KEGG   ENZYME: 1.14.13.132Help
Entry
EC 1.14.13.132              Enzyme                                 

Name
squalene monooxygenase;
squalene epoxidase;
squalene-2,3-epoxide cyclase;
squalene 2,3-oxidocyclase;
squalene hydroxylase;
squalene oxydocyclase;
squalene-2,3-epoxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing)
Reaction(IUBMB)
squalene + NADPH + H+ + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O [RN:R02874]
Reaction(KEGG)
R02874;
(other) R02873
Show
Substrate
squalene [CPD:C00751];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor, NADPH, is coupled via EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
Pathway
Steroid biosynthesis
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00511  
squalene monooxygenase
Genes
HSA: 
6713(SQLE)
PTR: 
464383(SQLE)
PPS: 
100976805(SQLE)
GGO: 
101129462(SQLE)
PON: 
MCC: 
706764(SQLE)
MCF: 
102118907(SQLE)
MMU: 
20775(Sqle)
RNO: 
29230(Sqle)
CGE: 
HGL: 
101709317(Sqle)
TUP: 
102473783(SQLE)
CFA: 
608021(SQLE)
AML: 
100465589(SQLE)
FCA: 
101086537(SQLE)
BTA: 
526535(SQLE)
BOM: 
102264644(SQLE)
PHD: 
102342379(SQLE)
CHX: 
102187506(SQLE)
SSC: 
100113409(SQLE)
CFR: 
102518096(SQLE)
ECB: 
100067615(SQLE)
MYB: 
MDO: 
100032247(SQLE)
SHR: 
100918180(SQLE)
OAA: 
100076751(SQLE)
GGA: 
420335(SQLE)
MGP: 
100546703(SQLE)
TGU: 
100225604(SQLE)
FAB: 
101806873(SQLE)
PHI: 
102109574(SQLE)
APLA: 
101802617(SQLE)
FPG: 
101920264(SQLE)
FCH: 
102054050(SQLE)
CLV: 
102090054(SQLE)
ASN: 
102368291(SQLE)
PSS: 
102444614(SQLE)
ACS: 
100557553(sqle)
XTR: 
100491400(sqle)
DRE: 
799528(sqlea)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
TAD: 
AQU: 
ATH: 
AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0231700-01(Os03g0231700) Os03t0231800-02(Os03g0231800)
BDI: 
SBI: 
SORBI_01g042050(SORBIDRAFT_01g042050)
ZMA: 
100274333 100285558(pco148653)
SITA: 
SMO: 
PPP: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
SCE: 
YGR175C(ERG1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A06930(NCAS0A06930)
NDI: 
NDAI_0D01990(NDAI0D01990)
TPF: 
TPHA_0E03160(TPHA0E03160)
TBL: 
TBLA_0C05980(TBLA0C05980)
TDL: 
TDEL_0E04440(TDEL0E04440)
KAF: 
KAFR_0D01720(KAFR0D01720)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.406(ERG1) CaO19.8036(ERG1)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
NFI: 
AFM: 
AOR: 
AOR_1_1218114(AO090701000685)
ANG: 
ANI_1_450034(An03g03770)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
DDI: 
DPP: 
DFA: 
DFA_07098(sqle)
ACAN: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
MAH: 
CCX: 
SUR: 
FTE: 
 » show all
Taxonomy
Reference
1  [PMID:5918046]
  Authors
Cory EJ, Russey WE, Ortiz de Montellano PR.
  Title
2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.
  Journal
J. Am. Chem. Soc. 88 (1966) 4750-1.
Reference
2  [PMID:13438881]
  Authors
TCHEN TT, BLOCH K.
  Title
On the conversion of squalene to lanosterol in vitro.
  Journal
J. Biol. Chem. 226 (1957) 921-30.
Reference
3  [PMID:5918048]
  Authors
Van Tamelen EE, Willett JD, Clayton RB, Lord KE.
  Title
Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.
  Journal
J. Am. Chem. Soc. 88 (1966) 4752-4.
Reference
4  [PMID:5438357]
  Authors
Yamamoto S, Bloch K.
  Title
Studies on squalene epoxidase of rat liver.
  Journal
J. Biol. Chem. 245 (1970) 1670-4.
Reference
5  [PMID:234459]
  Authors
Ono T, Bloch K
  Title
Solubilization and partial characterization of rat liver squalene epoxidase.
  Journal
J. Biol. Chem. 250 (1975) 1571-9.
Reference
6  [PMID:8358382]
  Authors
Satoh T, Horie M, Watanabe H, Tsuchiya Y, Kamei T
  Title
Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
  Journal
Biol. Pharm. Bull. 16 (1993) 349-52.
Reference
7  [PMID:12467639]
  Authors
Chugh A, Ray A, Gupta JB
  Title
Squalene epoxidase as hypocholesterolemic drug target revisited.
  Journal
Prog. Lipid. Res. 42 (2003) 37-50.
Reference
8  [PMID:17852349]
  Authors
He F, Zhu Y, He M, Zhang Y
  Title
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
  Journal
DNA. Seq. 19 (2008) 270-3.
  Organism
Panax notoginseng
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-62-3

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