KEGG   ENZYME: 1.2.1.76Help
Entry
EC 1.2.1.76                 Enzyme                                 

Name
succinate-semialdehyde dehydrogenase (acylating);
succinyl-coA reductase;
coenzyme-A-dependent succinate-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ [RN:R09280]
Reaction(KEGG)
Substrate
succinate semialdehyde [CPD:C00232];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
succinyl-CoA [CPD:C00091];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].
History
EC 1.2.1.76 created 2009
Pathway
Butanoate metabolism
Carbon fixation pathways in prokaryotes
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K15017  
malonyl-CoA/succinyl-CoA reductase (NADPH)
K15038  
succinyl-CoA reductase
K18119  
succinate-semialdehyde dehydrogenase
Genes
CKL: 
CKL_3015(sucD)
CKR: 
CDF: 
CDC: 
CDL: 
CDG: 
HAS: 
PGI: 
PG0687(sucD)
PGN: 
PGT: 
PAH: 
OSP: 
TFO: 
SSO: 
SSO1629(gapN-1) SSO1842(gapN-2) SSO2178(asd-2)
SOL: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PIS: 
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TNE: 
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 » show all
Taxonomy
Reference
1  [PMID:8444151]
  Authors
Sohling B, Gottschalk G
  Title
Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.
  Journal
Eur. J. Biochem. 212 (1993) 121-7.
Reference
2  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J. Bacteriol. 188 (2006) 8551-9.
Reference
3  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
  Sequence
[mse:Msed_0709]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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