KEGG   ENZYME: 1.14.13.132Help
Entry
EC 1.14.13.132              Enzyme                                 
Name
squalene monooxygenase;
squalene epoxidase;
squalene-2,3-epoxide cyclase;
squalene 2,3-oxidocyclase;
squalene hydroxylase;
squalene oxydocyclase;
squalene-2,3-epoxidase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing)
Reaction(IUBMB)
squalene + NADPH + H+ + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O [RN:R02874]
Reaction(KEGG)
R02874;
(other) R02873
Show
Substrate
squalene [CPD:C00751];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor, NADPH, is coupled via EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00511  
squalene monooxygenase
Genes
HSA: 
6713(SQLE)
PTR: 
464383(SQLE)
PPS: 
100976805(SQLE)
GGO: 
101129462(SQLE)
PON: 
MCC: 
706764(SQLE)
MMU: 
20775(Sqle)
RNO: 
29230(Sqle)
CFA: 
608021(SQLE)
AML: 
100465589(SQLE)
FCA: 
101086537(SQLE)
BTA: 
526535(SQLE)
SSC: 
100113409(SQLE)
ECB: 
100067615(SQLE)
MDO: 
100032247(SQLE)
SHR: 
100918180(SQLE)
OAA: 
100076751(SQLE)
GGA: 
420335(SQLE)
MGP: 
100546703(SQLE)
TGU: 
100225604(SQLE)
ACS: 
100557553(sqle)
XTR: 
100491400(sqle)
DRE: 
799528
TRU: 
101073594
OLA: 
101165835
BFO: 
BRAFLDRAFT_288182
SPU: 
763532
TAD: 
TRIADDRAFT_63342
AQU: 
100632870
ATH: 
AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)
ALY: 
ARALYDRAFT_326701 ARALYDRAFT_475389 ARALYDRAFT_490840 ARALYDRAFT_662237 ARALYDRAFT_667512
GMX: 
100795522 100796946 100800329 100804406 100808856 100820031
MTR: 
MTR_4g092640
CSV: 
101204949 101213038
RCU: 
RCOM_0402510 RCOM_0859900 RCOM_1329420 RCOM_1382290 RCOM_1382340 RCOM_1585750
POP: 
POPTR_1107615 POPTR_253298 POPTR_411973 POPTR_573662 POPTR_779996 POPTR_788926 POPTR_831444 POPTR_832433
VVI: 
100254037 100260031 100262930 100265235
OSA: 
4332152 4332153
DOSA: 
Os03t0231700-02(Os03g0231700) Os03t0231800-02(Os03g0231800)
BDI: 
100839945
SBI: 
SORBI_01g042050(SORBIDRAFT_01g042050)
ZMA: 
100274333 100285558(pco148653)
SMO: 
SELMODRAFT_150266
PPP: 
PHYPADRAFT_224792
VCN: 
VOLCADRAFT_74714
OLU: 
OSTLU_88065
OTA: 
Ot08g03100
CME: 
CMH256C
SCE: 
YGR175C(ERG1)
AGO: 
AGOS_AAL141C
ERC: 
Ecym_6016
KLA: 
KLLA0F15224g
LTH: 
KLTH0B03784g
PPA: 
PAS_chr3_0124
VPO: 
Kpol_2002p90
ZRO: 
ZYRO0B10912g
CGR: 
CAGL0D05940g
NCS: 
NCAS_0A06930(NCAS0A06930)
NDI: 
NDAI_0D01990(NDAI0D01990)
TPF: 
TPHA_0E03160(TPHA0E03160)
TBL: 
TBLA_0C05980(TBLA0C05980)
TDL: 
TDEL_0E04440(TDEL0E04440)
KAF: 
KAFR_0D01720(KAFR0D01720)
DHA: 
DEHA2G14300g
PIC: 
PICST_75910(ERG1)
PGU: 
PGUG_04402
LEL: 
LELG_00710
CAL: 
CaO19.406(ERG1) CaO19.8036(ERG1)
CTP: 
CTRG_05483
CDU: 
CD36_08100
COT: 
CORT_0A09800
YLI: 
YALI0E15730g
CLU: 
CLUG_01944
NCR: 
NCU08280
SMP: 
SMAC_00934
PAN: 
PODANSg7130
TTT: 
THITE_2115532
MTM: 
MYCTH_2299088
MGR: 
MGG_06139
FGR: 
FG06215.1
NHE: 
NECHADRAFT_34081
VAL: 
VDBG_01618
SSL: 
SS1G_13084
BFU: 
BC1G_14066
NFI: 
NFIA_079490
AFM: 
AFUA_5G07780
AOR: 
AOR_1_1218114(AO090701000685)
ANG: 
ANI_1_450034(An03g03770)
AFV: 
AFLA_061500
ACT: 
ACLA_012730
PCS: 
Pc22g15550
CIM: 
CIMG_06149
CPW: 
CPC735_027040
PBL: 
PAAG_08773
URE: 
UREG_04240
ABE: 
ARB_06092
TVE: 
TRV_00314
AJE: 
HCAG_02957
PNO: 
SNOG_12929
PTE: 
PTT_17609
ZTR: 
MYCGRDRAFT_108597(ERG1)
TML: 
GSTUM_00004857001
SPO: 
SPBC713.12(erg1)
CNE: 
CND06110
CNB: 
CNBD0290
CGI: 
CGB_I0350C
LBC: 
LACBIDRAFT_190855
MPR: 
MPER_07144 MPER_15678
CCI: 
CC1G_03987
SCM: 
SCHCODRAFT_71339
UMA: 
UM02398.1
MGL: 
MGL_0127
NGR: 
NAEGRDRAFT_78243
DDI: 
DDB_G0293584(sqle)
DPP: 
DICPUDRAFT_49927
TBR: 
Tb11.02.0780
TCR: 
509589.20
LMA: 
LMJF_13_1620
LIF: 
LINJ_13_1360
LDO: 
LDBPK_131360
LMI: 
LMXM_13_1620
LBZ: 
LBRM_13_1480
MAH: 
MEALZ_0767
CCX: 
COCOR_01775(ubiF)
SUR: 
STAUR_5420
FTE: 
Fluta_3221
 » show all
Taxonomy
Reference
1  [PMID:5918046]
  Authors
Cory EJ, Russey WE, Ortiz de Montellano PR.
  Title
2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.
  Journal
J. Am. Chem. Soc. 88 (1966) 4750-1.
Reference
2  [PMID:13438881]
  Authors
TCHEN TT, BLOCH K.
  Title
On the conversion of squalene to lanosterol in vitro.
  Journal
J. Biol. Chem. 226 (1957) 921-30.
Reference
3  [PMID:5918048]
  Authors
Van Tamelen EE, Willett JD, Clayton RB, Lord KE.
  Title
Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.
  Journal
J. Am. Chem. Soc. 88 (1966) 4752-4.
Reference
4  [PMID:5438357]
  Authors
Yamamoto S, Bloch K.
  Title
Studies on squalene epoxidase of rat liver.
  Journal
J. Biol. Chem. 245 (1970) 1670-4.
Reference
5  [PMID:234459]
  Authors
Ono T, Bloch K
  Title
Solubilization and partial characterization of rat liver squalene epoxidase.
  Journal
J. Biol. Chem. 250 (1975) 1571-9.
Reference
6  [PMID:8358382]
  Authors
Satoh T, Horie M, Watanabe H, Tsuchiya Y, Kamei T
  Title
Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
  Journal
Biol. Pharm. Bull. 16 (1993) 349-52.
Reference
7  [PMID:12467639]
  Authors
Chugh A, Ray A, Gupta JB
  Title
Squalene epoxidase as hypocholesterolemic drug target revisited.
  Journal
Prog. Lipid. Res. 42 (2003) 37-50.
Reference
8  [PMID:17852349]
  Authors
He F, Zhu Y, He M, Zhang Y
  Title
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
  Journal
DNA. Seq. 19 (2008) 270-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-62-3
DBGET integrated database retrieval system