KEGG   ENZYME: 1.2.1.24Help
Entry
EC 1.2.1.24                 Enzyme                                 

Name
succinate-semialdehyde dehydrogenase (NAD+);
succinate semialdehyde dehydrogenase (NAD+);
succinic semialdehyde dehydrogenase (NAD+);
succinyl semialdehyde dehydrogenase (NAD+);
succinate semialdehyde:NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ [RN:R00713]
Reaction(KEGG)
Substrate
succinate semialdehyde [CPD:C00232];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
succinate [CPD:C00042];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
History
EC 1.2.1.24 created 1972, modified 2010
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00650  Butanoate metabolism
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K00139  succinate-semialdehyde dehydrogenase
K08324  succinate-semialdehyde dehydrogenase
K17761  succinate-semialdehyde dehydrogenase, mitochondrial
Genes
HSA: 7915(ALDH5A1)
PTR: 449515(ALDH5A1)
PPS: 100973567(ALDH5A1)
PON: 100458767(ALDH5A1)
NLE: 100598672(ALDH5A1)
MCC: 707902(ALDH5A1)
MCF: 102126652(ALDH5A1)
CSAB: 103222054(ALDH5A1)
RRO: 104663880(ALDH5A1)
RBB: 108533666(ALDH5A1)
CJC: 100411976(ALDH5A1)
SBQ: 101032615(ALDH5A1)
MMU: 214579(Aldh5a1)
RNO: 291133(Aldh5a1)
CGE: 100764462(Aldh5a1)
NGI: 103745192(Aldh5a1)
HGL: 101723101(Aldh5a1)
OCU: 100351836(ALDH5A1)
TUP: 102502332(ALDH5A1)
CFA: 488246(ALDH5A1)
AML: 100484592(ALDH5A1)
UMR: 103665177(ALDH5A1)
ORO: 101383029(ALDH5A1)
FCA: 101088238(ALDH5A1)
PTG: 102964382(ALDH5A1)
AJU: 106968435(ALDH5A1)
BTA: 532724(ALDH5A1)
BOM: 106701204(ALDH5A1)
BIU: 109577165(ALDH5A1)
PHD: 102339891(ALDH5A1)
CHX: 102169437(ALDH5A1)
OAS: 101107828(ALDH5A1)
SSC: 100157072(ALDH5A1)
CFR: 102518028(ALDH5A1)
CDK: 105089130(ALDH5A1)
BACU: 103016976(ALDH5A1)
LVE: 103088365(ALDH5A1)
OOR: 101288482(ALDH5A1)
ECB: 100067559(ALDH5A1)
EPZ: 103546699(ALDH5A1)
EAI: 106822356(ALDH5A1)
MYB: 102260777(ALDH5A1)
MYD: 102753126(ALDH5A1)
HAI: 109396396(ALDH5A1)
RSS: 109437529(ALDH5A1) 109440802
PALE: 102896629(ALDH5A1)
LAV: 100665909(ALDH5A1)
TMU: 101343803
MDO: 100024272(ALDH5A1)
SHR: 100931547(ALDH5A1)
GGA: 420818(ALDH5A1)
MGP: 100546241(ALDH5A1)
CJO: 107309742(ALDH5A1)
APLA: 101793939(ALDH5A1)
ACYG: 106038363(ALDH5A1)
TGU: 100222151(ALDH5A1)
GFR: 102039068(ALDH5A1)
FAB: 101808132(ALDH5A1)
PHI: 102114491(ALDH5A1)
PMAJ: 107215792(ALDH5A1)
CCW: 104691447(ALDH5A1)
FPG: 101913385(ALDH5A1)
FCH: 102046638(ALDH5A1)
CLV: 102091200(ALDH5A1)
EGZ: 104125447(ALDH5A1)
AAM: 106483255(ALDH5A1)
ASN: 102378246(ALDH5A1)
AMJ: 102577046(ALDH5A1)
PSS: 102449242(ALDH5A1)
CMY: 102931386(ALDH5A1)
CPIC: 101945488(ALDH5A1)
ACS: 100567651(aldh5a1)
PVT: 110072879(ALDH5A1)
PBI: 103063078(ALDH5A1)
GJA: 107113410(ALDH5A1)
XLA: 108719155(aldh5a1.L) 108720127(aldh5a1.S)
XTR: 100216127(aldh5a1)
NPR: 108792900(ALDH5A1)
DRE: 565235(aldh5a1)
CCAR: 109106577
IPU: 108270702(aldh5a1)
AMEX: 103033070(aldh5a1)
TRU: 101064243(aldh5a1)
LCO: 104933853(aldh5a1)
NCC: 104948663(aldh5a1)
MZE: 101464303(aldh5a1)
OLA: 101159164(aldh5a1)
XMA: 102225683(aldh5a1)
PRET: 103477483(aldh5a1)
NFU: 107379020(aldh5a1)
CSEM: 103388970(aldh5a1)
HCQ: 109512139(aldh5a1)
BPEC: 110157886(aldh5a1)
SASA: 106605473(SSDH)
ELS: 105019234(aldh5a1)
SFM: 108940701(aldh5a1)
LCM: 102345816(ALDH5A1)
CMK: 103184917(aldh5a1)
SPU: 584281
APLC: 110989753
SKO: 100367735
DME: Dmel_CG4685(Ssadh)
DSI: Dsimw501_GD18186(Dsim_GD18186)
MDE: 101900308
AAG: 5565255
AME: 412305(Ssadh)
BIM: 100750149
BTER: 100648985
SOC: 105200884
AEC: 105143617
ACEP: 105620176
PBAR: 105430507
HST: 105186718
CFO: 105255355
LHU: 105674093
PGC: 109854973
NVI: 100117954
TCA: 661308
NVL: 108567416
BMOR: 101744102
PMAC: 106714089
PRAP: 110993252
PXY: 105392542
API: 100160792
DNX: 107173419
ZNE: 110831901
TUT: 107371700
CEL: CELE_F45H10.1(alh-7)
CBR: CBG20774(Cbr-alh-7)
BMY: Bm1_35520
TSP: Tsp_07602
MYI: 110455008
OBI: 106879957
SHX: MS3_09350
ADF: 107331082
HMG: 100208673
ATH: AT1G79440(ALDH5F1)
CRB: 17894487
BRP: 103832421
THJ: 104808138
CPAP: 110817264
CIT: 102625593
TCC: 18594997
GRA: 105782967
EGR: 104451041
VRA: 106761951
VAR: 108333866
CCAJ: 109805768
CAM: 101506901
ADU: 107458746
AIP: 107612919
LJA: Lj3g3v0948280.2(Lj3g3v0948280.2)
FVE: 101300512
PPER: 18778265
PMUM: 103325589
PAVI: 110770542
MDM: 103419798
ZJU: 107424726
CSV: 101217352
CMO: 103496279
MCHA: 111018025
RCU: 8279668
JCU: 105641372
HBR: 110660672
POP: 7481606
SLY: 100147726(SSADH)
SPEN: 107031056
SOT: 102597977
CANN: 107864249
NSY: 104238267
NTO: 104088088
INI: 109190816
SIND: 105175117
OEU: 111382263
LSV: 111884961
BVG: 104906363
SOE: 110803266
NNU: 104605350
OSA: 9267109
DOSA: Os02t0173900-01(Os02g0173900)
OBR: 102706353
BDI: 100839823
ATS: 109735776(LOC109735776)
SBI: 110434633
SITA: 101782853
PDA: 103721452
EGU: 105039716
MUS: 103986300
DCT: 110098431
AOF: 109844720
ATR: 18421656
ECO: b1525(sad)
ECJ: JW5247(yneI)
ECD: ECDH10B_1656(yneI)
EBW: BWG_1344(sad)
ECOK: ECMDS42_1236(yneI)
ECE: Z2178(yneI)
ECS: ECs2132
ETW: ECSP_2010(yneI)
EOJ: ECO26_2126(yneI)
EOI: ECO111_1921(yneI)
EOH: ECO103_1655(yneI)
ECG: E2348C_1646(yneI)
EOK: G2583_1890(yneI)
ECC: c1948(yneI)
ECP: ECP_1509
ECI: UTI89_C1744(yneI)
ECV: APECO1_645(yneI)
ECY: ECSE_1615
ECR: ECIAI1_1537(yneI)
ECQ: ECED1_1654(yneI)
ECK: EC55989_1658(yneI)
ECT: ECIAI39_1789(yneI)
EOC: CE10_1714(sad)
EUM: ECUMN_1793(yneI)
ECZ: ECS88_1602(yneI)
ELH: ETEC_1595
ESE: ECSF_1423
ESO: O3O_12780
ESM: O3M_12815
ESL: O3K_12855
EBR: ECB_01482(yneI)
EBD: ECBD_2117
EKF: KO11_15540(sad)
EAB: ECABU_c17520(yneI)
EDJ: ECDH1ME8569_1468(sad)
ELW: ECW_m1654(sad)
ELL: WFL_08100(sad)
ELC: i14_1769(yneI)
ELD: i02_1769(yneI)
ELP: P12B_c1552(yneI)
EBL: ECD_01482(sad)
EBE: B21_01493(sad)
ELF: LF82_3565(yneI)
ECOI: ECOPMV1_01652(sad)
ECOJ: P423_08375
ECOO: ECRM13514_1865(yneI)
ECOH: ECRM13516_1891(yneI)
ECOS: EC958_1781(yneI)
EFE: EFER_1549(yneI)
STY: STY1536
STT: t1445
STM: STM1524(yneI)
SEO: STM14_1842(yneI)
SEY: SL1344_1454(yneI)
SEJ: STMUK_1489(yneI)
SEB: STM474_1535(yneI)
SENI: CY43_07765
SPT: SPA1331(yneI)
SEK: SSPA1236
SEI: SPC_2204(yneI)
SEC: SCH_1541(yneI)
SHB: SU5_02134
SENS: Q786_07620
SED: SeD_A1811
SEG: SG1595(yneI)
SEL: SPUL_1342(yneI)
SEGA: SPUCDC_1342(yneI)
SET: SEN1527(yneI)
SENA: AU38_07885
SENO: AU37_07885
SENV: AU39_07895
SENQ: AU40_08835
SENL: IY59_08080
SENE: IA1_07545
SBG: SBG_1350
SBZ: A464_1545
SFE: SFxv_1759(sad)
SFN: SFy_2249
SFS: SFyv_2304
SFT: NCTC1_01701(sad)
SSN: SSON_1603
SBO: SBO_1643
SDY: SDY_1632
ENC: ECL_01992
ECLO: ENC_10690
EEC: EcWSU1_02182(yneI)
ECLX: LI66_10735
ECLY: LI62_11525
ECLZ: LI64_11530
ESA: ESA_01815
CSK: ES15_1970(yneI)
CTU: CTU_21660(yneI)
KPN: KPN_01635(yneI)
KPU: KP1_2675(yneI)
KPP: A79E_2593
KPE: KPK_2744
KPR: KPR_2533(yneI)
KPJ: N559_2675
KPX: PMK1_03964(sad_2)
KPNU: LI86_13335
KPNK: BN49_2739(yneI)
KVA: Kvar_2699
KOX: KOX_21255
KOE: A225_3111
EAE: EAE_18620
EAR: CCG30165
CKO: CKO_01545
CRO: ROD_15181
CAMA: F384_06955
EBF: D782_2190
RAA: Q7S_24296
ETA: ETA_07770(aldD)
EPY: EpC_pEp360210(aldD)
EPR: EPYR_03994(aldD)
EAM: EAMY_3719(aldD)
EAY: EAM_P111
EBI: EbC_22560(aldD)
ERJ: EJP617_A190(aldD)
EGE: EM595_0230(sad)
PAM: PANA_4185(yneI)
PLF: PANA5342_p10326(yneI)
PAJ: PAJ_p0100(yneI)
PAQ: PAGR_p251
PVA: Pvag_pPag30001(yneI)
PSTW: DSJ_25850
SML: Smlt2230
SMT: Smal_1825
SMZ: SMD_2011
PCQ: PcP3B5_30090(sad)
PPU: PP_3151(sad-II)
PPF: Pput_2563
PPT: PPS_2775
PPI: YSA_10621
PPX: T1E_1072(yneI)
PPUH: B479_13530
PPUT: L483_17710
PPUN: PP4_25230
PPUD: DW66_3034
PMON: X969_13235
PMOT: X970_12880
PSB: Psyr_2394
PSYR: N018_15340
PFL: PFL_3831(yneI)
PPRC: PFLCHA0_c38890(yneI)
PPRO: PPC_3932(yneI)
PFS: PFLU_4212
PFC: PflA506_3525(yneI)
PFW: PF1751_v1c37170(yneI)
PFB: VO64_1287
PMAN: OU5_5997
PEN: PSEEN2895
PKC: PKB_2932(sad)
PSES: PSCI_5021
PSEM: TO66_15815
PSEC: CCOS191_2818(sad)
PSOS: POS17_3953(yneI)
PANR: A7J50_3890
PSET: THL1_2882
PSIL: PMA3_13685
NMA: NMA1565
NME: NMB1353
NMP: NMBB_1497
NMC: NMC1288
NMN: NMCC_1264
NMT: NMV_1045
NMI: NMO_1189
NMW: NMAA_1080
NGO: NGO0665
NGK: NGK_1242
NLA: NLA_11850
ECOR: SAMEA4412678_0321(sad)
CVI: CV_4092
PSE: NH8B_3619
BCJ: BCAL1183
BCT: GEM_5507
BGO: BM43_5732
BHO: D560_3896(sad)
BHM: D558_3867(sad)
AAY: WYH_01855(sad)
 » show all
Taxonomy
Reference
1  [PMID:13860092]
  Authors
ALBERS RW, KOVAL GJ.
  Title
Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain.
  Journal
Biochim. Biophys. Acta. 52 (1961) 29-35.
Reference
2  [PMID:3190233]
  Authors
Ryzlak MT, Pietruszko R
  Title
Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase.
  Journal
Arch. Biochem. Biophys. 266 (1988) 386-96.
Reference
3  [PMID:10517851]
  Authors
Busch KB, Fromm H
  Title
Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides.
  Journal
Plant. Physiol. 121 (1999) 589-97.
  Sequence
[ath:AT1G79440]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.24
IUBMB Enzyme Nomenclature: 1.2.1.24
ExPASy - ENZYME nomenclature database: 1.2.1.24
BRENDA, the Enzyme Database: 1.2.1.24
CAS: 9028-95-9

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