KEGG   ENZYME: 1.14.11.16Help
Entry
EC 1.14.11.16               Enzyme                                 
Name
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Reaction(KEGG)
Substrate
peptide-L-aspartate;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
peptide-3-hydroxy-L-aspartate;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
Orthology
K00476  
aspartate beta-hydroxylase
Genes
HSA: 
444(ASPH) 55662(HIF1AN)
PTR: 
464202(ASPH) 466183(HIF1AN)
PPS: 
100969925(HIF1AN) 100977040(ASPH)
GGO: 
PON: 
MCC: 
699884(ASPH) 710425(HIF1AN)
MMU: 
319594(Hif1an) 65973(Asph)
RNO: 
309434(Hif1an) 312981(Asph)
CFA: 
403846(ASPH) 609221(HIF1AN)
AML: 
FCA: 
101091901(HIF1AN) 101100695(ASPH)
BTA: 
286771(ASPH) 520864(HIF1AN)
SSC: 
100155854(HIF1AN) 100513467 100526167 100736695
ECB: 
100065909(ASPH) 100070337(HIF1AN)
MDO: 
100010508(HIF1AN) 100029689(ASPH)
SHR: 
100923835(ASPH) 100932046(HIF1AN)
OAA: 
100082566(ASPH) 100084505
GGA: 
421142(ASPH) 428952(HIF1AN)
MGP: 
100540272(ASPH) 100547017(HIF1AN)
TGU: 
100224185(HIF1AN) 100231659(ASPH)
ACS: 
100563401(asph) 100564872
XLA: 
100137711(asph) 432095(hif1an)
XTR: 
394511(hif1an) 548451(asph)
DRE: 
373126(hif1an) 559236
TRU: 
101061760 101073285
OLA: 
101156274 101167495
BFO: 
BRAFLDRAFT_203187 BRAFLDRAFT_259568
CIN: 
100179426 100185342
SPU: 
589503 593797
DME: 
Dmel_CG8421(Asph)
DPO: 
Dpse_GA21066
DAN: 
Dana_GF11291
DER: 
Dere_GG20567
DPE: 
Dper_GL20566
DSE: 
Dsec_GM21659
DSI: 
Dsim_GD11159
DWI: 
Dwil_GK21857
DYA: 
Dyak_GE11752
DGR: 
Dgri_GH22068
DMO: 
Dmoj_GI19152
DVI: 
Dvir_GJ22287
AAG: 
AaeL_AAEL005181
TCA: 
656627 664369(Hif1an)
API: 
100162022
PHU: 
Phum_PHUM407110 Phum_PHUM407820
ISC: 
IscW_ISCW011064 IscW_ISCW016886
CEL: 
CELE_K09A9.6(K09A9.6)
CBR: 
CBG07728
BMY: 
Bm1_33860
TSP: 
Tsp_03380
NVE: 
NEMVE_v1g173452 NEMVE_v1g231221
TAD: 
TRIADDRAFT_31864
AQU: 
100639620
OTA: 
Ot10g00170
TET: 
TTHERM_01228990
PIF: 
PITG_03015
SPE: 
Spro_3198
SRR: 
SerAS9_3315
SRS: 
SerAS12_3316
SRA: 
SerAS13_3318
SMW: 
SMWW4_v1c32500
LPN: 
lpg2463
LPF: 
lpl2383
LPP: 
lpp2530
LPC: 
LPC_2013
BMA: 
BMAA0571
BML: 
BMA10229_0896
BMN: 
BMA10247_A1863
BPS: 
BPSS1421
BPM: 
BURPS1710b_A0445
BPL: 
BURPS1106A_A1927
BPD: 
BURPS668_A2019
BPZ: 
BP1026B_II1513
BPQ: 
BPC006_II1907
BTE: 
BTH_II0971
BVI: 
Bcep1808_3464
BUR: 
Bcep18194_B0466
BCN: 
Bcen_3204
BCH: 
Bcen2424_5163
BCM: 
Bcenmc03_5116
BCJ: 
BCAM2401
BAM: 
Bamb_4559
BAC: 
BamMC406_5084
BMU: 
Bmul_3492
BMJ: 
BMULJ_05025(aspH)
BCT: 
GEM_3287
BGL: 
bglu_2g04810
BGD: 
bgla_2g06280
BUK: 
MYA_3088
 » show all
Taxonomy
Reference
1  [PMID:2187868]
  Authors
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA.
  Title
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.
  Journal
J. Biol. Chem. 265 (1990) 8558-65.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122544-66-5
DBGET integrated database retrieval system