KEGG   ENZYME: 1.13.11.77Help
Entry
EC 1.13.11.77               Enzyme                                 

Name
oleate 10S-lipoxygenase;
10S-DOX;
(10S)-dioxygenase;
10S-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
oleate:oxygen (10S)-oxidoreductase
Reaction(IUBMB)
(1) oleate + O2 = (8E,10S)-10-hydroperoxyoctadeca-8-enoate [RN:R10576];
(2) linoleate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate [RN:R10577];
(3) alpha-linolenate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate [RN:R10578]
Reaction(KEGG)
Substrate
oleate [CPD:C00712];
O2 [CPD:C00007];
linoleate [CPD:C01595];
alpha-linolenate [CPD:C06427]
Product
(8E,10S)-10-hydroperoxyoctadeca-8-enoate [CPD:C20702];
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate [CPD:C20703];
(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate [CPD:C20704]
Comment
Binds Fe2+. The enzyme isolated from the bacterium Pseudomonas sp. 42A2 has similar activity with all the three Delta9 fatty acids. cf. EC 1.13.11.62, linoleate 10R-lipoxygenase.
History
EC 1.13.11.77 created 2013
Reference
1  [PMID:15028873]
  Authors
Busquets M, Deroncele V, Vidal-Mas J, Rodriguez E, Guerrero A, Manresa A
  Title
Isolation and characterization of a lipoxygenase from Pseudomonas 42A2 responsible for the biotransformation of oleic acid into ( S )-( E )-10-hydroxy-8-octadecenoic acid.
  Journal
Antonie. Van. Leeuwenhoek. 85 (2004) 129-39.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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