KEGG   ENZYME: 1.13.12.4Help
Entry
EC 1.13.12.4                Enzyme                                 

Name
lactate 2-monooxygenase;
lactate oxidative decarboxylase;
lactate oxidase;
lactic oxygenase;
lactate oxygenase;
lactic oxidase;
L-lactate monooxygenase;
lactate monooxygenase;
L-lactate-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-lactate + O2 = acetate + CO2 + H2O [RN:R00319]
Reaction(KEGG)
Substrate
(S)-lactate [CPD:C00186];
O2 [CPD:C00007]
Product
acetate [CPD:C00033];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FMN).
History
EC 1.13.12.4 created 1961 as EC 1.1.3.2, transferred 1972 to EC 1.13.12.4
Pathway
Pyruvate metabolism
Orthology
K00467  
lactate 2-monooxygenase
Genes
AFM: 
CCR: 
LSA: 
LSA0664(loxL1N) LSA0665(loxL1I) LSA0666(loxL1C)
MAV: 
MSM: 
MMC: 
MKM: 
MJL: 
SEN: 
RXY: 
DGE: 
TTH: 
PTO: 
 » show all
Taxonomy
Reference
1
  Authors
Hayaishi, O. and Sutton, W.B.
  Title
Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L-lactate.
  Journal
J. Am. Chem. Soc. 79 (1957) 4809-4810.
Reference
2  [PMID:13428772]
  Authors
SUTTON WB.
  Title
Mechanism of action and crystallization of lactic oxidative decarboxylase from Mycobacterium phlei.
  Journal
J. Biol. Chem. 226 (1957) 395-405.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-72-2

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