KEGG   ENZYME: 1.14.21.9Help
Entry
EC 1.14.21.9                Enzyme                                 

Name
mycocyclosin synthase;
CYP121;
rv2276 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
cyclo(L-tyrosyl-L-tyrosyl),NADPH:oxygen oxidoreductase (diarylbridge-forming)
Reaction(IUBMB)
cyclo(L-tyrosyl-L-tyrosyl) + NADPH + H+ + O2 = mycocyclosin + NADP+ + 2 H2O [RN:R10323]
Reaction(KEGG)
Substrate
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
mycocyclosin [CPD:C20517];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.
History
EC 1.14.21.9 created 2013
Orthology
K17483  mycocyclosin synthase
Genes
MTU: Rv2276(cyp121)
MTV: RVBD_2276
MTC: MT2336
MRA: MRA_2295(cyp121)
MTF: TBFG_12301
MTB: TBMG_01706
MTK: TBSG_01716
MTZ: TBXG_001689
MTG: MRGA327_14025
MTE: CCDC5079_2109
MTUR: CFBS_2409(cyp121)
MTO: MTCTRI2_2311(cyp121)
MTD: UDA_2276(cyp121)
MTUC: J113_15840
MTUE: J114_12200
MTUT: HKBT1_2400(cyp121)
MTUU: HKBT2_2402(cyp121)
MTQ: HKBS1_2406(cyp121)
MBO: BQ2027_MB2299(cyp121)
MBB: BCG_2293(cyp121)
MBT: JTY_2287(cyp121)
MBM: BCGMEX_2281(cyp121)
MBX: BCGT_2100
MCE: MCAN_23001(cyp121)
MCQ: BN44_50222(cyp)
MCV: BN43_31518(cyp)
MCX: BN42_40197(cyp)
MCZ: BN45_50612(cyp)
MMIC: RN08_2523
SVE: SVEN_1865
SLD: T261_7888
SLAU: SLA_4278
SALJ: SMD11_0297
 » show all
Taxonomy
Reference
1  [PMID:19416919]
  Authors
Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courcon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M
  Title
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 7426-31.
  Sequence
[mtu:Rv2276]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.21.9
IUBMB Enzyme Nomenclature: 1.14.21.9
ExPASy - ENZYME nomenclature database: 1.14.21.9
BRENDA, the Enzyme Database: 1.14.21.9

DBGET integrated database retrieval system