KEGG   ENZYME: 1.13.11.75Help
Entry
EC 1.13.11.75               Enzyme                                 

Name
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase;
Diox1;
ACO;
8'-apo-beta-carotenal 15,15'-oxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
all-trans-8'-apo-beta-carotenal:oxygen 15,15'-oxidoreductase (bond-cleaving)
Reaction(IUBMB)
all-trans-8'-apo-beta-carotenal + O2 = all-trans-retinal + (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial [RN:R09601]
Reaction(KEGG)
Substrate
all-trans-8'-apo-beta-carotenal [CPD:C19728];
O2 [CPD:C00007]
Product
all-trans-retinal [CPD:C00376];
(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial [CPD:C19729]
Comment
Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2].
History
EC 1.13.11.75 created 2010 as EC 1.14.99.41, transferred 2013 to EC 1.13.11.75
Orthology
K00464  
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase
Genes
CRE: 
VCN: 
OLU: 
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SYN: 
SYZ: 
SYY: 
SYNGTS_1854(sll1541)
SYT: 
SYNGTI_1854(sll1541)
SYS: 
SYNPCCN_1853(sll1541)
SYQ: 
SYNPCCP_1853(sll1541)
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THN: 
NK55_09420(diox1)
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GLJ: 
GKIL_0836(diox1)
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 » show all
Taxonomy
Reference
1  [PMID:15686550]
  Authors
Ruch S, Beyer P, Ernst H, Al-Babili S
  Title
Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803.
  Journal
Mol. Microbiol. 55 (2005) 1015-24.
  Sequence
[syn:sll1541]
Reference
2  [PMID:15821095]
  Authors
Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE
  Title
The structure of a retinal-forming carotenoid oxygenase.
  Journal
Science. 308 (2005) 267-9.
  Sequence
[syn:sll1541]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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