KEGG   ENZYME: 1.14.99.1Help
Entry
EC 1.14.99.1                Enzyme                                 
Name
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
BRITE hierarchy
Sysname
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Reaction(KEGG)
R01599;
(other) R00073 R01590
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Substrate
arachidonate [CPD:C00219];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
prostaglandin H2 [CPD:C00427];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
This enzyme acts both as a dioxygenase and as a peroxidase.
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00509  
prostaglandin-endoperoxide synthase 1
K11987  
prostaglandin-endoperoxide synthase 2
Genes
HSA: 
5742(PTGS1) 5743(PTGS2)
PTR: 
464713(PTGS1) 469616(PTGS2)
PPS: 
100985650(PTGS2) 100993705(PTGS1)
GGO: 
101141060(PTGS1) 101146681(PTGS2)
PON: 
100436566(PTGS2) 100437175(PTGS1)
MCC: 
698213(PTGS1) 716671(PTGS2)
MMU: 
19224(Ptgs1) 19225(Ptgs2)
RNO: 
24693(Ptgs1) 29527(Ptgs2)
CFA: 
403544(PTGS1) 442942(PTGS2)
AML: 
FCA: 
100126581(PTGS2) 101092557(PTGS1)
BTA: 
282022(PTGS1) 282023(PTGS2)
SSC: 
397541(PTGS1) 397590(PTGS2)
ECB: 
100034087(PTGS1) 791253(PTGS2)
MDO: 
100016747 100024802
SHR: 
100914094(PTGS1) 100926756(PTGS2)
OAA: 
100081492 100086096
GGA: 
396451(PTGS2) 427752(PTGS1)
MGP: 
100549847(PTGS1) 100550092
TGU: 
100221909(PTGS2) 100226968(PTGS1)
ACS: 
100558584(ptgs1) 100560130
XLA: 
100037245(ptgs1) 446781(ptgs2)
XTR: 
100493073(ptgs1) 595089(ptgs2)
DRE: 
246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
TRU: 
101064817 101071202
OLA: 
100359365(ptgs2) 101161174
BFO: 
BRAFLDRAFT_129952
CIN: 
100183010 100183175
API: 
100568622
SMP: 
SMAC_09193
PAN: 
PODANSg1229
MTM: 
MYCTH_2094824
MGR: 
MGG_10859
FGR: 
FG10960.1
NHE: 
NECHADRAFT_40259
VAL: 
VDBG_03337
SSL: 
SS1G_10705
BFU: 
BC1G_04254
ANI: 
AN5028.2
NFI: 
NFIA_045480 NFIA_065200
AFM: 
AFUA_3G12120
AOR: 
AOR_1_1372154(AO090003000772)
ANG: 
ANI_1_1118024(An02g07930)
AFV: 
AFLA_030430 AFLA_120760
ACT: 
ACLA_039980
PCS: 
Pc18g00240
CIM: 
CIMG_00042
CPW: 
CPC735_060720
PBL: 
PAAG_03986
URE: 
UREG_00168
ABE: 
ARB_07881
AJE: 
HCAG_01100
TML: 
GSTUM_00000322001
PPL: 
POSPLDRAFT_98495
LBC: 
LACBIDRAFT_305274 LACBIDRAFT_315146
CCI: 
CC1G_00844 CC1G_09914
SCM: 
SCHCODRAFT_11038 SCHCODRAFT_114799
UMA: 
UM04571.1
NEU: 
NE1240(Ptgs1)
MET: 
M446_1624
MNO: 
Mnod_6498
RSH: 
Rsph17029_3626
RSK: 
RSKD131_4262
RDE: 
RD1_1072
RLI: 
RLO149_c002730
MVA: 
Mvan_3099
MCB: 
Mycch_2784
SRO: 
Sros_8745
GOB: 
Gobs_1219
GLP: 
Glo7428_2177
NPU: 
Npun_R5469
NOS: 
Nos7107_2301
CSG: 
Cylst_1559
ONI: 
Osc7112_4273
MIC: 
Mic7113_3623
 » show all
Taxonomy
Reference
1  [PMID:3125548]
  Authors
DeWitt DL, Smith WL.
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 1412-6.
  Organism
Ovis aries
Reference
2  [PMID:104998]
  Authors
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
  Title
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
  Journal
J. Biol. Chem. 254 (1979) 829-36.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39391-18-9
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