KEGG   ENZYME: 1.14.15.11Help
Entry
EC 1.14.15.11               Enzyme                                 

Name
pentalenic acid synthase;
CYP105D7;
sav7469 (gene name);
1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Reaction(IUBMB)
1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O [RN:R10158]
Reaction(KEGG)
Substrate
1-deoxypentalenate [CPD:C20404];
reduced ferredoxin [CPD:C00138];
O2 [CPD:C00007]
Product
pentalenate [CPD:C20405];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.
History
EC 1.14.15.11 created 2012
Orthology
K17876  
pentalenic acid synthase
Genes
NBR: 
SCO: 
SCO0774(3SCF60.06c)
SMA: 
SAV_7469(cyp28)
SGR: 
SSX: 
SCT: 
SCAT_0296(CYP105D)
SCY: 
SHY: 
SHO: 
SALS: 
SFI: 
SCI: 
SALU: 
SALL: 
SLV: 
SLIV_34060(cyp105D1)
SVT: 
STRE: 
SLD: 
STRM: 
FRE: 
VMA: 
 » show all
Taxonomy
Reference
1  [PMID:21081950]
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J. Antibiot. (Tokyo). 64 (2011) 65-71.
  Sequence
[sma:SAV_7469]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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