KEGG   ENZYME: 1.13.11.6Help
Entry
EC 1.13.11.6                Enzyme                                 
Name
3-hydroxyanthranilate 3,4-dioxygenase;
3-hydroxyanthranilate oxygenase;
3-hydroxyanthranilic acid oxygenase;
3-hydroxyanthranilic oxygenase;
3-hydroxyanthranilic acid oxidase;
3HAO
Class
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
Reaction(IUBMB)
3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde [RN:R02665]
Reaction(KEGG)
Substrate
3-hydroxyanthranilate [CPD:C00632];
O2 [CPD:C00007]
Product
2-amino-3-carboxymuconate semialdehyde [CPD:C04409]
Comment
Requires Fe2+.
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00452  
3-hydroxyanthranilate 3,4-dioxygenase
Genes
HSA: 
23498(HAAO)
PTR: 
737730(HAAO)
PPS: 
100996154(HAAO)
GGO: 
101148006(HAAO)
PON: 
100450425(HAAO)
MCC: 
713101(HAAO)
MMU: 
107766(Haao)
RNO: 
56823(Haao)
CFA: 
611728(HAAO)
AML: 
FCA: 
101092928(HAAO)
BTA: 
510602(HAAO)
SSC: 
100514283(HAAO)
ECB: 
100053689
MDO: 
100033379
SHR: 
100928599(HAAO)
OAA: 
100078929
GGA: 
421396(HAAO)
MGP: 
100543137
TGU: 
100229666(HAAO)
ACS: 
100552208
XLA: 
398998(haao)
XTR: 
448761(haao)
DRE: 
492518(haao)
TRU: 
101074031
OLA: 
101157240
BFO: 
BRAFLDRAFT_216793
CIN: 
100175986
SPU: 
582154
ISC: 
IscW_ISCW007038
CEL: 
CELE_K06A4.5(haao-1)
CBR: 
CBG19288
NVE: 
NEMVE_v1g178517
TAD: 
TRIADDRAFT_24699
AQU: 
100636304 100638104
CME: 
CMF152C
SCE: 
YJR025C(BNA1)
AGO: 
AGOS_ACL127W
ERC: 
Ecym_7384
LTH: 
KLTH0B01364g
PPA: 
PAS_chr2-2_0311
VPO: 
Kpol_1050p41
ZRO: 
ZYRO0G11418g
TPF: 
TPHA_0A04890(TPHA0A04890)
TDL: 
TDEL_0E05010(TDEL0E05010)
DHA: 
DEHA2G23034g
PIC: 
PICST_76205(BNA1)
PGU: 
PGUG_04264
LEL: 
LELG_03286
CAL: 
CaO19.3515(BNA1)
CTP: 
CTRG_00583
CDU: 
CD36_30790
COT: 
CORT_0D04560
YLI: 
YALI0B02852g
CLU: 
CLUG_02449
NCR: 
NCU03282
SMP: 
SMAC_02996
PAN: 
PODANSg09674
TTT: 
THITE_2121012
MTM: 
MYCTH_2294240
MGR: 
MGG_00549
FGR: 
FG07058.1
NHE: 
NECHADRAFT_100032
VAL: 
VDBG_04559
SSL: 
SS1G_04451
NFI: 
NFIA_092850 NFIA_097440
AFM: 
AFUA_2G17450 AFUA_8G04650
AOR: 
AOR_1_538144(AO090023000314)
ANG: 
ANI_1_1110144(An16g08210)
AFV: 
AFLA_079310 AFLA_107300
ACT: 
ACLA_058050 ACLA_076350
PCS: 
Pc20g02370 Pc20g09330
CIM: 
CIMG_02183
CPW: 
CPC735_038540
PBL: 
PAAG_04757
ABE: 
ARB_06509
AJE: 
HCAG_02751
PNO: 
SNOG_04710
ZTR: 
MYCGRDRAFT_40773
TML: 
GSTUM_00008703001
CNE: 
CNB05620
CNB: 
CNBB0170
CGI: 
CGB_A0170C
LBC: 
LACBIDRAFT_241145
MPR: 
MPER_02029
CCI: 
CC1G_06466
SCM: 
SCHCODRAFT_86160
UMA: 
UM05606.1
PGR: 
PGTG_08210
NGR: 
NAEGRDRAFT_65213(AM29)
DDI: 
DDB_G0282743(haao)
DPP: 
DICPUDRAFT_58919
XCC: 
XCC1555(haaO)
XCB: 
XC_2679
XCA: 
xccb100_2705
XCV: 
XCV1645
XCP: 
XCR_1834
XAC: 
XAC1603(haaO)
XAX: 
XACM_1575
XAO: 
XAC29_08085
XOO: 
XOO2424(haaO)
XOM: 
XOO_2302
XOP: 
PXO_00755
XOR: 
XOC_1833
XAL: 
XALc_1752
XCI: 
XCAW_02721(haaO)
SML: 
Smlt3159(nbaC)
SMT: 
Smal_2597
BUJ: 
BurJV3_2610
SMZ: 
SMD_2736(nbaC)
PSU: 
Psesu_1685
PSD: 
DSC_08475
FAU: 
Fraau_0880
RHD: 
R2APBS1_1382
SWD: 
Swoo_1408
KKO: 
Kkor_0380
REU: 
Reut_B5502
RME: 
Rmet_5193
BUR: 
Bcep18194_C7641
BCJ: 
BCAM2130(nbaC)
BPY: 
Bphyt_1471
BUG: 
BC1001_3829
BRH: 
RBRH_03005
BPX: 
BUPH_00404
AXY: 
AXYL_05542(nbaC)
PUT: 
PT7_3611
POL: 
Bpro_5139
MXA: 
MXAN_0919
MFU: 
LILAB_04115
MSD: 
MYSTI_00937
CCX: 
COCOR_00869
SUR: 
STAUR_2725
OAN: 
Oant_4402
BJU: 
BJ6T_20700
SIL: 
SPO1774
SIT: 
TM1040_1592
JAN: 
Jann_1447
SWI: 
Swit_3523
PGV: 
SL003B_1865
BCA: 
BCE_2151
BCX: 
BCA_2149(nbaC)
BCF: 
bcf_10185
BCER: 
BCK_24250
BTL: 
BALH_1838
BMQ: 
BMQ_3593(nbaC)
BMD: 
BMD_3578(nbaC)
GTN: 
GTNG_3157(nbaC)
BBE: 
BBR47_29720
RER: 
RER_04730 RER_59360
REQ: 
REQ_05070
SCB: 
SCAB_15161
SSX: 
SACTE_4111
KFL: 
Kfla_5491
SRO: 
Sros_9110
FRI: 
FraEuI1c_1243
STP: 
Strop_3522
SAQ: 
Sare_3897
MAU: 
Micau_4935
MIL: 
ML5_3360
VMA: 
VAB18032_28731
ABA: 
Acid345_0683
CTM: 
Cabther_A1397
CMR: 
Cycma_1684
BBD: 
Belba_0756
EVI: 
Echvi_1448
CHU: 
CHU_3382(nbaC)
FLI: 
Fleli_2019
MTT: 
Ftrac_2832
GFO: 
GFO_3400
FJO: 
Fjoh_1221
FPS: 
FP2235(haaO)
FBR: 
FBFL15_0559(haaO)
FCO: 
FCOL_13115
FIN: 
KQS_12965(haaO)
RBI: 
RB2501_07695
ZPR: 
ZPR_0297
CAT: 
CA2559_02445
FBC: 
FB2170_06825
CAO: 
Celal_1228
CLY: 
Celly_1127
KDI: 
Krodi_1278
LAN: 
Lacal_1459
ZGA: 
zobellia_1477(nbaC)
MRS: 
Murru_1165
ASL: 
Aeqsu_1099
PTQ: 
P700755_001988
NDO: 
DDD_1705
POM: 
MED152_12779(haaO)
FTE: 
Fluta_2018
OHO: 
Oweho_2638
 » show all
Taxonomy
Reference
1  [PMID:13884755]
  Authors
DECKER RH, KANG HH, LEACH FR, HENDERSON LM.
  Title
Purification and properties of 3-hydroxyanthranilic acid oxidase.
  Journal
J. Biol. Chem. 236 (1961) 3076-82.
  Organism
Bos taurus [GN:bta]
Reference
2
  Authors
Hayaishi, O.
  Title
Direct oxygenation by O2, oxygenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-50-9
DBGET integrated database retrieval system