KEGG   ENZYME: 1.14.21.9Help
Entry
EC 1.14.21.9                Enzyme                                 

Name
mycocyclosin synthase;
CYP121;
rv2276 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
cyclo(L-tyrosyl-L-tyrosyl),NADPH:oxygen oxidoreductase (diarylbridge-forming)
Reaction(IUBMB)
cyclo(L-tyrosyl-L-tyrosyl) + NADPH + H+ + O2 = mycocyclosin + NADP+ + 2 H2O [RN:R10323]
Reaction(KEGG)
Substrate
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
mycocyclosin [CPD:C20517];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.
History
EC 1.14.21.9 created 2013
Orthology
K17483  
mycocyclosin synthase
Genes
MTU: 
Rv2276(cyp121)
MTV: 
MTC: 
MRA: 
MRA_2295(cyp121)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTE: 
MTUR: 
CFBS_2409(cyp121)
MTL: 
MTO: 
MTCTRI2_2311(cyp121)
MTD: 
UDA_2276(cyp121)
MTJ: 
MTUC: 
MTUE: 
MTX: 
MTUT: 
HKBT1_2400(cyp121)
MTUU: 
HKBT2_2402(cyp121)
MTQ: 
HKBS1_2406(cyp121)
MBO: 
Mb2299(cyp121)
MBB: 
BCG_2293(cyp121)
MBT: 
JTY_2287(cyp121)
MBM: 
BCGMEX_2281(cyp121)
MBK: 
MBX: 
MBZ: 
MCE: 
MCAN_23001(cyp121)
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
SVE: 
SVT: 
SLD: 
SRW: 
KPHY: 
 » show all
Taxonomy
Reference
1  [PMID:19416919]
  Authors
Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courcon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M
  Title
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 7426-31.
  Sequence
[mtu:Rv2276]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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