KEGG   ENZYME: 1.14.13.7Help
Entry
EC 1.14.13.7                Enzyme                                 
Name
phenol 2-monooxygenase;
phenol hydroxylase;
phenol o-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O [RN:R00815]
Reaction(KEGG)
Substrate
phenol [CPD:C00146];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also active with resorcinol and 2-methylphenol.
Pathway
Chlorocyclohexane and chlorobenzene degradation
Toluene degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K03380  
phenol 2-monooxygenase
Genes
DHA: 
PIC: 
LEL: 
CAL: 
CaO19.11196(PHH2) CaO19.604(PHH1) CaO19.8237(PHH1)
CTP: 
CDU: 
NCR: 
SMP: 
PAN: 
MGR: 
FGR: 
FG09110.1 FG11194.1
NHE: 
NECHADRAFT_64650
SSL: 
SS1G_13313
BFU: 
BC1G_06740
ANI: 
AN0503.2 AN7418.2
NFI: 
NFIA_011840 NFIA_033860 NFIA_057170
AFM: 
AFUA_1G13660 AFUA_2G01580 AFUA_3G02620 AFUA_6G11480
AOR: 
AOR_1_618024(AO090010000367) AOR_1_732144(AO090023000432)
ANG: 
ANI_1_3124014(An01g11800)
AFV: 
AFLA_017760 AFLA_108440 AFLA_118610
ACT: 
ACLA_021780 ACLA_085150
PCS: 
Pc13g05120 Pc13g12480 Pc20g01980
CIM: 
CIMG_10045
CPW: 
CPC735_011900
URE: 
UREG_04222 UREG_05983
ABE: 
ARB_01796
TVE: 
TRV_06545
PNO: 
SNOG_10050
PTE: 
PTT_10340
TML: 
GSTUM_00005736001
PPL: 
POSPLDRAFT_90902
LBC: 
LACBIDRAFT_188035
CCI: 
CC1G_14808 CC1G_14809
SCM: 
SCHCODRAFT_12802 SCHCODRAFT_67592
UMA: 
UM04348.1
MMW: 
Mmwyl1_3129
BPH: 
Bphy_6383
BGE: 
BC1002_6612
BYI: 
BYI23_B006180
CTT: 
CtCNB1_3410
ARA: 
Arad_7218
BJA: 
blr4222
BJU: 
BJ6T_55730
BRA: 
BRADO5224
BBT: 
BBta_5688
BRS: 
S23_40400
MET: 
M446_6872
MNO: 
Mnod_0822 Mnod_3235 Mnod_8211
PHL: 
KKY_2081
PDE: 
Pden_3488
APB: 
SAR116_2504
PGV: 
SL003B_1806
CGL: 
NCgl0050(Cgl0050) NCgl2588(Cgl2681)
CGB: 
cg0070 cg2966
CGT: 
cgR_2584
CAR: 
cauri_2503
NFA: 
nfa27810
GPO: 
GPOL_c33240(mphP2)
MTS: 
MTES_0649
ART: 
Arth_3519
AAU: 
AAur_2032 AAur_pTC20088
ACH: 
Achl_3607
AAI: 
AARI_11920
APN: 
Asphe3_36590
ARR: 
ARUE_c21850
RSA: 
RSal33209_1826 RSal33209_1827
KRH: 
KRH_22060
MLU: 
Mlut_20120
IVA: 
Isova_1931
CFI: 
Celf_2070
BSD: 
BLASA_3125
MMAR: 
MODMU_2979
RXY: 
Rxyl_0473
 » show all
Taxonomy
Reference
1  [PMID:14478080]
  Authors
NAKAGAWA H, TAKEDA Y.
  Title
Phenol hydroxylase.
  Journal
Biochim. Biophys. Acta. 62 (1962) 423-6.
  Organism
Brevibacterium fuscum
Reference
2  [PMID:4146224]
  Authors
Neujahr HY, Gaal A.
  Title
Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum.
  Journal
Eur. J. Biochem. 35 (1973) 386-400.
  Organism
Trichosporon cutaneum
Reference
3  [PMID:810352]
  Authors
Neujahr HY, Gaal A.
  Title
Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
  Journal
Eur. J. Biochem. 58 (1975) 351-7.
  Organism
Trichosporon cutaneum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-84-1
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