KEGG   ENZYME: 1.2.1.25Help
Entry
EC 1.2.1.25                 Enzyme                                 

Name
2-oxoisovalerate dehydrogenase (acylating);
2-oxoisovalerate dehydrogenase;
alpha-ketoisovalerate dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)
Reaction(IUBMB)
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH [RN:R01210]
Reaction(KEGG)
R01210;
(other) R01651 R03171
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Substrate
3-methyl-2-oxobutanoate [CPD:C00141];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
2-methylpropanoyl-CoA [CPD:C00630];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate.
History
EC 1.2.1.25 created 1972
Reference
1  [PMID:4308861]
  Authors
Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T.
  Title
Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis.
  Journal
J. Biol. Chem. 244 (1969) 4437-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37211-61-3

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