KEGG   ENZYME: 1.3.99.24Help
Entry
EC 1.3.99.24                Enzyme                                 

Name
2-amino-4-deoxychorismate dehydrogenase;
ADIC dehydrogenase;
2-amino-2-deoxyisochorismate dehydrogenase;
SgcG
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2 [RN:R09559]
Reaction(KEGG)
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
FMN [CPD:C00061]
Product
3-(1-carboxyvinyloxy)anthranilate [CPD:C19686];
FMNH2 [CPD:C01847]
Comment
The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].
History
EC 1.3.99.24 created 2008
Orthology
K20156  
2-amino-4-deoxychorismate dehydrogenase
Genes
SGB: 
Taxonomy
Reference
1  [PMID:18182490]
  Authors
Van Lanen SG, Lin S, Shen B.
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 494-9.
  Sequence
Reference
2
  Authors
Yu, L., Mah, S., Otani, T. and Dedon, P.
  Title
The benzoxazolinate of C-1027 confers intercalative DNA binding.
  Journal
J. Am. Chem. Soc. 117 (1995) 8877-8878.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system