| Entry |
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| Name |
heme oxygenase;
ORP33 proteins;
haem oxygenase;
heme oxygenase (decyclizing);
heme oxidase;
haem oxidase
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| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
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| Sysname |
heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
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| Reaction(IUBMB) |
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN: R00311]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The central iron is kept in the reduced state by NAD(P)H.
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| Pathway |
| Porphyrin and chlorophyll metabolism |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | CIN: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | API: | | PHU: | | NVE: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | OTA: | | CME: | | PIC: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | PTI: | | TPS: | | PIF: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | AOL: | | BSUB: | | BCZ: | | BCL: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SUY: | | SAUB: | | SAUM: | | CPE: | | CPF: | | CPR: | | CTC: | | CNO: | | MGI: | | MSP: | | MAB: | | MMV: | | ASD: | | CGL: | | CGB: | | CGU: | | CGT: | | CDI: | | CDP: | | CDH: | | CDT: | | CDE: | | CDR: | | CDA: | | CDZ: | | CDB: | | CDS: | | CDD: | | CDW: | | CDV: | | CJK: | | CUR: | | CUA: | | CAR: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | CVA: | | CHN: | | CCN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SCT: | | SCY: | | SFA: | | SBH: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | LXX: | | CMI: | | CMS: | | CMC: | | MTS: | | RSA: | | RMU: | | RDN: | | BCV: | | BFA: | | XCE: | | SKE: | | CFL: | | CFI: | | CGA: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | VMA: | | AMS: | | ASE: | | SNA: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | CHU: | | GFO: | | IPA: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | SYP: | | CYA: | | CYB: | | SYNE: | | SYNP: | | TEL: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CGC: | | CAN: | | CSN: | | DSL: | | HAO: | | GLP: | | CMP: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMA: | | PMM: | | PMT: | | PMN: | | PMI: | | PMB: | | PMC: | | PMF: | | PMG: | | PMH: | | PMJ: | | PME: | | TER: | | LEP: | | GEI: | | OAC: | | ONI: | | PSEU: | | CEP: | | MIC: | | ARP: | | CTHE: | | PLP: | | SCS: | | HYA: | | HHO: | | HYS: | |
» show all
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| Reference |
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| Authors |
Maines MD, Ibrahim NG, Kappas A. |
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| Title |
Solubilization and partial purification of heme oxygenase from rat liver. |
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| Journal |
J. Biol. Chem. 252 (1977) 5900-3. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Sunderman FW Jr, Downs JR, Reid MC, Bibeau LM. |
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| Title |
Gas-chromatographic assay for heme oxygenase activity. |
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| Journal |
Clin. Chem. 28 (1982) 2026-32. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Yoshida T, Takahashi S, Kikuchi G. |
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| Title |
Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes. |
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| Journal |
J. Biochem. (Tokyo). 75 (1974) 1187-91. |
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| Organism |
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| Reference |
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| Authors |
Noguchi M, Yoshida T, Kikuchi G. |
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| Title |
Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha. |
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| Journal |
FEBS. Lett. 98 (1979) 281-4. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Lad L, Schuller DJ, Shimizu H, Friedman J, Li H, Ortiz de Montellano PR, Poulos TL. |
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| Title |
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. |
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| Journal |
J. Biol. Chem. 278 (2003) 7834-43. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9059-22-7 |
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