KEGG   ENZYME: 1.2.1.26Help
Entry
EC 1.2.1.26                 Enzyme                                 

Name
2,5-dioxovalerate dehydrogenase;
2-oxoglutarate semialdehyde dehydrogenase;
alpha-ketoglutaric semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,5-dioxopentanoate:NADP+ 5-oxidoreductase
Reaction(IUBMB)
2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + 2 H+ [RN:R00264]
Reaction(KEGG)
Substrate
2,5-dioxopentanoate [CPD:C00433];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.26 created 1972
Pathway
Ascorbate and aldarate metabolism
Orthology
K13877  
alpha-ketoglutaric semialdehyde dehydrogenase
Genes
BTE: 
BTD: 
BPH: 
Taxonomy
Reference
1  [PMID:6024771]
  Authors
Adams E, Rosso G
  Title
Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes.
  Journal
J. Biol. Chem. 242 (1967) 1802-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-92-3

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