KEGG   ENZYME: 1.2.1.31Help
Entry
EC 1.2.1.31                 Enzyme                                 
Name
L-aminoadipate-semialdehyde dehydrogenase;
aminoadipate semialdehyde dehydrogenase;
2-aminoadipate semialdehyde dehydrogenase;
alpha-aminoadipate-semialdehyde dehydrogenase;
alpha-aminoadipate reductase;
2-aminoadipic semialdehyde dehydrogenase;
L-alpha-aminoadipate delta-semialdehyde oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase;
L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R03102 R03103]
Reaction(KEGG)
Substrate
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-2-aminoadipate [CPD:C00956];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway
Lysine biosynthesis
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00143  
L-aminoadipate-semialdehyde dehydrogenase
K14085  
aldehyde dehydrogenase family 7 member A1
Genes
HSA: 
501(ALDH7A1)
PTR: 
462033(ALDH7A1)
PPS: 
100970731(ALDH7A1)
GGO: 
101148545(ALDH7A1)
PON: 
100461726(ALDH7A1)
MCC: 
702749(ALDH7A1) 716090
MMU: 
110695(Aldh7a1)
RNO: 
291450(Aldh7a1)
CFA: 
481486(ALDH7A1)
AML: 
100475712(ALDH7A1)
FCA: 
101086623(ALDH7A1)
BTA: 
507477(ALDH7A1)
SSC: 
100515532
ECB: 
100063766(ALDH7A1)
MDO: 
100009965
SHR: 
100930576(ALDH7A1)
OAA: 
100074256(ALDH7A1)
GGA: 
426812(ALDH7A1)
TGU: 
100223716(ALDH7A1)
ACS: 
100560663
XLA: 
447522(aldh7a1)
XTR: 
549131(aldh7a1)
DRE: 
334197(aldh7a1)
TRU: 
101066288
OLA: 
101157525
BFO: 
BRAFLDRAFT_114917
CIN: 
100184485
SPU: 
588376
DME: 
Dmel_CG9629
DPO: 
Dpse_GA21924
DAN: 
Dana_GF10773
DER: 
Dere_GG13416
DPE: 
Dper_GL20912
DSE: 
Dsec_GM14883
DSI: 
Dsim_GD12292
DWI: 
Dwil_GK19673
DYA: 
Dyak_GE22513
DGR: 
Dgri_GH14418
DMO: 
Dmoj_GI13547
DVI: 
Dvir_GJ11906
AGA: 
AgaP_AGAP000881
AAG: 
AaeL_AAEL011756
CQU: 
CpipJ_CPIJ009438
AME: 
411140
NVI: 
100499205
TCA: 
658395
API: 
100159019
PHU: 
Phum_PHUM233600
ISC: 
IscW_ISCW020189
CEL: 
CELE_F01F1.6(alh-9)
CBR: 
CBG09070(Cbr-alh-9)
NVE: 
NEMVE_v1g175287
HMG: 
100198995(aldh7a1)
TAD: 
TRIADDRAFT_35608
AQU: 
100634152
ATH: 
AT1G54100(ALDH7B4)
ALY: 
ARALYDRAFT_474541
GMX: 
100811186
MTR: 
MTR_2g042330
CSV: 
101205436
RCU: 
RCOM_0083650
POP: 
POPTR_745820 POPTR_853157
VVI: 
100252622 100261802
OSA: 
4347172
DOSA: 
Os09t0440300-01(Os09g0440300)
BDI: 
100831288
SBI: 
SORBI_02g025790(SORBIDRAFT_02g025790)
ZMA: 
100282748
SMO: 
SELMODRAFT_164276 SELMODRAFT_230941
PPP: 
PHYPADRAFT_110382(ALDH7A)
SCE: 
YBR115C(LYS2)
AGO: 
AGOS_ADL346W
ERC: 
Ecym_3457
KLA: 
KLLA0B09218g
LTH: 
KLTH0F10384g
PPA: 
PAS_chr1-4_0153
VPO: 
Kpol_1006p6
ZRO: 
ZYRO0C16566g
CGR: 
CAGL0K07788g
NCS: 
NCAS_0I01040(NCAS0I01040)
NDI: 
NDAI_0A07970(NDAI0A07970)
TPF: 
TPHA_0A03520(TPHA0A03520)
TBL: 
TBLA_0H01500(TBLA0H01500)
TDL: 
TDEL_0C05110(TDEL0C05110)
KAF: 
KAFR_0D02630(KAFR0D02630)
DHA: 
DEHA2D07964g
PIC: 
PICST_68020(LYS2)
PGU: 
PGUG_04759
LEL: 
LELG_01517
CAL: 
CaO19.10487(LYS2) CaO19.2970(LYS2)
CTP: 
CTRG_04682
CDU: 
CD36_02620
COT: 
CORT_0B09490
YLI: 
YALI0E06457g
CLU: 
CLUG_04446
NCR: 
NCU03010
SMP: 
SMAC_01210
PAN: 
PODANSg09765
TTT: 
THITE_2122221
MTM: 
MYCTH_2295392
MGR: 
MGG_02611
FGR: 
FG06041.1
NHE: 
NECHADRAFT_76435(NhLYS2)
VAL: 
VDBG_05463
SSL: 
SS1G_08185
BFU: 
BC1G_13197
ANI: 
AN5610.2
NFI: 
NFIA_105160
AFM: 
AFUA_4G11240
AOR: 
AOR_1_1954154(AO090003001097)
ANG: 
ANI_1_1902184(An04g05420)
AFV: 
AFLA_027230
ACT: 
ACLA_050330
PCS: 
Pc22g06310(Lys2)
CIM: 
CIMG_01491
CPW: 
CPC735_049520
PBL: 
PAAG_08023
URE: 
UREG_05106
ABE: 
ARB_02279
TVE: 
TRV_04974
AJE: 
HCAG_09107
PNO: 
SNOG_07784
PTE: 
PTT_09387
ZTR: 
MYCGRDRAFT_99148(LYS2)
TML: 
GSTUM_00010502001
SPO: 
SPAP7G5.04c(lys1)
CNE: 
CNG00170
CNB: 
CNBA6940 CNBG4570
CGI: 
CGB_A8240C CGB_G6500C
LBC: 
LACBIDRAFT_184376(LbLYS1) LACBIDRAFT_248281
MPR: 
MPER_07485 MPER_08765
CCI: 
CC1G_06909 CC1G_15694
SCM: 
SCHCODRAFT_59997 SCHCODRAFT_68486
UMA: 
UM01697.1
MGL: 
MGL_0235
PGR: 
PGTG_07683
MBR: 
MONBRDRAFT_14686 MONBRDRAFT_37970
NGR: 
NAEGRDRAFT_35633 NAEGRDRAFT_77825
DDI: 
DDB_G0276821
DPP: 
DICPUDRAFT_151785
TET: 
TTHERM_00678220
PTM: 
GSPATT00002104001
PIF: 
PITG_05462
 » show all
Taxonomy
Reference
1  [PMID:4285660]
  Authors
Calvert AF, Rodwell VW.
  Title
Metabolism of pipecolic acid in a Pseudomonas species. 3. L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase.
  Journal
J. Biol. Chem. 241 (1966) 409-14.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9067-87-2
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