KEGG   ENZYME: 1.14.19.8Help
Entry
EC 1.14.19.8                Enzyme                                 

Name
pentalenolactone synthase;
penM (gene name);
pntM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone forming)
Reaction(IUBMB)
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O [RN:R10162]
Reaction(KEGG)
Substrate
pentalenolactone F [CPD:C20397];
O2 [CPD:C00007];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Product
pentalenolactone [CPD:C20407];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.
History
EC 1.14.19.8 created 2012 as EC 1.3.7.10, transferred 2013 to EC 1.14.19.8
Pathway
Biosynthesis of antibiotics
Orthology
K17476  
pentalenolactone synthase
Genes
SMK: 
SMQ: 
SMX: 
SM11_pC0151(cypX-1)
SMEG: 
REL: 
BIC: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MNE: 
MYE: 
NNO: 
SCT: 
SCY: 
SBH: 
SBI_09672(cyp47)
SRC: 
SCW: 
SLE: 
sle_13230(sle_13230)
SRO: 
AMD: 
AMN: 
AMM: 
AMZ: 
PDX: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
PHH: 
SESP: 
KAL: 
LED: 
AHM: 
SNA: 
TBI: 
 » show all
Taxonomy
Reference
1  [PMID:21284395]
  Authors
Zhu D, Seo MJ, Ikeda H, Cane DE
  Title
Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.
  Journal
J. Am. Chem. Soc. 133 (2011) 2128-31.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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