KEGG   ENZYME: 1.14.11.16Help
Entry
EC 1.14.11.16               Enzyme                                 

Name
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Reaction(KEGG)
Substrate
peptide-L-aspartate;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
peptide-3-hydroxy-L-aspartate;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
History
EC 1.14.11.16 created 1992
Orthology
K00476  
aspartate beta-hydroxylase
Genes
HSA: 
444(ASPH)
PTR: 
464202(ASPH)
PPS: 
100977040(ASPH)
PON: 
NLE: 
100581524(ASPH)
MCC: 
699884(ASPH)
MCF: 
CJC: 
100403503(ASPH)
MMU: 
65973(Asph)
RNO: 
312981(Asph)
CGE: 
100755768(Asph)
NGI: 
103737741(Asph)
HGL: 
101725986(Asph)
OCU: 
100008743(ASPH)
TUP: 
102478772(ASPH)
CFA: 
403846(ASPH)
AML: 
UMR: 
103677467(ASPH)
FCA: 
101100695(ASPH)
PTG: 
102960536(ASPH)
BTA: 
286771(ASPH)
BOM: 
102285100(ASPH)
PHD: 
102341776(ASPH)
CHX: 
OAS: 
SSC: 
CFR: 
102505456(ASPH)
BACU: 
103017679(ASPH)
LVE: 
103068515(ASPH)
ECB: 
100065909(ASPH) 102148931(ASPH)
MYB: 
102255804(ASPH)
MYD: 
102769038(ASPH)
PALE: 
MDO: 
100029689(ASPH)
SHR: 
100923835(ASPH)
OAA: 
100082566(ASPH)
GGA: 
421142(ASPH)
MGP: 
100540272(ASPH)
APLA: 
101796017(ASPH)
TGU: 
100231659(ASPH)
FAB: 
101809173(ASPH)
PHI: 
102100401(ASPH)
FPG: 
101911221(ASPH)
FCH: 
102046157(ASPH)
CLV: 
102097223(ASPH)
ASN: 
AMJ: 
102573977(ASPH)
PSS: 
102460072(ASPH)
CMY: 
102937266(ASPH)
ACS: 
100563401(asph)
PBI: 
103048046(ASPH)
XLA: 
100137711(asph)
XTR: 
548451(asph)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180766(asph)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AAG: 
CQU: 
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CELE_K09A9.6(K09A9.6)
CBR: 
BMY: 
LOA: 
TSP: 
LGI: 
NVE: 
TAD: 
OTA: 
TET: 
GTT: 
SPE: 
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMW: 
SLQ: 
LPN: 
LPF: 
LPP: 
LPC: 
BMA: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPSU: 
BPZ: 
BPQ: 
BPK: 
BTE: 
BTD: 
BVI: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BAM: 
BAC: 
BMU: 
BMJ: 
BCT: 
BGL: 
BGD: 
BUK: 
MLO: 
 » show all
Taxonomy
Reference
1  [PMID:2187868]
  Authors
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA.
  Title
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.
  Journal
J. Biol. Chem. 265 (1990) 8558-65.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122544-66-5

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