KEGG   ENZYME: 1.3.99.18Help
Entry
EC 1.3.99.18                Enzyme                                 

Name
quinaldate 4-oxidoreductase;
quinaldic acid 4-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)
Reaction(IUBMB)
quinaldate + acceptor + H2O = kynurenate + reduced acceptor [RN:R03687]
Reaction(KEGG)
Substrate
quinaldate [CPD:C06325];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
kynurenate [CPD:C01717];
reduced acceptor [CPD:C00030]
Comment
The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes. 2,4,6-Trinitrobenzene sulfonate, 1,4-benzoquinone, 1,2-naphthoquinone, nitroblue tetrazolium, thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride, phenazine methosulfate, 2,6-dichlorophenolindophenol and cytochrome c will act as electron acceptors for both.
History
EC 1.3.99.18 created 1999
Reference
1  [PMID:8292263]
  Authors
Sauter M, Tshisuaka B, Fetzner S, Lingens F.
  Title
Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases.
  Journal
Biol. Chem. Hoppe. Seyler. 374 (1993) 1037-46.
Reference
2  [PMID:8357532]
  Authors
Fetzner S, Lingens F.
  Title
Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1.
  Journal
Biol. Chem. Hoppe. Seyler. 374 (1993) 363-76.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149885-77-8

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