KEGG   ENZYME: 1.3.99.30Help
Entry
EC 1.3.99.30                Enzyme                                 
Name
phytoene desaturase (3,4-didehydrolycopene-forming);
5-step phytoene desaturase;
five-step phytoene desaturase;
phytoene desaturase (ambiguous);
Al-1
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname
15-cis-phytoene:acceptor oxidoreductase (3,4-didehydrolycopene-forming)
Reaction(IUBMB)
15-cis-phytoene + 5 acceptor = all-trans-3,4-didehydrolycopene + 5 reduced acceptor (overall reaction) [RN:R09703];
(1a) 15-cis-phytoene + acceptor = all-trans-phytofluene + reduced acceptor [RN:R09692];
(1b) all-trans-phytofluene + acceptor = all-trans-zeta-carotene + reduced acceptor [RN:R04787];
(1c) all-trans-zeta-carotene + acceptor = all-trans-neurosporene + reduced acceptor [RN:R04798];
(1d) all-trans-neurosporene + acceptor = all-trans-lycopene + reduced acceptor [RN:R04800];
(1e) all-trans-lycopene + acceptor = all-trans-3,4-didehydrolycopene + reduced acceptor [RN:R07518]
Reaction(KEGG)
Substrate
15-cis-phytoene [CPD:C05421];
acceptor [CPD:C00028];
all-trans-phytofluene [CPD:C05414];
all-trans-zeta-carotene [CPD:C05430];
all-trans-neurosporene [CPD:C05431];
all-trans-lycopene [CPD:C05432]
Product
all-trans-3,4-didehydrolycopene [CPD:C15867];
reduced acceptor [CPD:C00030];
all-trans-phytofluene [CPD:C05414];
all-trans-zeta-carotene [CPD:C05430];
all-trans-neurosporene [CPD:C05431];
all-trans-lycopene [CPD:C05432]
Comment
This enzyme is involved in carotenoid biosynthesis and catalyses up to five desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]).
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K15745  
phytoene desaturase (3,4-didehydrolycopene-forming)
Genes
API: 
NCR: 
SMP: 
PAN: 
FGR: 
NHE: 
SSL: 
BFU: 
AOR: 
AOR_1_1270084(AO090020000158)
ANG: 
ANI_1_1482064(An07g01150)
AFV: 
AFLA_102520
ABE: 
ARB_03950
TVE: 
TRV_03238
PNO: 
SNOG_00342
PTE: 
PTT_09941
UMA: 
UM04210.1
 » show all
Taxonomy
Reference
1  [PMID:11017770]
  Authors
Hausmann A, Sandmann G.
  Title
A single five-step desaturase is involved in the carotenoid biosynthesis pathway to beta-carotene and torulene in Neurospora crassa.
  Journal
Fungal. Genet. Biol. 30 (2000) 147-53.
Reference
2  [PMID:18812228]
  Authors
Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S
  Title
Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation.
  Journal
Fungal. Genet. Biol. 45 (2008) 1497-505.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system