| Entry |
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| Name |
aminobutyraldehyde dehydrogenase;
gamma-guanidinobutyraldehyde dehydrogenase (ambiguous);
ABAL dehydrogenase;
4-aminobutyraldehyde dehydrogenase;
4-aminobutanal dehydrogenase;
gamma-aminobutyraldehyde dehydroganase;
1-pyrroline dehydrogenase;
ABALDH;
YdcW
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
4-aminobutanal:NAD+ 1-oxidoreductase
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| Reaction(IUBMB) |
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN: R02549]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].
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| History |
EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)
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| Pathway |
| Arginine and proline metabolism | | beta-Alanine metabolism | | Metabolic pathways |
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| Orthology |
| aminobutyraldehyde dehydrogenase |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | ECOL: | | ECOI: | | ECOJ: | | ECOO: | | ECOH: | | ECOS: | | EFE: | | EAL: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SENR: | | SEND: | | SENI: | | SEEN: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEG: | | SEL: | | SEGA: | | SET: | | SENA: | | SENO: | | SENV: | | SENQ: | | SENL: | | SENJ: | | SEEC: | | SEEB: | | SENB: | | SENE: | | SENC: | | SES: | | SBG: | | SBZ: | | SBV: | | SFL: | | SFX: | | SFV: | | SFE: | | SFN: | | SFS: | | SSN: | | SDY: | | SDZ: | | SHQ: | | ENT: | | ENC: | | ENO: | | EEC: | | ENL: | | ECLG: | | ECLE: | | ECLN: | | ECLI: | | ECLX: | | ECLY: | | ECLZ: | | ECLA: | | ECLC: | | EAS: | | EAU: | | EHM: | | EKB: | | ELG: | | EXF: | | ECLS: | | ENR: | | ENX: | | ENF: | | ESA: | | CSK: | | CSZ: | | CSI: | | CSJ: | | CCON: | | CDM: | | CMJ: | | CUI: | | CMW: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNU: | | KPNK: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KMI: | | KOK: | | KOC: | | KOM: | | KQU: | | EAE: | | EAR: | | KQV: | | CKO: | | CRO: | | CFD: | | CBRA: | | CWE: | | CAMA: | | CAF: | | CIF: | | CFAR: | | CIR: | | GQU: | | EBT: | | ROR: | | RON: | | RPLN: | | CNT: | | CEM: | | CEN: | | CED: | | PGE: | | ESC: | | KLE: | | KSA: | | KOR: | | KRD: | | KIN: | | LAX: | | LEI: | | LEH: | | LAZ: | | LEF: | | LNI: | | EBF: | | SPE: | | SRL: | | SRY: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | SFW: | | SFG: | | SERA: | | SFO: | | ROX: | | ECA: | | PATR: | | PATO: | | PCT: | | PCC: | | PCV: | | PWA: | | PPAR: | | PEC: | | PWS: | | PPOA: | | SOD: | | DDA: | | DDD: | | DZE: | | DDC: | | DZC: | | DSO: | | DDQ: | | DFN: | | BGJ: | | HAV: | | OPO: | | PAU: | | PAG: | | PNC: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PRE: | | PALC: | | PCQ: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUD: | | PMON: | | PMOT: | | PMOS: | | PPJ: | | PFO: | | PFS: | | PFE: | | PFW: | | PFF: | | PFX: | | PMAN: | | PTV: | | PCG: | | PVR: | | PAZO: | | PEN: | | PBA: | | PBC: | | PPUU: | | PDR: | | PSV: | | PSK: | | PKC: | | PCH: | | PCZ: | | PCP: | | PALK: | | PSEM: | | PSEC: | | PSOS: | | PFK: | | PPSL: | | MSQ: | | MME: | | MPC: | | AHA: | | AHY: | | AHD: | | AHR: | | AHP: | | AHJ: | | AHH: | | AHI: | | AVR: | | AMED: | | ASR: | | AAJ: | | ADH: | | AEM: | | TSN: | | BMA: | | BML: | | BMN: | | BMAE: | | BMAI: | | BMAF: | | BMAZ: | | BMAB: | | BPS: | | BPM: | | BPL: | | BPD: | | BPSE: | | BPSM: | | BPSU: | | BPSD: | | BPZ: | | BPQ: | | BPK: | | BPSH: | | BPSA: | | BPSO: | | BUT: | | BTE: | | BTQ: | | BTJ: | | BTZ: | | BTD: | | BTV: | | BTHE: | | BTHM: | | BTHA: | | BTHL: | | BOK: | | BOC: | | BUR: | | BCON: | | BUB: | | BUL: | | BUD: | | ACHR: | | VEI: | | DTS: | | HYB: | | MEH: | | DAL: | | SUR: | | MLO: | | MLN: | | MCI: | | MOP: | | MAM: | | MAMO: | | MESO: | | MESW: | | HOE: | | AAK: | | PHT: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMER: | | SMD: | | RHI: | | SFH: | | SFD: | | SIX: | | SAME: | | SINO: | | EAD: | | EAH: | | ARA: | | AGC: | | RET: | | REC: | | REL: | | REI: | | REP: | | RLE: | | RLT: | | RLG: | | RLB: | | RLU: | | RTR: | | RHL: | | RGA: | | RHN: | | RPHA: | | RHX: | | SHZ: | | OAN: | | OAH: | | OPS: | | SNO: | | HMC: | | DEQ: | | MEY: | | MAAD: | | HDI: | | RHP: | | CEH: | | HAT: | | DAA: | | SPSE: | | ACR: | | AMV: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | AACE: | | TMO: | | APC: | | PGV: | | LPIL: | | MGO: | | MLL: | | MDX: | | CCG: | | CGY: | | CAMG: | | NFA: | | RHA: | | ROP: | | ROA: | | SBH: | | SVT: | | ARR: | | ARE: | | ARQ: | | ACH: | | GAR: | | CWO: | | TSC: | | MRB: | | MRE: | | MSV: | |
» show all
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| Reference |
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| Authors |
Callewaert DM, Rosemblatt MS, Tchen TT. |
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| Title |
Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species. |
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| Journal |
J. Biol. Chem. 249 (1974) 1737-41. |
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| Reference |
2 |
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| Authors |
Jakoby, W.B. |
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| Title |
Aldehyde dehydrogenases. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221. |
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| Reference |
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| Authors |
JAKOBY WB, FREDERICKS J. |
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| Title |
Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase. |
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| Journal |
J. Biol. Chem. 234 (1959) 2145-50. |
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| Reference |
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| Authors |
Matsuda H, Suzuki Y. |
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| Title |
gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves. |
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| Journal |
Plant. Physiol. 76 (1984) 654-657. |
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| Reference |
5 |
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| Authors |
Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K. |
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| Title |
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida. |
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| Journal |
Agric. Biol. Chem. 50 (1986) 2009-2016. |
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| Reference |
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| Authors |
Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A. |
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| Title |
A pathway for putrescine catabolism in Escherichia coli. |
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| Journal |
Biochim. Biophys. Acta. 880 (1986) 242-4. |
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| Reference |
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| Authors |
Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A. |
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| Title |
Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli. |
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| Journal |
Biochimie. 69 (1987) 1161-8. |
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| Reference |
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| Authors |
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR. |
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| Title |
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase. |
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| Journal |
FEBS. Lett. 579 (2005) 4107-12. |
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| Sequence |
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| Reference |
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| Authors |
Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C |
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| Title |
Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase. |
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| Journal |
J. Mol. Biol. 343 (2004) 29-41. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9028-98-2 |
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