KEGG   ENZYME: 1.14.13.67Help
Entry
EC 1.14.13.67               Enzyme                                 

Name
quinine 3-monooxygenase;
quinine 3-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
quinine,NADPH:oxygen oxidoreductase
Reaction(IUBMB)
quinine + NADPH + H+ + O2 = 3-hydroxyquinine + NADP+ + H2O [RN:R05727]
Reaction(KEGG)
Substrate
quinine [CPD:C06526];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3-hydroxyquinine [CPD:C07344];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
History
EC 1.14.13.67 created 2000
Orthology
K17689  
cytochrome P450, family 3, subfamily A, polypeptide 4
Genes
HSA: 
1576(CYP3A4)
PTR: 
463582(CYP3A4)
PPS: 
GGO: 
PON: 
MCC: 
678670(CYP3A4)
MCF: 
102144258(CYP3A8)
RRO: 
TUP: 
CFA: 
479740(CYP3A4)
Taxonomy
Reference
1  [PMID:1578365]
  Authors
Relling MV, Evans R, Dass C, Desiderio DM, Nemec J.
  Title
Human cytochrome P450 metabolism of teniposide and etoposide.
  Journal
J. Pharmacol. Exp. Ther. 261 (1992) 491-6.
Reference
2  [PMID:9088578]
  Authors
Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S.
  Title
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.
  Journal
Br. J. Clin. Pharmacol. 43 (1997) 245-52.
  Sequence
[hsa:1576]
Reference
3  [PMID:9456308]
  Authors
Zhao XJ, Kawashiro T, Ishizaki T.
  Title
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
  Journal
Drug. Metab. Dispos. 26 (1998) 188-91.
  Sequence
[hsa:1576]
Reference
4  [PMID:8968357]
  Authors
Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.
  Title
Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
  Journal
J. Pharmacol. Exp. Ther. 279 (1996) 1327-34.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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