KEGG   ENZYME: 1.14.13.32Help
Entry
EC 1.14.13.32               Enzyme                                 

Name
albendazole monooxygenase;
albendazole oxidase;
albendazole sulfoxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
Reaction(IUBMB)
albendazole + NADPH + H+ + O2 = albendazole S-oxide + NADP+ + H2O [RN:R03712]
Reaction(KEGG)
Substrate
albendazole [CPD:C01779];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
albendazole S-oxide [CPD:C02809];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.32 created 1989
Orthology
K17689  
cytochrome P450, family 3, subfamily A, polypeptide 4
Genes
HSA: 
1576(CYP3A4)
PTR: 
463582(CYP3A4)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
678670(CYP3A4)
MCF: 
102144258(CYP3A8)
CSAB: 
RRO: 
TUP: 
CFA: 
479740(CYP3A4)
 » show all
Taxonomy
Reference
1  [PMID:3739217]
  Authors
Fargetton X, Galtier P, Delatour P.
  Title
Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes.
  Journal
Vet. Res. Commun. 10 (1986) 317-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
101299-59-6

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