KEGG ENZYME: 1.14.19.9

ENZYME: 1.14.19.9

Entry

EC 1.14.19.9                Enzyme

Name

tryptophan 7-halogenase;
prnA (gene name);
rebH (gene name);
ktzQ (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

L-tryptophan:FADH2 oxidoreductase (7-halogenating)

Reaction(IUBMB)

L-tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-L-tryptophan + FAD + 2 H2O [RN:R09570]

Reaction(KEGG)

R09570

Substrate

L-tryptophan [CPD:C00078];
FADH2 [CPD:C01352];
chloride [CPD:C00698];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

7-chloro-L-tryptophan [CPD:C19687];
FAD [CPD:C00016];
H2O [CPD:C00001]

Comment

A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase.

History

EC 1.14.19.9 created 2009 as EC 1.14.14.7, transferred 2014 to EC 1.14.19.9, modified 2018

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K14266

tryptophan 7-halogenase

Genes

IZH:	FEM41_13305

TOE:	QMG90_04905

SRR:	SerAS9_4268

SRL:	SOD_c40000

SRY:	M621_21745

SPLY:

Q5A_021600(prnA)

SRS:	SerAS12_4269

SRA:	SerAS13_4269

SMAF:

D781_2597

SRZ:	AXX16_2520

SERM:

CLM71_13470

SRHZ:

FO014_20195

SFO:	Z042_23765

LPV:	HYN51_07845

PRAG:

EKN56_16625

GKN:	PVT67_02605 PVT67_04845

XCC:	XCC2825(prnA) XCC3966(prnA) XCC4133(prnA)

XCB:	XC_1287 XC_4056 XC_4225

XCA:	xcc-b100_1333 xcc-b100_4156 xcc-b100_4345

XCP:	XCR_0306 XCR_3200 XCR_4464

XCV:	XCV3144 XCV4141 XCV4377

XAX:	XACM_2929 XACM_3918 XACM_4146

XAC:	XAC2995(prnA) XAC4051(prnA) XAC4275(prnA)

XCI:	XCAW_00251(prnA) XCAW_00399(prnA) XCAW_03274(prnA)

XCT:	J151_03180 J151_04227 J151_04455

XCJ:	J158_03159 J158_04180 J158_04406

XCU:	J159_03155 J159_04176 J159_04404

XCN:	J169_03178 J169_04224 J169_04452

XCW:	J162_03159 J162_04181 J162_04410

XCR:	J163_03155 J163_04176 J163_04405

XCM:	J164_03155 J164_04177 J164_04405

XCF:	J172_03171 J172_04217 J172_04445

XFU:	XFF4834R_chr16360 XFF4834R_chr39170 XFF4834R_chr41410

XAO:	XAC29_15230 XAC29_20405

XOM:	XOO0227(XOO0227) XOO0354(XOO0354) XOO1160(XOO1160)

XOO:	XOO0248(prnA) XOO0391(prnA) XOO1263(prnA)

XOP:	PXO_02202 PXO_02802 PXO_03613

XOY:	AZ54_01210 AZ54_18175 AZ54_23170

XOR:	XOC_1412 XOC_4642

XOZ:	BE73_00300 BE73_16315

XAL:	XALC_0046 XALC_3150

XSA:	SB85_11965 SB85_15250

XTN:	FD63_00455 FD63_19310

XVE:	BJD12_05865 BJD12_10970 BJD12_11995

XPE:	BJD13_01635 BJD13_17590 BJD13_18805

XHR:	XJ27_05710 XJ27_14105 XJ27_14990

XGA:	BI317_01410 BI317_02405 BI317_11020

XPH:	XppCFBP6546_12895(XppCFBP6546P_12895) XppCFBP6546_14225(XppCFBP6546P_14225) XppCFBP6546_20780(XppCFBP6546P_20780)

XVA:	C7V42_15320 C7V42_20700 C7V42_21795

XAN:	AC801_15025 AC801_20100 AC801_21310

XAR:	XB05_09710 XB05_15350 XB05_16190

XHY:	FZ025_10295

XCZ:	EBN15_18865

XTH:	G4Q83_16585

XEU:	XSP_002911 XSP_003822 XSP_004005

XHD:	LMG31886_13630(rebH_1) LMG31886_41690(rebH_2) LMG31886_43690(prnA)

XPR:	MUG10_10905 MUG10_11865 MUG10_16890

XAG:	HEP73_00118 HEP73_02943 HEP73_04338

XDY:	NYR95_07890 NYR95_21300 NYR95_22465

XAS:	HEP74_00109 HEP74_02774 HEP74_04204

SMZ:

SMD_2241

STEK:

AXG53_00515

SRH:	BAY15_2027

SINC:

DAIF1_21520(rebH)

SPAQ:

STNY_R22560

STEQ:

ICJ04_09370

SGEN:

RKE57_10990

PSU:	Psesu_0608

PSUW:

WQ53_09240 WQ53_11385

PSD:

DSC_13765

PMEX:

H4W19_15360

PJP:	LAG73_06040 LAG73_07150 LAG73_15465 LAG73_15855

PDD:	MNQ95_07720 MNQ95_09975

PWI:	MWN52_14915 MWN52_15025 MWN52_18740 MWN52_18755

LCP:	LC55x_4850

LGU:	LG3211_3661

LMB:	C9I47_2713

LYJ:	FKV23_02880 FKV23_16040

LSOL:

GOY17_08915 GOY17_15330

LARE:

HIV01_005275 HIV01_011120 HIV01_011135

LAUX:

LA521A_30220

LUM:	CNR27_04160 CNR27_08975

TCN:	H9L16_04410 H9L16_04425

XBC:	ELE36_04695

FSG:	LQ771_06495

FED:	LQ772_11560 LQ772_13315

RHD:	R2APBS1_3097

RGL:	CS053_01015 CS053_01640 CS053_15710

RTH:	LRK53_02435 LRK53_15490

DJI:	CH75_07495

DJA:	HY57_04760

DTX:	ATSB10_00600 ATSB10_27850 ATSB10_28850 ATSB10_34900 ATSB10_36600

DTL:	H8F01_11540

DTA:	DYST_03403

LRZ:	BJI69_18130

LPY:	FIV34_10005 FIV34_20610

LFL:	IM816_00240 IM816_09085

LAEG:

L2Y94_10970

LAEO:

L2Y97_10930 L2Y97_22035

LAES:

L2Y96_10605

XBA:	C7S18_13195 C7S18_17415

RBD:	ALSL_0860 ALSL_2664

PNT:	G5B91_04945

PFL:	PFL_3604(prnA)

PPRC:

PFLCHA0_c36450

PPRO:

PPC_3743(prnA)

PCH:	EY04_18035

PCZ:	PCL1606_28070

PCP:	JM49_15070

PSEM:

TO66_16635

PYM:	AK972_1426

PPII:

QL104_19145

PAGR:

E2H98_01780 E2H98_18470 E2H98_18485

ACV:	AMD27_06210

AGYL:

FPL18_02820

ACOI:

NQU59_18025

SON:

SO_3513

SDN:	Sden_2030 Sden_2707

SFR:	Sfri_1309 Sfri_1312 Sfri_1786

SAZ:

Sama_0939

SBL:	Sbal_1078 Sbal_1121 Sbal_1124 Sbal_1409

SBM:	Shew185_1138 Shew185_1176 Shew185_1179 Shew185_1400 Shew185_2037

SBN:	Sbal195_1172 Sbal195_1209 Sbal195_1212 Sbal195_1436 Sbal195_2084

SBP:	Sbal223_2301 Sbal223_2945 Sbal223_3178 Sbal223_3181 Sbal223_3217

SBT:	Sbal678_1200 Sbal678_1239 Sbal678_1242 Sbal678_1471 Sbal678_2086

SBS:	Sbal117_1180 Sbal117_1222 Sbal117_1225 Sbal117_1517

SBB:	Sbal175_2927 Sbal175_3149 Sbal175_3152 Sbal175_3194

SLO:	Shew_1113 Shew_2293

SSE:

Ssed_1209

SPL:

Spea_1098

SHE:	Shewmr4_2941

SHM:	Shewmr7_3023

SHN:	Shewana3_3120

SHL:

Shal_1146

SWD:	Swoo_1140 Swoo_1143 Swoo_1306 Swoo_2208 Swoo_3837 Swoo_3936 Swoo_3937 Swoo_3938

SWP:	swp_1626 swp_1630

SVO:	SVI_1019 SVI_1518 SVI_1519

SHF:	CEQ32_21595

SJA:	SJ2017_1288 SJ2017_1447 SJ2017_1450 SJ2017_2015 SJ2017_2018 SJ2017_2082 SJ2017_2217

SPSW:

Sps_02370

SBJ:	CF168_05240 CF168_09255

SMAV:

CFF01_13830

SHEW:

CKQ84_00720 CKQ84_02085

SLJ:	EGC82_00935 EGC82_11095 EGC82_11105 EGC82_12745 EGC82_14765 EGC82_14780

SMAI:

EXU30_00970 EXU30_15720 EXU30_17345 EXU30_17360

SPOL:

FH971_08810 FH971_13105 FH971_13120

SKH:	STH12_00467(rebH_1) STH12_01336(rebH_2) STH12_03665(rebH_3)

SAES:

HBH39_09575 HBH39_10720 HBH39_10735 HBH39_12430

SLIT:

JQC75_04470

SPSH:

FM037_21320

SEUR:

FM038_006245 FM038_015320 FM038_015325

SCYP:

JYB88_04275 JYB88_09370

SSEM:

JYB85_04475 JYB85_09585

SGLA:

FJ709_05095 FJ709_07645 FJ709_10710

SINV:

K8B83_01875 K8B83_09710 K8B83_09725 K8B83_14180

SXM:	MKD32_05290

SVM:	KDH10_000762 KDH10_001560 KDH10_001563

SACH:

K0H61_09835 K0H61_13180

SAEG:

K0H80_05545 K0H80_11695

SDEO:

D0436_12405 D0436_16960

SMES:

K0I73_12165 K0I73_12180 K0I73_13685

SHAO:

K0H81_08215 K0H81_14540

SZH:	K0H63_05100

SSPA:

K0I31_05615 K0I31_11965

SHNS:

K0J45_05565 K0J45_11700

SRHS:

K0I63_05635 K0I63_11885

SPSJ:

K0I62_14475

SMAY:

K0H60_15620

SOG:	RA178_15360 RA178_16605

SPSR:

EGC80_19790 EGC80_19805

IDT:	C5610_03930

CPS:	CPS_0239 CPS_0992 CPS_1022 CPS_1023 CPS_3699 CPS_3700 CPS_3734

COM:	CMT41_03740 CMT41_03905 CMT41_12850 CMT41_12890 CMT41_12895

COZ:	A3Q34_13470 A3Q34_13475

COLW:

A3Q33_00830 A3Q33_15610 A3Q33_17475 A3Q33_17485 A3Q33_17490 A3Q33_17495 A3Q33_17620 A3Q33_17635 A3Q33_17760 A3Q33_17865 A3Q33_18010

COLA:

DBO93_11560

COV:	EKO29_00275 EKO29_00280 EKO29_08280

CBER:

B5D82_14365 B5D82_15910 B5D82_17130 B5D82_17135

LSD:	EMK97_04355 EMK97_07160

THT:	E2K93_02195 E2K93_02210 E2K93_07980 E2K93_13980

THAP:

FNC98_03305 FNC98_03320 FNC98_11360 FNC98_12860 FNC98_15960 FNC98_16240

THAB:

LP316_02775 LP316_05615 LP316_09335 LP316_09350

THAT:

H3N35_18365 H3N35_18635 H3N35_18665 H3N35_21480

TACT:

SG35_019520 SG35_019820 SG35_019850

TVD:	SG34_009415 SG34_009445

PHA:

PSHAa1353

PTN:	PTRA_a1709(prnA)

PSM:	PSM_A1379 PSM_A1883

PSEO:

OM33_09560 OM33_09825 OM33_16010 OM33_20355 OM33_20360

PIA:	PI2015_1338 PI2015_1821

PPHE:

PP2015_1295 PP2015_3630

PBW:	D172_001325 D172_007460 D172_009385 D172_009845 D172_010375 D172_010380

PRR:	AT705_04675

PLZ:	S4054249_07065 S4054249_08730

PALN:

B0W48_16180

PPIS:

B1L02_10070

PEA:	PESP_a0243 PESP_a1356 PESP_a1684(prnA) PESP_a2173(prnA) PESP_a2210(prnA) PESP_a2308 PESP_a2309(prnA)

PSPO:

PSPO_a1380(prnA) PSPO_a1442(prnA) PSPO_b0274 PSPO_b1267 PSPO_b1268

PART:

PARC_a0212 PARC_a1605(prnA) PARC_a1606 PARC_a2186 PARC_a2299(prnA)

PTU:	PTUN_a1620(prnA) PTUN_a1621(prnA) PTUN_a1624 PTUN_a1625 PTUN_a1728(prnA) PTUN_a1858(prnA)

PNG:	PNIG_a1798(prnA) PNIG_p0040

PTD:	PTET_a1596(prnA) PTET_a2158(prnA)

PSEN:

PNC201_06690(rebH1)

PDJ:	D0907_05960 D0907_07245 D0907_09035 D0907_09040 D0907_12865

PAGA:

PAGA_a0247 PAGA_a1717 PAGA_a2201(prnA)

PCAR:

PC2016_1297 PC2016_1298 PC2016_1401 PC2016_2965

PMAA:

CPA52_01115 CPA52_05300 CPA52_06760 CPA52_06765 CPA52_07285 CPA52_09220

PXI:	J5O05_00970 J5O05_00985 J5O05_16795 J5O05_16865 J5O05_16875 J5O05_16880

PVB:	J5X90_16530

PSAZ:

PA25_11710 PA25_11720 PA25_12430 PA25_16680

PDV:	FFU37_05885 FFU37_07935 FFU37_08345 FFU37_08350 FFU37_16425

PFLI:

CTT31_06790

PSHO:

KQ246_00770 KQ246_20160

PMAZ:

R5H13_07345

PSYM:

J1N51_08225 J1N51_13150

AMC:	MADE_1009520 MADE_1019530

AMH:	I633_10290 I633_20160 I633_20735 I633_21345 I633_21350

AMAA:

amad1_10325 amad1_19215 amad1_19710

AMAL:

I607_09170 I607_18205

AMAE:

I876_09530 I876_18580

AMAO:

I634_09610 I634_18345

AMAD:

I636_09925 I636_18360 I636_18845

AMAI:

I635_10320 I635_19205 I635_19700

AMAG:

I533_09490 I533_18275

AMAC:

MASE_02600 MASE_09130 MASE_18615 MASE_19100 MASE_19660 MASE_19665

AMB:	AMBAS45_02875 AMBAS45_09685 AMBAS45_18850

AMG:	AMEC673_02795 AMEC673_09460 AMEC673_18590 AMEC673_19415 AMEC673_19420

AMK:	AMBLS11_08935 AMBLS11_17850 AMBLS11_18405 AMBLS11_18850 AMBLS11_18855

ALT:	ambt_07620 ambt_17280 ambt_22070 ambt_22075

AAL:	EP13_01165 EP13_09590 EP13_19055

AAUS:

EP12_01215 EP12_16110 EP12_16115 EP12_16150

ASP:	AOR13_1413 AOR13_2668 AOR13_3252 AOR13_3556 AOR13_3557

ASQ:	AVL57_02520 AVL57_05400 AVL57_11580 AVL57_20795 AVL57_20800

AAW:	AVL56_01270 AVL56_04175 AVL56_10730 AVL56_19725 AVL56_19730

ALR:	DS731_05125 DS731_05130 DS731_10490 DS731_16505 DS731_16510 DS731_16555 DS731_20230 DS731_20235

ALE:	AV939_01335 AV939_04470 AV939_10600 AV939_19785 AV939_19790

ALZ:	AV940_01335 AV940_04315 AV940_10370 AV940_19480 AV940_19485

APEL:

CA267_006540 CA267_007625 CA267_007635 CA267_007650 CA267_011290 CA267_018090

SALM:

D0Y50_03705 D0Y50_11830 D0Y50_11920 D0Y50_15220 D0Y50_17935 D0Y50_18235 D0Y50_18250

SALK:

FBQ74_00400 FBQ74_01065 FBQ74_01080 FBQ74_03905

SMAA:

IT774_00685 IT774_03000

GAG:	Glaag_1076 Glaag_1077 Glaag_1905 Glaag_2305 Glaag_2348 Glaag_3525 Glaag_3676 Glaag_3730 Glaag_4254

GNI:	GNIT_3223 GNIT_3226

GPS:	C427_0190 C427_0191 C427_0898 C427_2235 C427_3387 C427_3390

PMES:

FX988_00215 FX988_00606 FX988_02648 FX988_03093 FX988_03229 FX988_03654 FX988_03655

PAT:	Patl_0807 Patl_1964 Patl_2546 Patl_3276 Patl_3277 Patl_3685 Patl_3817 Patl_4289

LAL:	AT746_03955 AT746_09735 AT746_17110 AT746_17125 AT746_17575 AT746_17600 AT746_17605 AT746_17610

CATE:

C2869_04745 C2869_05055 C2869_16750

SALH:

HMF8227_00170(prnA) HMF8227_00244 HMF8227_00568 HMF8227_00895 HMF8227_00898 HMF8227_01495 HMF8227_02385

PAEW:

KIH87_08450 KIH87_09625 KIH87_13405 KIH87_13420

CATT:

OLW01_01665 OLW01_14415 OLW01_14635 OLW01_16375 OLW01_16640 OLW01_17270 OLW01_17665 OLW01_18405

ALII:

QR722_00455 QR722_03555 QR722_06615

PMAW:

MACH26_02900 MACH26_02910 MACH26_05140 MACH26_23690

FBL:	Fbal_1097 Fbal_2925

CJA:	CJA_0218 CJA_0354 CJA_1049(rebH) CJA_1070 CJA_1159 CJA_2713 CJA_2881 CJA_3150 CJA_3467 CJA_3630

CEB:	B0D95_05870 B0D95_07910 B0D95_07915 B0D95_10275 B0D95_10445 B0D95_10690 B0D95_10695 B0D95_10705 B0D95_11360 B0D95_11375 B0D95_11585 B0D95_12915 B0D95_13540 B0D95_16795 B0D95_20010

CELL:

CBR65_07160 CBR65_07165 CBR65_07525 CBR65_07545 CBR65_10230 CBR65_11890 CBR65_11905 CBR65_12890 CBR65_12905 CBR65_16025 CBR65_16125 CBR65_16130 CBR65_16530 CBR65_16705 CBR65_16710 CBR65_16715 CBR65_16730 CBR65_16735 CBR65_16740 CBR65_17680 CBR65_17790 CBR65_18440 CBR65_19585 CBR65_19605

CEK:	D0B88_00155 D0B88_00160 D0B88_02145 D0B88_02150 D0B88_02155 D0B88_04320 D0B88_04890 D0B88_05355 D0B88_05690 D0B88_06805 D0B88_07010 D0B88_07015 D0B88_07020 D0B88_07935 D0B88_11510 D0B88_11755 D0B88_13300 D0B88_13305 D0B88_14240 D0B88_16250 D0B88_16255 D0B88_17740 D0B88_18630 D0B88_18655

CEG:	D0C16_02295 D0C16_02500 D0C16_07190 D0C16_07425 D0C16_10855 D0C16_11325 D0C16_13105 D0C16_14095 D0C16_14100 D0C16_14150 D0C16_14205 D0C16_15215 D0C16_15225 D0C16_16010 D0C16_16015 D0C16_16020 D0C16_18210 D0C16_18930 D0C16_20375 D0C16_20550 D0C16_20555 D0C16_20560 D0C16_20810 D0C16_20815

SDE:	Sde_1094 Sde_1096 Sde_1104 Sde_1105 Sde_1262 Sde_1398 Sde_1401 Sde_2391 Sde_2498 Sde_2807 Sde_2828 Sde_3053

TTU:	TERTU_0510 TERTU_1076 TERTU_1501 TERTU_2325 TERTU_2326

SAGA:

M5M_04370 M5M_05400 M5M_05405 M5M_05410 M5M_10725 M5M_17000 M5M_18325 M5M_18335

MARQ:

MARGE09_P0515 MARGE09_P0516 MARGE09_P0517 MARGE09_P1182 MARGE09_P1184 MARGE09_P4106

GIL:	NHM04_00450 NHM04_00455 NHM04_00475 NHM04_02155 NHM04_02160 NHM04_06595 NHM04_09235 NHM04_09470 NHM04_09475 NHM04_09480 NHM04_09490 NHM04_09495 NHM04_09500 NHM04_10390 NHM04_12600 NHM04_12790 NHM04_15560 NHM04_15565

MKE:	OOT55_00010 OOT55_01235 OOT55_06700 OOT55_09170 OOT55_09180 OOT55_12030 OOT55_12035 OOT55_12465 OOT55_13175 OOT55_13220 OOT55_13845 OOT55_13850 OOT55_17735 OOT55_17740 OOT55_17755

MTHD:

A3224_00665 A3224_10280 A3224_13185 A3224_13675 A3224_13775 A3224_13780

MICC:

AUP74_00047(rebH_2) AUP74_00418(rebH_3) AUP74_01694(rebH_5) AUP74_01714(rebH_6) AUP74_01717(rebH_7)

MAGA:

Mag101_04505 Mag101_05020 Mag101_05025 Mag101_05030 Mag101_05845 Mag101_06145 Mag101_15200 Mag101_15440 Mag101_15470 Mag101_15480

MHYD:

GTQ55_04930 GTQ55_15220 GTQ55_15255 GTQ55_15580 GTQ55_15640 GTQ55_17060

MCEL:

LPW13_00265 LPW13_00270 LPW13_08270 LPW13_12545 LPW13_12580 LPW13_12725 LPW13_12730 LPW13_13080

MICZ:

GL2_26880 GL2_26890

MPAF:

R5R33_07020 R5R33_07055 R5R33_07065 R5R33_14210

MBRG:

PVT68_08660 PVT68_08695 PVT68_08790 PVT68_08830 PVT68_08835 PVT68_09115

HJA:	BST95_08010

HALC:

EY643_17645 EY643_17650 EY643_17655

AFUS:

EYZ66_09500

PAQM:

E0F26_10050 E0F26_10065

RHEI:

ATY27_01525 ATY27_01540 ATY27_02830 ATY27_05305 ATY27_06450 ATY27_06455 ATY27_06460 ATY27_07595 ATY27_11645 ATY27_18400 ATY27_18405 ATY27_18410

WEZ:	IC757_02330

OME:	OLMES_3770

PLEI:

Q9312_15630 Q9312_15640

KKO:	Kkor_1103 Kkor_1104

BPM:	BURPS1710b_A1115(prnA)

BPL:	BURPS1106A_A2733

BPD:	BURPS668_A2885

BPSE:

BDL_5422(prnA)

BPSM:

BBQ_4121(prnA)

BPSU:

BBN_5475(prnA)

BPSD:

BBX_4589(prnA)

BPQ:	BPC006_II2696

BPK:	BBK_4751(prnA)

BPSH:

DR55_5722(prnA)

BPSA:

BBU_3999(prnA)

BPSO:

X996_5526(prnA)

BUT:	X994_5084(prnA)

BTZ:	BTL_5470(prnA)

BTHA:

DR62_5270

BOK:	DM82_6302(prnA)

BUU:	WS70_23855

BSAV:

WS86_22620

BUR:	Bcep18194_C6706

BCM:	Bcenmc03_6983

BAM:

Bamb_4726

BAC:	BamMC406_5264

BCEP:

APZ15_34520

BPYR:

ABD05_31840

BCON:

NL30_32800

BUB:	BW23_5778(prnA)

BSEM:

WJ12_18250

BMEC:

WJ16_17180

BARI:

NLX30_39220

BURK:

DM992_38835

RFR:

Rfer_1114

RHOA:

HZ993_16770 HZ993_23570

LIM:	L103DPR2_00071(prnA)

DIH:	G7047_26285

RDP:	RD2015_4477

ROI:	N4261_13120 N4261_24525

PKT:	AT984_06420 AT984_21730

PAQA:

K9V56_003700 K9V56_012105 K9V56_015905 K9V56_019865

MIU:	ABE85_11130 ABE85_25300

LCH:

Lcho_3228

MASW:

AM586_04165 AM586_15695 AM586_15710 AM586_23370

MASS:

CR152_07710 CR152_20130

MTIM:

DIR46_12900 DIR46_18415 DIR46_23025

MASY:

DPH57_20335 DPH57_20350 DPH57_25790

MANC:

IV454_13655 IV454_27775

MFY:	HH212_12705 HH212_20435 HH212_20960

MVAR:

MasN3_04320(prnA) MasN3_29310 MasN3_42980

MENY:

LSQ66_00155 LSQ66_00170 LSQ66_12075 LSQ66_12085 LSQ66_22590

MASZ:

C9I28_01550 C9I28_01565 C9I28_23500

MALI:

EYF70_05430 EYF70_10385 EYF70_29085 EYF70_29100

MUM:	FCL38_13190 FCL38_20515 FCL38_20530

MFLA:

GO485_10250 GO485_15755 GO485_15770 GO485_26950

MPLI:

E1742_10580 E1742_16270 E1742_16285

TCT:	PX653_21720 PX653_21735 PX653_27405

DUG:	HH213_05265 HH213_08435 HH213_09760 HH213_14300 HH213_14315 HH213_21195

DZO:	SR858_13735

TMJ:	P0M04_14025 P0M04_14035 P0M04_14465 P0M04_19505 P0M04_19520 P0M04_24325 P0M04_25555 P0M04_25570 P0M04_28270 P0M04_29750 P0M04_32640

EHB:	E7V67_021300 E7V67_026905 E7V67_026920

UPV:	EJN92_04270

UPI:	EJG51_007940

UND:	UNDKW_1057

RHI:	NGR_a00820

SINO:

SS05631_a45620

BAPI:

BBC0122_019690

MEA:	Mex_1p2407

MEX:

Mext_2404

MPO:

Mpop_2363

MZA:	B2G69_19640

META:

Y590_11615

MEE:	DA075_13115

METD:

C0214_13460

METS:

DK389_09215

DSAL:

K1X15_04585

DOY:	JI749_05785

DAG:	PSQ19_09375

THD:	BHV28_12250

CCR:	CC_0787 CC_0971 CC_0972 CC_1002 CC_1529 CC_1755 CC_2288 CC_2805 CC_2807 CC_2808

CCS:	CCNA_00828 CCNA_01022 CCNA_01023 CCNA_01054 CCNA_01598 CCNA_01831 CCNA_02371 CCNA_02896 CCNA_02898 CCNA_02899

CAK:	Caul_0296 Caul_0297 Caul_1290 Caul_1839 Caul_1840 Caul_1841 Caul_1842 Caul_1853 Caul_1866 Caul_2064 Caul_2138 Caul_2143 Caul_2144 Caul_2406 Caul_3278 Caul_3561 Caul_4092

CSE:	Cseg_1566 Cseg_2005 Cseg_2051 Cseg_2053 Cseg_2054 Cseg_3271 Cseg_3732 Cseg_3733

CHQ:	AQ619_03595 AQ619_03800 AQ619_03805 AQ619_03810 AQ619_03815 AQ619_06000 AQ619_11175 AQ619_12815 AQ619_12820 AQ619_13170

CFH:	C1707_01450 C1707_01455 C1707_07875 C1707_10580 C1707_10585 C1707_12315 C1707_15840 C1707_15845 C1707_15850 C1707_24765

CAUF:

CSW63_12155 CSW63_17575 CSW63_18125 CSW63_18135 CSW63_18140 CSW63_18270 CSW63_18275

CAUL:

KCG34_03255 KCG34_05880 KCG34_07995 KCG34_10965 KCG34_25110

PZU:

PHZ_c2922

BSB:	Bresu_2902 Bresu_2932

BRD:	JL11_06740 JL11_06745 JL11_08895

BRG:	A4249_01995 A4249_02000

BRL:	BZG35_05160 BZG35_05185 BZG35_05190 BZG35_05195 BZG35_05515 BZG35_07310 BZG35_16770

BVC:	CEP68_00870 CEP68_00875 CEP68_00885 CEP68_01695

BREV:

E7T10_08940 E7T10_13035 E7T10_13040 E7T10_13050

BMED:

GYM46_04900 GYM46_11970 GYM46_11975 GYM46_12255

BND:	KWG56_10000

BGOE:

IFJ75_05080 IFJ75_05115 IFJ75_05120

BVIT:

JIP62_01295 JIP62_01300 JIP62_12950 JIP62_13905 JIP62_13920 JIP62_13925

BALB:

M8231_01080 M8231_01100 M8231_01105 M8231_03180 M8231_08880 M8231_08885 M8231_11720

BFQ:	JX001_08125 JX001_09090 JX001_09100 JX001_09105 JX001_14020 JX001_14025

BRES:

E4341_07900 E4341_12075 E4341_12080 E4341_12090

BREA:

HZ989_05275 HZ989_09535

AEX:	Astex_0704 Astex_1893 Astex_1894 Astex_1988 Astex_2586 Astex_2721 Astex_3213 Astex_3306 Astex_3307 Astex_3308 Astex_3309 Astex_3326 Astex_3382 Astex_3383 Astex_3384 Astex_3619

ASTI:

Q1W73_00460 Q1W73_01365 Q1W73_03255 Q1W73_05535 Q1W73_07955 Q1W73_07960 Q1W73_10105 Q1W73_13715 Q1W73_14965 Q1W73_14970 Q1W73_14975 Q1W73_15425 Q1W73_16080 Q1W73_16085 Q1W73_16090 Q1W73_16095

APAH:

KB221_07290 KB221_07310 KB221_07315 KB221_11505

MMR:	Mmar10_2721 Mmar10_2722 Mmar10_2723 Mmar10_2724 Mmar10_2733 Mmar10_2734

HYT:	HXX25_10225 HXX25_10230 HXX25_10235 HXX25_10240

HBA:	Hbal_2451 Hbal_2452 Hbal_2454 Hbal_2461 Hbal_2462 Hbal_2796 Hbal_3201

HBC:	AEM38_01235 AEM38_03490

NAR:	Saro_1604 Saro_1607 Saro_1882 Saro_1889

NPP:	PP1Y_AT20776 PP1Y_Mpl911

NPN:	JI59_18265

NRE:	BES08_00125

NOV:	TQ38_023725

NOT:	C7W88_00415 C7W88_00430 C7W88_12285 C7W88_19850

NOR:	FA702_20235

NGF:	FRF71_02040 FRF71_02055 FRF71_03490 FRF71_08605

NDR:	HT578_16875

NHUM:

PQ457_03050 PQ457_09560 PQ457_17400 PQ457_17720 PQ457_20390

SAL:	Sala_0182 Sala_0740 Sala_0915 Sala_0918

SPHK:

SKP52_06765 SKP52_06780 SKP52_12890

SPHP:

LH20_00455

SMAG:

AN936_10600 AN936_10615

SMAZ:

LH19_14975 LH19_14990

STER:

AOA14_04315

SPHQ:

BWQ93_08360 BWQ93_08365 BWQ93_08370 BWQ93_08540 BWQ93_08555 BWQ93_10655 BWQ93_10725 BWQ93_10730 BWQ93_10745 BWQ93_17780 BWQ93_17785 BWQ93_17865 BWQ93_20150

SPHX:

E5675_04520 E5675_06795 E5675_06800 E5675_06805 E5675_08080 E5675_08095 E5675_14160 E5675_14165

SINA:

KNJ79_01910 KNJ79_04095 KNJ79_06985 KNJ79_07000 KNJ79_12160 KNJ79_12185 KNJ79_12190 KNJ79_12200 KNJ79_12205

SPHU:

SPPYR_0415 SPPYR_0958 SPPYR_0959 SPPYR_0960 SPPYR_2280 SPPYR_2283 SPPYR_2572 SPPYR_2884 SPPYR_2885

SPHM:

G432_14595 G432_14600 G432_16620

STAX:

MC45_01225 MC45_01980 MC45_04520 MC45_07120 MC45_07125 MC45_07130 MC45_07135 MC45_09815 MC45_09820 MC45_09825 MC45_12650 MC45_13060 MC45_16000 MC45_16045 MC45_17590

SPHI:

TS85_08030 TS85_10270 TS85_10275 TS85_13100

SSAN:

NX02_07560 NX02_18010

SNJ:	A7E77_04240 A7E77_04310 A7E77_04345 A7E77_15290 A7E77_15295 A7E77_15300 A7E77_15690

SMY:	BJP26_08645 BJP26_08650 BJP26_08655 BJP26_09050 BJP26_13220 BJP26_13290 BJP26_13325 BJP26_18360

SPAN:

AWL63_09435 AWL63_11695

SKR:	BRX40_04120 BRX40_06800 BRX40_06915 BRX40_06925 BRX40_07205 BRX40_16900 BRX40_17105 BRX40_17325

SPLM:

BXU08_04150 BXU08_06855 BXU08_06860 BXU08_06865 BXU08_07125 BXU08_07215 BXU08_07220 BXU08_08470 BXU08_08475 BXU08_08535 BXU08_08540 BXU08_13370 BXU08_16210 BXU08_16590 BXU08_18105 BXU08_18110

SPLK:

AV944_00760 AV944_06965 AV944_06970 AV944_06975 AV944_08315 AV944_09340 AV944_10045 AV944_10225 AV944_11935 AV944_13075 AV944_13305

SPHC:

CVN68_01435 CVN68_02715 CVN68_02720 CVN68_05135 CVN68_09110 CVN68_09115 CVN68_09185 CVN68_09190 CVN68_10685 CVN68_10690 CVN68_20490

SPHF:

DM480_00205 DM480_08710 DM480_08740 DM480_10120 DM480_12765

SPAU:

DRN02_000480 DRN02_000485 DRN02_000490 DRN02_000915 DRN02_002165 DRN02_003950 DRN02_005970 DRN02_006165 DRN02_015540

SRHI:

H9L12_00215 H9L12_00355 H9L12_00360 H9L12_00370 H9L12_00390 H9L12_01575 H9L12_09410 H9L12_10305

SLAN:

GV829_02725 GV829_09180 GV829_10825

SDH:	H9L15_02145 H9L15_07555 H9L15_12345

SSED:

H9L14_09665

SPAP:

H3Z74_00945 H3Z74_00950 H3Z74_08095 H3Z74_12390 H3Z74_17475 H3Z74_18680 H3Z74_18695

SPAI:

FPZ24_00095 FPZ24_10555 FPZ24_12845 FPZ24_12850 FPZ24_15795 FPZ24_15810

SPII:

G7077_01300 G7077_03100 G7077_03105 G7077_03110 G7077_03115 G7077_03795 G7077_03800 G7077_04360 G7077_05460

SSAU:

H8M03_06400 H8M03_06415 H8M03_07265 H8M03_07270 H8M03_07275 H8M03_07280 H8M03_07415 H8M03_07500

SCHY:

GVO57_07985

SSUA:

FPZ54_00195 FPZ54_02585 FPZ54_02590 FPZ54_11705 FPZ54_11720 FPZ54_11795 FPZ54_11985 FPZ54_15595 FPZ54_17065 FPZ54_17070 FPZ54_17075 FPZ54_18510 FPZ54_18525

SBIN:

SBA_ch2_8040

SAER:

NEF64_04525 NEF64_04530 NEF64_04540 NEF64_05400 NEF64_05405 NEF64_08130 NEF64_09275 NEF64_09285 NEF64_09290 NEF64_10945 NEF64_11050

SMOR:

LHA26_14170 LHA26_18535 LHA26_18680

SGLC:

M1K48_06720

SQO:	NMP03_05510 NMP03_05520 NMP03_08260 NMP03_15120 NMP03_15125 NMP03_15165

SCAB:

LZK98_06835 LZK98_10320 LZK98_10385 LZK98_16965 LZK98_20200

SRAD:

LLW23_11905

SHAN:

PPZ50_09800 PPZ50_11140 PPZ50_11180 PPZ50_12880 PPZ50_13135 PPZ50_13140 PPZ50_13150 PPZ50_14215 PPZ50_16250 PPZ50_16260

SNOS:

K8P63_03235 K8P63_06660 K8P63_07260 K8P63_12085 K8P63_13355 K8P63_18685

SDON:

M9980_02890

SSAG:

KV697_00190 KV697_00195 KV697_00200 KV697_03175 KV697_04525 KV697_14305 KV697_18135 KV697_18140 KV697_18145 KV697_18535 KV697_19645

SABI:

PBT88_10790 PBT88_10800 PBT88_13535 PBT88_13895 PBT88_15370

SJP:	SJA_C2-02280

SYB:	TZ53_09660 TZ53_09885

SPHR:

BSY17_3555 BSY17_3569

SYA:	A6768_12820 A6768_22480

SBAR:

H5V43_19780 H5V43_20005

SAMI:

SAMIE_1002480 SAMIE_1002490 SAMIE_1002500 SAMIE_1033990

SPPH:

KFK14_01990

CIJ:	WG74_05320

SFLA:

SPHFLASMR4Y_00642(rebH) SPHFLASMR4Y_00643(rebH)

SPHY:

CHN51_09120

SPHL:

LPB140_02500 LPB140_04555 LPB140_05345 LPB140_05350 LPB140_05360 LPB140_05365

SLAA:

EUU25_06535 EUU25_09810 EUU25_12880 EUU25_16350 EUU25_16355 EUU25_16360 EUU25_16365

BMAA:

T8S45_09185

SPZR:

G5C33_10730 G5C33_10735

HGN:	E6W36_05135

PALG:

HFP57_01285 HFP57_01290

PARP:

HFP51_02685 HFP51_02690

PARJ:

J4G78_13615

ACOB:

P0Y56_09890

SPHS:

ETR14_01045 ETR14_01060 ETR14_01435 ETR14_01440 ETR14_06770 ETR14_08050 ETR14_08605 ETR14_09110 ETR14_09525 ETR14_13845 ETR14_16025 ETR14_16030 ETR14_16035 ETR14_16040 ETR14_17390 ETR14_25205

SFLV:

IC614_06220 IC614_08355 IC614_08370

SAND:

H3309_12395 H3309_12510

POQ:	KZX46_07815 KZX46_22120

PMEA:

KTC28_03345

AEP:	AMC99_02455 AMC99_02458

ALH:	G6N82_04490 G6N82_04505 G6N82_08275

ARUE:

QQX03_01410

AAY:	WYH_02200(rebH)

PMAS:

NCF86_01535 NCF86_14410

ANH:	A6F65_00847(rebH_2) A6F65_02486(prnA)

ADO:	A6F68_02840(rebH) A6F68_02902(prnA)

CNA:	AB433_11070 AB433_11085

CMAN:

A9D14_05580 A9D14_07220 A9D14_07225 A9D14_07235 A9D14_07240 A9D14_07250 A9D14_16930 A9D14_18570

EGN:	BMF35_a0032 BMF35_a1032

EFV:	CHH26_02865 CHH26_09190 CHH26_09195 CHH26_09355

QCI:	NCF85_08025 NCF85_08030 NCF85_10530 NCF85_10545 NCF85_15875

QSO:	IRL76_09065 IRL76_09525

QAR:	K3148_01545 K3148_08045 K3148_08655

QGE:	K3136_05325 K3136_12320

QPS:	K3166_08945 K3166_09670 K3166_09685

ELI:

ELI_03165

ERK:	CD351_14245 CD351_14260 CD351_14295

ERF:	FIU90_07215(prnA1) FIU90_07230(rebH1) FIU90_14280(rebH2) FIU90_14285(rebH3) FIU90_14290(rebH4) FIU90_14295(rebH5) FIU90_15030(prnA2)

EMV:	HQR01_14295 HQR01_14505 HQR01_14520

PNS:	A9D12_00165 A9D12_01475 A9D12_01490

PORL:

BG023_112350 BG023_112708 BG023_112711

PHZ:	CHX26_12975 CHX26_14675 CHX26_14690

POT:	E2E27_07150 E2E27_07165 E2E27_07685 E2E27_07690 E2E27_07700 E2E27_07705 E2E27_08165 E2E27_09180

AFLV:

QQW98_02040 QQW98_11400

NAO:	Y958_17360 Y958_17370 Y958_19595 Y958_21300 Y958_24910 Y958_27480 Y958_30430 Y958_30445

NCB:	C0V82_07105 C0V82_15910 C0V82_15915 C0V82_18905 C0V82_18910 C0V82_19485 C0V82_19490 C0V82_21735 C0V82_23630 C0V82_25815 C0V82_25820 C0V82_25825 C0V82_25830 C0V82_26005

ECOG:

FIV45_02305 FIV45_03215 FIV45_03600 FIV45_12000

TMK:	QGN29_01825 QGN29_04215 QGN29_04220 QGN29_04225 QGN29_04230 QGN29_06795 QGN29_14280

GSO:	PH603_00690 PH603_01310 PH603_02810 PH603_06040 PH603_13095 PH603_13100 PH603_16220

MBD:	MEBOL_008074

MRM:	A7982_07450

BBA:	Bd1390(prnA)

BBAT:

Bdt_1370(prnA)

BBAC:

EP01_16870

BDZ:	DOM22_11990

BDK:	HW988_11105

SRW:	TUE45_04027(rebH_2)

SPEU:

CGZ69_27150

PSEQ:

AD006_32415

KBU:	Q4V64_36770

UME:	RM788_41030

CYP:	PCC8801_1365

CYH:	Cyan8802_1395

MPRO:

BJP34_00885

NOP:	Nos7524_0707

NOE:	CLI64_06600 CLI64_06605

CSG:	Cylst_4395 Cylst_4396

LUO:	HHL09_00475 HHL09_03265 HHL09_12810 HHL09_12815 HHL09_13380

FMR:	Fuma_01240(rebH_1) Fuma_01246(rebH_2)

MGIN:

FRZ54_05295

CAMU:

CA2015_3234

SALI:

L593_06180

HRR:	HZS55_06640

HPEL:

HZS54_07190

NAY:	HYG81_13725

» show all

Reference

1 [PMID:15272170]

Authors

Dong C, Kotzsch A, Dorward M, van Pee KH, Naismith JH

Title

Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.

Journal

Acta Crystallogr D Biol Crystallogr 60:1438-40 (2004)
DOI:10.1107/S0907444904012521

Sequence

[ag:AAB97504]

Reference

2 [PMID:15743914]

Authors

Yeh E, Garneau S, Walsh CT

Title

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis.

Journal

Proc Natl Acad Sci U S A 102:3960-5 (2005)
DOI:10.1073/pnas.0500755102

Sequence

[ag:BAC10682]

Reference

3 [PMID:17876823]

Authors

Bitto E, Huang Y, Bingman CA, Singh S, Thorson JS, Phillips GN Jr

Title

The structure of flavin-dependent tryptophan 7-halogenase RebH.

Journal

Proteins 70:289-93 (2008)
DOI:10.1002/prot.21627

Sequence

[ag:BAC10682]

Reference

4 [PMID:18828589]

Authors

Heemstra JR Jr, Walsh CT

Title

Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.

Journal

J Am Chem Soc 130:14024-5 (2008)
DOI:10.1021/ja806467a

Sequence

[ag:ABV56597]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.9

IUBMB Enzyme Nomenclature:

1.14.19.9

ExPASy - ENZYME nomenclature database:

1.14.19.9

BRENDA, the Enzyme Database:

1.14.19.9

DBGET integrated database retrieval system