| Entry |
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| Name |
4-hydroxybenzoate 3-monooxygenase;
p-hydroxybenzoate hydrolyase;
p-hydroxybenzoate hydroxylase;
4-hydroxybenzoate 3-hydroxylase;
4-hydroxybenzoate monooxygenase;
4-hydroxybenzoic hydroxylase;
p-hydroxybenzoate-3-hydroxylase;
p-hydroxybenzoic acid hydrolase;
p-hydroxybenzoic acid hydroxylase;
p-hydroxybenzoic hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O [RN: R01298]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). Most enzymes from Pseudomonas are highly specific for NADPH (cf. EC 1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]).
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| Pathway |
| Benzoate degradation | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| p-hydroxybenzoate 3-monooxygenase |
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| Genes |
EFE: | | EBI: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOR: | | XAL: | | XCI: | | VEJ: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PSA: | | PSZ: | | PSR: | | PBA: | | PFV: | | PDR: | | AVN: | | AVL: | | AVD: | | ACI: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ACC: | | PAT: | | CSA: | | HEL: | | MMW: | | MME: | | MPC: | | OCE: | | RSO: | | RSC: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | RFR: | | POL: | | PNA: | | ACK: | | VEI: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | RTA: | | HSE: | | CFU: | | LCH: | | AZO: | | SUR: | | MLO: | | MCI: | | MOP: | | MES: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMC: | | BAA: | | BMS: | | BSI: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPD: | | RPE: | | RPT: | | RPX: | | AOL: | | XAU: | | AZC: | | MET: | | MNO: | | PHL: | | CCR: | | CCS: | | CAK: | | CSE: | | BSB: | | SIL: | | SIT: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | KVU: | | KVL: | | PSF: | | PGA: | | PGL: | | NAR: | | NPP: | | SCH: | | SSY: | | ACR: | | AMV: | | MAG: | | AZL: | | ALI: | | TMO: | | APB: | | PGV: | | BLI: | | BLD: | | BPF: | | AAC: | | AAD: | | CGL: | | CGB: | | CGU: | | CGT: | | CEF: | | CHN: | | CCN: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GPO: | | SCO: | | SMA: | | SCB: | | SVL: | | SCT: | | SCY: | | SBH: | | SHY: | | SHO: | | SDV: | | KSK: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | MPH: | | TCU: | | SRO: | | FRI: | | FSY: | | NML: | | GOB: | | BSD: | | MMAR: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | VMA: | | AMS: | | ASE: | | CAI: | | RXY: | | TSA: | | SUS: | | CPI: | | HHY: | | SLI: | | RSI: | | EOL: | | STI: | | DGE: | | TTL: | | TSC: | | THC: | | TOS: | | MRB: | | MRE: | | HMA: | |
» show all
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| Reference |
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| Authors |
Hosokawa K, Stanier RY. |
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| Title |
Crystallization and properties of p-hydroxybenzoate hydroxylase from Pseudomonas putida. |
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| Journal |
J. Biol. Chem. 241 (1966) 2453-60. |
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| Organism |
Pseudomonas putida |
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| Reference |
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| Authors |
Howell LG, Spector T, Massey V. |
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| Title |
Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. |
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| Journal |
J. Biol. Chem. 247 (1972) 4340-50. |
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| Organism |
Pseudomonas fluorescens |
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| Reference |
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| Authors |
Spector T, Massey V. |
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| Title |
Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. |
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| Journal |
J. Biol. Chem. 247 (1972) 4679-87. |
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| Organism |
Pseudomonas fluorescens |
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| Reference |
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| Authors |
Spector T, Massey V. |
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| Title |
p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate. |
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| Journal |
J. Biol. Chem. 247 (1972) 5632-6. |
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| Organism |
Pseudomonas fluorescens |
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| Reference |
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| Authors |
Spector T, Massey V. |
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| Title |
p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Reactivity with oxygen. |
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| Journal |
J. Biol. Chem. 247 (1972) 7123-7. |
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| Organism |
Pseudomonas fluorescens |
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| Reference |
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| Authors |
Seibold B, Matthes M, Eppink MH, Lingens F, Van Berkel WJ, Muller R. |
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| Title |
4-Hydroxybenzoate hydroxylase from Pseudomonas sp. CBS3. Purification, characterization, gene cloning, sequence analysis and assignment of structural features determining the coenzyme specificity. |
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| Journal |
Eur. J. Biochem. 239 (1996) 469-78. |
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| Organism |
Pseudomonas sp. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9059-23-8 |
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