| Entry |
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| Name |
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase;
carboxymethylhydroxymuconic semialdehyde dehydrogenase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
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| Reaction(IUBMB) |
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+ [RN: R04418]
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| Reaction(KEGG) |
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| Substrate |
5-carboxymethyl-2-hydroxymuconate semialdehyde [CPD: C04642];
H2O [CPD: C00001];
NAD+ [CPD: C00003]
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| Product |
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| Comment |
Involved in the tyrosine degradation pathway in Arthrobacter sp.
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| Pathway |
| Tyrosine metabolism | | Microbial metabolism in diverse environments |
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| Orthology |
| 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |
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| Genes |
EOJ: | | EOI: | | EOH: | | ECX: | | ECY: | | ECR: | | EUM: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | ELW: | | ELL: | | EBL: | | EBE: | | ECOA: | | EFE: | | EBT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | PLU: | | PAY: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | XBO: | | XNE: | | PSI: | | ROR: | | EBF: | | PMU: | | PMV: | | PUL: | | PMP: | | FAU: | | VVY: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PSG: | | PPG: | | PFL: | | PFS: | | PFE: | | PFC: | | PEN: | | PBA: | | PDR: | | AVN: | | ADI: | | MMW: | | RPI: | | RPF: | | BMA: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BTD: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPY: | | BUG: | | BGE: | | BGF: | | BRH: | | BUK: | | BPX: | | BBR: | | BBM: | | BBH: | | BAV: | | AXY: | | AAA: | | DAC: | | DEL: | | VAP: | | VPE: | | RTA: | | MPT: | | AZO: | | MCI: | | MOP: | | MES: | | PLA: | | RHI: | | SFH: | | RLT: | | RTR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMB: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPD: | | RPT: | | RPX: | | AOL: | | SIL: | | SIT: | | JAN: | | PGA: | | PGL: | | SWI: | | MAG: | | PGV: | | BCY: | | OIH: | | GKA: | | GTN: | | GTH: | | GTE: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | HHD: | | AAC: | | AAD: | | BTS: | | TMR: | | SAY: | | SAP: | | MMC: | | MKM: | | MJL: | | CAR: | | CHN: | | NFA: | | NBR: | | ROP: | | GPO: | | SCB: | | SVL: | | SHY: | | SHO: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | BCV: | | IVA: | | CFI: | | ICA: | | SRO: | | SESP: | | STI: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | TRA: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | MRB: | | MRE: | | MSV: | | MHD: | |
» show all
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| Reference |
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| Authors |
Blakley ER. |
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| Title |
The catabolism of L-tyrosine by an Arthrobacter sp. |
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| Journal |
Can. J. Microbiol. 23 (1977) 1128-39. |
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| Organism |
Arthrobacter sp. |
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| Reference |
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| Authors |
Alonso JM, Garrido-Pertierra A. |
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| Title |
Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. |
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| Journal |
Biochim. Biophys. Acta. 719 (1982) 165-7. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Cooper RA, Skinner MA. |
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| Title |
Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli. |
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| Journal |
J. Bacteriol. 143 (1980) 302-6. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Garrido-Peritierra A, Cooper RA |
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| Title |
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. |
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| Journal |
Eur. J. Biochem. 117 (1981) 581-4. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 63241-20-3 |
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