KEGG   ENZYME: 1.14.11.7Help
Entry
EC 1.14.11.7                Enzyme                                 

Name
procollagen-proline 3-dioxygenase;
proline,2-oxoglutarate 3-dioxygenase;
prolyl 3-hydroxylase;
protocollagen proline 3-hydroxylase;
prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2 [RN:R03218]
Reaction(KEGG)
Substrate
procollagen L-proline [CPD:C01078];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
procollagen trans-3-hydroxy-L-proline [CPD:C04397];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.7 created 1981, modified 1983
Reference
1  [PMID:191255]
  Authors
Risteli J, Tryggvason K, Kivirikko KI.
  Title
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex.
  Journal
Eur. J. Biochem. 73 (1977) 485-92.
Reference
2  [PMID:204218]
  Authors
Risteli J, Tryggvason K, Kivirikko KI.
  Title
A rapid assay for prolyl 3-hydroxylase activity.
  Journal
Anal. Biochem. 84 (1978) 423-31.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
63551-75-7

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