KEGG   ENZYME: 1.3.3.6Help
Entry
EC 1.3.3.6                  Enzyme                                 
Name
acyl-CoA oxidase;
fatty acyl-CoA oxidase;
acyl coenzyme A oxidase;
fatty acyl-coenzyme A oxidase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
acyl-CoA:oxygen 2-oxidoreductase
Reaction(IUBMB)
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
O2 [CPD:C00007]
Product
trans-2,3-dehydroacyl-CoA [CPD:C00658];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.
Pathway
Fatty acid metabolism
alpha-Linolenic acid metabolism
Biosynthesis of unsaturated fatty acids
Metabolic pathways
Orthology
K00232  
acyl-CoA oxidase
Genes
HSA: 
51(ACOX1) 8310(ACOX3)
PTR: 
454895(ACOX1) 461115(ACOX3)
PPS: 
100973171(ACOX3) 100984758(ACOX1)
GGO: 
101145668(ACOX1) 101152360(ACOX3)
PON: 
MCC: 
705197(ACOX1) 722634(ACOX3)
MMU: 
11430(Acox1) 80911(Acox3)
RNO: 
50681(Acox1) 83522(Acox3)
CFA: 
483322(ACOX1) 488790(ACOX3)
AML: 
100463549(ACOX3) 100471606(ACOX1)
FCA: 
101082279(ACOX1) 101088745(ACOX3)
BTA: 
510065(ACOX3) 513996(ACOX1)
SSC: 
100113422(ACOX1) 100523005(ACOX3)
ECB: 
100051466(ACOX1) 100056690(ACOX3)
MDO: 
100019995(ACOX3) 100022432(ACOX1)
SHR: 
100926515
OAA: 
100083493
GGA: 
417366(ACOX1) 422869(ACOX3)
MGP: 
100538886 100540963(ACOX1)
TGU: 
100224774(ACOX3) 100230333(ACOX1)
ACS: 
100560789(acox3) 100562736(acox1)
XLA: 
403357 735228(acox1)
XTR: 
100380064(acox3) 548479(acox1)
DRE: 
406421(acox3) 449662(acox1)
TRU: 
101077705
OLA: 
101166187 101168603
BFO: 
BRAFLDRAFT_213795 BRAFLDRAFT_219230 BRAFLDRAFT_278832
CIN: 
100181154 100181361 100186673(acox1)
SPU: 
578168 580036 580903 580963
DME: 
Dmel_CG17544 Dmel_CG4586 Dmel_CG5009 Dmel_CG9527 Dmel_CG9707(Acox57D-p) Dmel_CG9709(Acox57D-d)
DPO: 
Dpse_GA14550 Dpse_GA18591 Dpse_GA21857 Dpse_GA21980 Dpse_GA21981
DAN: 
Dana_GF11673 Dana_GF12814 Dana_GF12816 Dana_GF15197 Dana_GF15389 Dana_GF21407
DER: 
Dere_GG19624 Dere_GG21636 Dere_GG21822 Dere_GG22112 Dere_GG22113 Dere_GG23624
DPE: 
Dper_GL11770 Dper_GL11771 Dper_GL17222 Dper_GL21109 Dper_GL26258
DSE: 
Dsec_GM15834 Dsec_GM15835 Dsec_GM17014 Dsec_GM17495 Dsec_GM17941 Dsec_GM21823
DSI: 
Dsim_GD11316 Dsim_GD11593 Dsim_GD11595 Dsim_GD16824 Dsim_GD21764 Dsim_GD22578
DWI: 
Dwil_GK15355 Dwil_GK20899 Dwil_GK20900 Dwil_GK22892 Dwil_GK23839 Dwil_GK25030
DYA: 
Dyak_GE11899 Dyak_GE12194 Dyak_GE12195 Dyak_GE12655 Dyak_GE15692 Dyak_GE18444
DGR: 
Dgri_GH10984 Dgri_GH11897 Dgri_GH13470 Dgri_GH21827 Dgri_GH21832 Dgri_GH22025
DMO: 
Dmoj_GI15906 Dmoj_GI17222 Dmoj_GI17496 Dmoj_GI19074 Dmoj_GI19075 Dmoj_GI19114
DVI: 
Dvir_GJ15162 Dvir_GJ16816 Dvir_GJ17979 Dvir_GJ20048 Dvir_GJ20049 Dvir_GJ22244
AGA: 
AgaP_AGAP007958 AgaP_AGAP008016 AgaP_AGAP011798
AAG: 
AaeL_AAEL000370 AaeL_AAEL008574 AaeL_AAEL008841
CQU: 
CpipJ_CPIJ001556 CpipJ_CPIJ003870 CpipJ_CPIJ006187
AME: 
412020 552757
NVI: 
100115159(NV18937) 100119298(NV12399) 100122596(Acox3)
TCA: 
658001 660385 662475
API: 
100159207 100163509 100168090
PHU: 
Phum_PHUM320080 Phum_PHUM320090 Phum_PHUM617660
ISC: 
IscW_ISCW013214 IscW_ISCW017262
CEL: 
CELE_C48B4.1(C48B4.1) CELE_F08A8.1(acox-1) CELE_F08A8.3(F08A8.3) CELE_F08A8.4(F08A8.4) CELE_F58F9.7(F58F9.7) CELE_F59F4.1(F59F4.1)
CBR: 
CBG05491 CBG05550 CBG07943 CBG07946 CBG07947 CBG10043 CBG16008
BMY: 
Bm1_15615
NVE: 
NEMVE_v1g170851 NEMVE_v1g235541 NEMVE_v1g237514
HMG: 
100202148 100214840
TAD: 
TRIADDRAFT_18987 TRIADDRAFT_27680 TRIADDRAFT_28074 TRIADDRAFT_38001
AQU: 
100638349 100641682(Acox1)
ATH: 
AT1G06290(ACX3) AT1G06310(ACX6) AT2G35690(ACX5) AT3G51840(ACX4) AT4G16760(ACX1) AT5G65110(ACX2)
ALY: 
ARALYDRAFT_470649 ARALYDRAFT_485539(ACX4) ARALYDRAFT_493199 ARALYDRAFT_887833(ACX6) ARALYDRAFT_902679(ACX5) ARALYDRAFT_919837
GMX: 
100125585 100777033 100780811 100784451 100790627 100799226 100810829 547626(ACX1;2)
MTR: 
MTR_4g079290 MTR_4g100640 MTR_5g012920
CSV: 
101209181 101218159 101220632 101222521
RCU: 
RCOM_0186930 RCOM_0554440 RCOM_1119640
POP: 
POPTR_582787 POPTR_646132 POPTR_717426 POPTR_735866 POPTR_780712 POPTR_831370 POPTR_832274 POPTR_836303
VVI: 
100255430 100257352 100257386 100257524
OSA: 
4324062 4337904 4339846 4340972 4340976 4340986 4350881
DOSA: 
Os01t0159400-01(Os01g0159400) Os05t0163700-01(Os05g0163700) Os06t0103500-01(Os06g0103500) Os06t0346300-00(Os06g0346300) Os06t0347100-01(Os06g0347100) Os06t0354500-01(Os06g0354500) Os11t0605500-01(Os11g0605500)
BDI: 
100824216 100828594 100840647 100841774
SBI: 
SORBI_03g039670(SORBIDRAFT_03g039670) SORBI_06g001260(SORBIDRAFT_06g001260) SORBI_09g004830(SORBIDRAFT_09g004830) SORBI_10g004260(SORBIDRAFT_10g004260)
ZMA: 
100191469 100282107 100283936(cl716_1) 100285661 100382424
SMO: 
SELMODRAFT_100571 SELMODRAFT_122536 SELMODRAFT_134372 SELMODRAFT_178082 SELMODRAFT_187751 SELMODRAFT_442553 SELMODRAFT_90623
PPP: 
PHYPADRAFT_102649 PHYPADRAFT_186552 PHYPADRAFT_207164 PHYPADRAFT_217871 PHYPADRAFT_221246 PHYPADRAFT_231834
CRE: 
CHLREDRAFT_121379 CHLREDRAFT_122887 CHLREDRAFT_170822 CHLREDRAFT_40101
VCN: 
VOLCADRAFT_104659 VOLCADRAFT_58804 VOLCADRAFT_92640 VOLCADRAFT_93927 VOLCADRAFT_93964
OLU: 
OSTLU_13743
OTA: 
Ot01g02610
CME: 
CMK115C
SCE: 
YGL205W(POX1)
AGO: 
AGOS_AER358C
ERC: 
Ecym_1214
KLA: 
KLLA0F09933g
LTH: 
KLTH0G01914g
PPA: 
PAS_chr1-4_0538
VPO: 
Kpol_1035p54
ZRO: 
ZYRO0E08338g
CGR: 
CAGL0A03740g
NCS: 
NCAS_0E00630(NCAS0E00630)
NDI: 
NDAI_0I02880(NDAI0I02880)
TPF: 
TPHA_0A05790(TPHA0A05790)
TBL: 
TBLA_0I03240(TBLA0I03240)
TDL: 
TDEL_0D05820(TDEL0D05820)
KAF: 
KAFR_0F04110(KAFR0F04110)
DHA: 
DEHA2C01078g DEHA2D17248g
PIC: 
PICST_75424(POX1)
PGU: 
PGUG_00645 PGUG_00646 PGUG_01193
LEL: 
LELG_02916 LELG_02931
CAL: 
CaO19.13146(POX105) CaO19.1652(POX104) CaO19.5723(POX105) CaO19.9221(POX104)
CTP: 
CTRG_02374 CTRG_02377 CTRG_02721
CDU: 
CD36_64100 CD36_81790(POX2) CD36_81950(POX1)
COT: 
CORT_0C01430 CORT_0C01540
YLI: 
YALI0C23859g YALI0D24750g YALI0F10857g
CLU: 
CLUG_00156 CLUG_00696 CLUG_00697
FGR: 
FG02287.1
NHE: 
NECHADRAFT_62379
SSL: 
SS1G_10238
BFU: 
BC1G_08482
ANI: 
AN6752.2
NFI: 
NFIA_027340
AFM: 
AFUA_7G06090 AFUA_7G06100
AOR: 
AOR_1_844174(AO090005000479)
AFV: 
AFLA_077250 AFLA_115890
ACT: 
ACLA_007790 ACLA_094690
PCS: 
Pc20g01800
CIM: 
CIMG_01877 CIMG_07097
CPW: 
CPC735_034340 CPC735_046330
PBL: 
PAAG_03116 PAAG_07421
URE: 
UREG_01105 UREG_05801 UREG_06827
ABE: 
ARB_08051
TVE: 
TRV_04366
PNO: 
SNOG_05063 SNOG_05259
PTE: 
PTT_03254 PTT_10761
ZTR: 
MYCGRDRAFT_50735
TML: 
GSTUM_00008291001
CNE: 
CNG00320
CNB: 
CNBG4450
CGI: 
CGB_G6390W
PPL: 
POSPLDRAFT_25053
LBC: 
LACBIDRAFT_319093
MPR: 
MPER_03508
CCI: 
CC1G_15249
SCM: 
SCHCODRAFT_79089
UMA: 
UM01966.1 UM02208.1 UM04324.1
MGL: 
MGL_4209
PGR: 
PGTG_00655 PGTG_06197
MBR: 
MONBRDRAFT_29702
NGR: 
NAEGRDRAFT_44734 NAEGRDRAFT_79487
DDI: 
DDB_G0270990 DDB_G0286669 DDB_G0289993
DPP: 
DICPUDRAFT_158324 DICPUDRAFT_33780 DICPUDRAFT_97730
TGO: 
TGME49_047500
TET: 
TTHERM_00079730 TTHERM_00242260 TTHERM_00370760 TTHERM_00586710
PTM: 
GSPATT00008108001 GSPATT00009871001 GSPATT00012079001
PTI: 
PHATRDRAFT_19979(AOX1)
TPS: 
THAPSDRAFT_263878(AOX1_1)
PIF: 
PITG_05485 PITG_06755 PITG_10437 PITG_10443
PLU: 
plu2336
PAY: 
PAU_02326(aco)
XNE: 
XNC1_0653
PPW: 
PputW619_4651
PFS: 
PFLU3198
MXA: 
MXAN_6432
MFU: 
LILAB_14395
MSD: 
MYSTI_07028
CCX: 
COCOR_07019(mmgC3)
SUR: 
STAUR_7169
MPA: 
MAP2101
MAV: 
MAV_2078
MIT: 
OCO_20410
MIR: 
OCQ_19190
MIA: 
OCU_20510
MID: 
MIP_02874
MSM: 
MSMEG_4474
MSG: 
MSMEI_4364
MSA: 
Mycsm_04065
MUL: 
MUL_1233
MVA: 
Mvan_3808
MGI: 
Mflv_2726
MSP: 
Mspyr1_21640
MAB: 
MAB_3588
MMC: 
Mmcs_3435
MKM: 
Mkms_3498
MJL: 
Mjls_3446
MJD: 
JDM601_1578
MMI: 
MMAR_3631
MRH: 
MycrhN_4360
MMM: 
W7S_09570
MCB: 
Mycch_3333
MLI: 
MULP_03874
ASD: 
AS9A_0357
CJK: 
jk1941(acx)
CUR: 
cur_1845
CUA: 
CU7111_1778
CAR: 
cauri_2169(acx)
CRD: 
CRES_1991(acx)
CVA: 
CVAR_2774(acx)
NFA: 
nfa24790
NCY: 
NOCYR_2558 NOCYR_3821
NBR: 
O3I_017835 O3I_022680 O3I_024075 O3I_024515
RHA: 
RHA1_ro02047
RER: 
RER_16630
ROP: 
ROP_17180
REQ: 
REQ_37470
GBR: 
Gbro_1022
GPO: 
GPOL_c10560
GOR: 
KTR9_0919
TPR: 
Tpau_0678
SCO: 
SCO3247(SCE29.16c)
SGR: 
SGR_6404 SGR_6637
SSX: 
SACTE_0582
SVL: 
Strvi_0232
SCT: 
SCAT_p1214
SCY: 
SCATT_p05130
SFA: 
Sfla_5665 Sfla_5925
SHY: 
SHJG_1655
SHO: 
SHJGH_1419
SALB: 
XNR_2339 XNR_5735
STRP: 
F750_0645 F750_0933
KSK: 
KSE_12570 KSE_58080
LXX: 
Lxx21820(acx2)
CMI: 
CMM_0813
CMS: 
CMS_0070
CMC: 
CMN_00769
MTS: 
MTES_1132
ART: 
Arth_2142
AAU: 
AAur_2138
ACH: 
Achl_1889
AAI: 
AARI_16120(aco)
APN: 
Asphe3_18640
ARR: 
ARUE_c22940
RSA: 
RSal33209_2074
KRH: 
KRH_16780
MLU: 
Mlut_11700
BCV: 
Bcav_3568
BFA: 
Bfae_23500
JDE: 
Jden_2376
KSE: 
Ksed_21270
XCE: 
Xcel_3111
IVA: 
Isova_0336
SKE: 
Sked_34870
CFL: 
Cfla_2935
CFI: 
Celf_3192
CGA: 
Celgi_2729
NCA: 
Noca_0437
KFL: 
Kfla_6493
TFU: 
Tfu_2239
NDA: 
Ndas_3221
NAL: 
B005_0176
GOB: 
Gobs_0304
BSD: 
BLASA_0275
MMAR: 
MODMU_0321
KRA: 
Krad_4030
SEN: 
SACE_5537 SACE_7372
SVI: 
Svir_31740
AMD: 
AMED_8080
AMN: 
RAM_41510
AMM: 
AMES_7958
PDX: 
Psed_6176
SESP: 
BN6_30630
MAU: 
Micau_3812
MIL: 
ML5_4604
VMA: 
VAB18032_15120
AMS: 
AMIS_57460
ASE: 
ACPL_5569
CAI: 
Caci_3363
SRU: 
SRU_1701
SRM: 
SRM_01907(caiA)
CMR: 
Cycma_3937
BBD: 
Belba_3185
RSI: 
Runsl_2262
MTT: 
Ftrac_1371
FJO: 
Fjoh_3394
RBI: 
RB2501_03675
CAO: 
Celal_2067
ZGA: 
zobellia_2370(acxA)
MRS: 
Murru_1859
NDO: 
DDD_0071
 » show all
Taxonomy
Reference
1  [PMID:7462191]
  Authors
Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto T, Kikuchi T, Ando M, Okuda S.
  Title
Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase.
  Journal
J. Biochem. (Tokyo). 88 (1980) 1481-6.
  Organism
Rattus norvegicus [GN:rno], Candida lipolytica
Reference
2  [PMID:7400120]
  Authors
Osumi T, Hashimoto T, Ui N.
  Title
Purification and properties of acyl-CoA oxidase from rat liver.
  Journal
J. Biochem. (Tokyo). 87 (1980) 1735-46.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
61116-22-1
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