KEGG   ENZYME: 1.4.3.23Help
Entry
EC 1.4.3.23                 Enzyme                                 

Name
7-chloro-L-tryptophan oxidase;
RebO
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
7-chloro-L-tryptophan:oxygen oxidoreductase
Reaction(IUBMB)
7-chloro-L-tryptophan + O2 = 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2 [RN:R09560]
Reaction(KEGG)
Substrate
7-chloro-L-tryptophan [CPD:C19687];
O2 [CPD:C00007]
Product
2-imino-3-(7-chloroindol-3-yl)propanoate [CPD:C19688];
H2O2 [CPD:C00027]
Comment
Contains a noncovalently bound FAD [1,2]. This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide. The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan [1].
History
EC 1.4.3.23 created 2010
Reference
1  [PMID:15743957]
  Authors
Nishizawa T, Aldrich CC, Sherman DH
  Title
Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
J. Bacteriol. 187 (2005) 2084-92.
  Sequence
[up:Q8KHS0]
Reference
2  [PMID:16313168]
  Authors
Howard-Jones AR, Walsh CT
  Title
Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.
  Journal
Biochemistry. 44 (2005) 15652-63.
  Sequence
[up:Q8KHS0]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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