KEGG   ENZYME: 1.2.99.8Help
Entry
EC 1.2.99.8                 Enzyme                                 

Name
glyceraldehyde dehydrogenase (FAD-containing);
glyceraldehyde oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)
Reaction(IUBMB)
D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor [RN:R10324]
Reaction(KEGG)
Substrate
D-glyceraldehyde [CPD:C00577];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
D-glycerate [CPD:C00258];
reduced acceptor [CPD:C00030]
Comment
The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide.
History
EC 1.2.99.8 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18020  glyceraldehyde dehydrogenase large subunit
K18021  glyceraldehyde dehydrogenase medium subunit
K18022  glyceraldehyde dehydrogenase small subunit
Genes
APE: APE_0708.1
SSO: SSO2636(cutB-2) SSO2637(cutC-2) SSO2639(cutA-4)
SOL: Ssol_0448 Ssol_0449 Ssol_0450
SSOA: SULA_0441 SULA_0442 SULA_0443
SSOL: SULB_0443 SULB_0444 SULB_0445
SSOF: SULC_0441 SULC_0442 SULC_0443
STO: STK_17810 STK_17820 STK_17830
SAI: Saci_2269(cutB) Saci_2270(cutC) Saci_2271(cutA)
SACN: SacN8_11060 SacN8_11065 SacN8_11070
SACR: SacRon12I_11305 SacRon12I_11310 SacRon12I_11315
 » show all
Taxonomy
Reference
1  [PMID:10095793]
  Authors
Kardinahl S, Schmidt CL, Hansen T, Anemuller S, Petersen A, Schafer G
  Title
The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing  enzyme--an aldehyde oxidoreductase.
  Journal
Eur. J. Biochem. 260 (1999) 540-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.99.8
IUBMB Enzyme Nomenclature: 1.2.99.8
ExPASy - ENZYME nomenclature database: 1.2.99.8
BRENDA, the Enzyme Database: 1.2.99.8

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