KEGG   ENZYME: 1.2.99.8Help
Entry
EC 1.2.99.8                 Enzyme                                 

Name
glyceraldehyde dehydrogenase (FAD-containing);
glyceraldehyde oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)
Reaction(IUBMB)
D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor [RN:R10324]
Reaction(KEGG)
Substrate
D-glyceraldehyde [CPD:C00577];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
D-glycerate [CPD:C00258];
reduced acceptor [CPD:C00030]
Comment
The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide.
History
EC 1.2.99.8 created 2013
Pathway
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18020  
glyceraldehyde dehydrogenase large subunit
K18021  
glyceraldehyde dehydrogenase medium subunit
K18022  
glyceraldehyde dehydrogenase small subunit
Genes
APE: 
SSO: 
SSO2636(cutB-2) SSO2637(cutC-2) SSO2639(cutA-4)
SOL: 
STO: 
SAI: 
Saci_2269(cutB) Saci_2270(cutC) Saci_2271(cutA)
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
 » show all
Taxonomy
Reference
1  [PMID:10095793]
  Authors
Kardinahl S, Schmidt CL, Hansen T, Anemuller S, Petersen A, Schafer G
  Title
The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing  enzyme--an aldehyde oxidoreductase.
  Journal
Eur. J. Biochem. 260 (1999) 540-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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