KEGG   ENZYME: 1.2.1.69Help
Entry
EC 1.2.1.69                 Enzyme                                 

Name
fluoroacetaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
fluoroacetaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+ [RN:R07156]
Reaction(KEGG)
Substrate
fluoroacetaldehyde [CPD:C15488];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
fluoroacetate [CPD:C06108];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
History
EC 1.2.1.69 created 2003
Reference
1  [PMID:11571203]
  Authors
Murphy CD, Moss SJ, O'Hagan D.
  Title
Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya.
  Journal
Appl. Environ. Microbiol. 67 (2001) 4919-21.
Reference
2  [PMID:12738270]
  Authors
Murphy CD, Schaffrath C, O'Hagan D.
  Title
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.
  Journal
Chemosphere. 52 (2003) 455-61.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
387336-50-7

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