aminobutyraldehyde dehydrogenase;
gamma-guanidinobutyraldehyde dehydrogenase (ambiguous);
ABAL dehydrogenase;
4-aminobutyraldehyde dehydrogenase;
4-aminobutanal dehydrogenase;
gamma-aminobutyraldehyde dehydroganase;
1-pyrroline dehydrogenase;
ABALDH;
YdcW

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

4-aminobutanal:NAD+ 1-oxidoreductase

4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN:R02549]

R02549;
(other) R00904

4-aminobutanal [CPD:C00555];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].

EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)

1  [PMID:4817964]

Callewaert DM, Rosemblatt MS, Tchen TT.

Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species.

J. Biol. Chem. 249 (1974) 1737-41.

Pseudomonas sp.

2

Jakoby, W.B.

Aldehyde dehydrogenases.

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.

3  [PMID:13673029]

JAKOBY WB, FREDERICKS J.

Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase.

J. Biol. Chem. 234 (1959) 2145-50.

Pseudomonas fluorescens

4  [PMID:16663901]

Matsuda H, Suzuki Y.

gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves.

Plant. Physiol. 76 (1984) 654-657.

Vicia faba

5

Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K.

4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida.

Agric. Biol. Chem. 50 (1986) 2009-2016.

6  [PMID:3510672]

Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A.

A pathway for putrescine catabolism in Escherichia coli.

Biochim. Biophys. Acta. 880 (1986) 242-4.

Escherichia coli

7  [PMID:3129020]

Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A.

Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.

Biochimie. 69 (1987) 1161-8.

Escherichia coli

8  [PMID:16023116]

Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR.

Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.

FEBS. Lett. 579 (2005) 4107-12.

Escherichia coli

[eco:b1444]

9  [PMID:15381418]

Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C

Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase.

J. Mol. Biol. 343 (2004) 29-41.

Escherichia coli

[eco:b1444]