KEGG   ENZYME: 1.4.3.13Help
Entry
EC 1.4.3.13                 Enzyme                                 

Name
protein-lysine 6-oxidase;
lysyl oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
Reaction(IUBMB)
peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 [RN:R04239]
Reaction(KEGG)
Substrate
peptidyl-L-lysyl-peptide [CPD:C03530];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
peptidyl-allysyl-peptide [CPD:C03531];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5].
History
EC 1.4.3.13 created 1980, modified 1983
Orthology
K00277  
protein-lysine 6-oxidase
Genes
HSA: 
4015(LOX)
PTR: 
471614(LOX)
PPS: 
GGO: 
PON: 
MCC: 
699997(LOX)
MCF: 
MMU: 
16948(Lox)
RNO: 
24914(Lox)
HGL: 
TUP: 
CFA: 
481478(LOX)
FCA: 
PTG: 
BTA: 
280841(LOX)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
396474(LOX)
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
734204(lox)
XTR: 
780067(lox)
DRE: 
404621(lox)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
DME: 
DER: 
DSI: 
DYA: 
 » show all
Taxonomy
Reference
1  [PMID:4838158]
  Authors
Harris ED, Gonnerman WA, Savage JE, O'Dell BL.
  Title
Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.
  Journal
Biochim. Biophys. Acta. 341 (1974) 332-44.
  Organism
Gallus gallus
Reference
2  [PMID:33171]
  Authors
Rayton JK, Harris ED.
  Title
Induction of lysyl oxidase with copper. Properties of an in vitro system.
  Journal
J. Biol. Chem. 254 (1979) 621-6.
  Organism
Gallus gallus
Reference
3  [PMID:7318]
  Authors
Stassen FL.
  Title
Properties of highly purified lysyl oxidase from embryonic chick cartilage.
  Journal
Biochim. Biophys. Acta. 438 (1976) 49-60.
  Organism
Gallus gallus
Reference
4  [PMID:11779117]
  Authors
Palamakumbura AH, Trackman PC.
  Title
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
  Journal
Anal. Biochem. 300 (2002) 245-51.
  Organism
Bos taurus
Reference
5  [PMID:6147351]
  Authors
Kagan HM, Williams MA, Williamson PR, Anderson JM.
  Title
Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.
  Journal
J. Biol. Chem. 259 (1984) 11203-7.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99676-44-5

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