipoxygenases.
  Journal
Lipids. 44 (2009) 207-15.
  Sequence
[ath:AT1G55020] [ag:AAB31252]
Reference
4  [PMID:18949503]
  Authors
Bannenberg G, Martinez M, Hamberg M, Castresana C
  Title
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
  Journal
Lipids. 44 (2009) 85-95.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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