KEGG   ENZYME: 1.14.19.8Help
Entry
EC 1.14.19.8                Enzyme                                 

Name
pentalenolactone synthase;
penM (gene name);
pntM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone forming)
Reaction(IUBMB)
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O [RN:R10162]
Reaction(KEGG)
Substrate
pentalenolactone F [CPD:C20397];
O2 [CPD:C00007];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Product
pentalenolactone [CPD:C20407];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.
History
EC 1.14.19.8 created 2012 as EC 1.3.7.10, transferred 2013 to EC 1.14.19.8
Pathway
ec01130  Biosynthesis of antibiotics
Orthology
K17476  pentalenolactone synthase
Genes
MYE: AB431_12280
MYN: MyAD_23555
MNE: D174_24015
MAB: MAB_3961c
MMV: MYCMA_2203
MABB: MASS_3974
MAY: LA62_20125
MABO: NF82_19855
MAZ: LA61_20025
MAK: LH56_04370
MCHE: BB28_20400
MSTE: MSTE_04134
SBH: SBI_09672(cyp47)
SLE: sle_13230(sle_13230)
SMAL: SMALA_5792
SRO: Sros_7474
PDX: Psed_5904
PSEH: XF36_16955
SESP: BN6_50330
KAL: KALB_1434
ACTI: UA75_23485
ACAD: UA74_22975
AHG: AHOG_14910(penM1) AHOG_20895(penM2)
TBI: Tbis_2746
 » show all
Taxonomy
Reference
1  [PMID:21284395]
  Authors
Zhu D, Seo MJ, Ikeda H, Cane DE
  Title
Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.
  Journal
J. Am. Chem. Soc. 133 (2011) 2128-31.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.8
IUBMB Enzyme Nomenclature: 1.14.19.8
ExPASy - ENZYME nomenclature database: 1.14.19.8
BRENDA, the Enzyme Database: 1.14.19.8

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