| Entry |
|
|---|
| Name |
monoamine oxidase;
adrenalin oxidase;
adrenaline oxidase;
amine oxidase (ambiguous);
amine oxidase (flavin-containing);
amine:oxygen oxidoreductase (deaminating) (flavin-containing);
epinephrine oxidase;
MAO;
MAO A;
MAO B;
MAO-A;
MAO-B;
monoamine oxidase A;
monoamine oxidase B;
monoamine:O2 oxidoreductase (deaminating);
polyamine oxidase (ambiguous);
serotonin deaminase;
spermidine oxidase (ambiguous);
spermine oxidase (ambiguous);
tyraminase;
tyramine oxidase
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
 |
|---|
| Sysname |
amine:oxygen oxidoreductase (deaminating)
|
|---|
| Reaction(IUBMB) |
RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN: R01853]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.
|
|---|
| Pathway |
| Glycine, serine and threonine metabolism | | Arginine and proline metabolism | | Histidine metabolism | | Tyrosine metabolism | | Phenylalanine metabolism | | Tryptophan metabolism | | Isoquinoline alkaloid biosynthesis | | Drug metabolism - cytochrome P450 | | Metabolic pathways | | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
|
|---|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | ISC: | | NVE: | | AQU: | | CRE: | | VCN: | | PAN: | | FGR: | | NHE: | | VAL: | | ANI: | | AFM: | | AOR: | | ANG: | | AFV: | | PCS: | | URE: | | PNO: | | ZTR: | | CNE: | | CNB: | | CGI: | | MBR: | | NGR: | | DDI: | | DPP: | | TET: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOM: | | XOR: | | XCI: | | PSD: | | VFM: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PEN: | | PSA: | | PSZ: | | PSR: | | PBA: | | PDR: | | AVN: | | AVL: | | AVD: | | PAR: | | PCR: | | PRW: | | PAT: | | PSM: | | GAG: | | GNI: | | GPS: | | PIN: | | TTU: | | MMT: | | AFI: | | SAGA: | | RPI: | | RPF: | | REU: | | REH: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCT: | | BXE: | | BPT: | | PNA: | | VEI: | | CTT: | | LCH: | | AZO: | | BBA: | | BBAT: | | DOL: | | DAL: | | DAT: | | DTO: | | MXA: | | MSD: | | CCX: | | SUR: | | SCL: | | HOH: | | MMN: | | MLO: | | MCI: | | MOP: | | MAM: | | PLA: | | SME: | | ARA: | | AVI: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | AOL: | | XAU: | | AZC: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | BID: | | MSL: | | HMC: | | MSC: | | CCR: | | CCS: | | CAK: | | CSE: | | BSB: | | RDE: | | RLI: | | KVU: | | KVL: | | OAR: | | MMR: | | SJP: | | SCH: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | RCE: | | AZL: | | PBR: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BPF: | | BJS: | | GTN: | | GTH: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | EAT: | | EAN: | | BBE: | | PJD: | | GYM: | | PMW: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBF: | | CBM: | | CBJ: | | CBE: | | CPY: | | CCE: | | CSH: | | CCB: | | CLB: | | CCL: | | CAD: | | CSR: | | SGY: | | TOC: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | TPR: | | SCB: | | SCT: | | SCY: | | SHY: | | SHO: | | SVE: | | SALB: | | KSK: | | MTS: | | KRH: | | XCE: | | IVA: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | PACH: | | PFR: | | PPC: | | PBO: | | PRA: | | MPH: | | NCA: | | NAL: | | TCU: | | SRO: | | KRA: | | SEN: | | AMD: | | AMN: | | AMM: | | SESP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | CAI: | | SNA: | | CWO: | | PUV: | | LBI: | | LBF: | | TPX: | | ACM: | | TSA: | | TRS: | | SRU: | | SRM: | | CPI: | | SCN: | | HHY: | | DFE: | | SLI: | | EOL: | | FAE: | | GFO: | | FJO: | | FBC: | | CAO: | | KDI: | | LAN: | | ZGA: | | PTQ: | | NDO: | | OTE: | | PLM: | | SACI: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYC: | | SYF: | | SYD: | | SYX: | | MAR: | | CYP: | | CYN: | | CYH: | | CGC: | | CAN: | | GLP: | | CMP: | | NPU: | | CALT: | | RIV: | | TER: | | GEI: | | ONI: | | CTHE: | | PLP: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | DRA: | | DGE: | | DDR: | | DPT: | | DPD: | | TRA: | | NMG: | | NGE: | | NOU: | | HAH: | |
» show all
 |
|---|
| Reference |
1 |
|---|
| Authors |
Blaschko, H. |
|---|
| Title |
Amine oxidase. |
|---|
| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 337-351. |
|---|
| Reference |
|
|---|
| Authors |
Dostert PL, Strolin Benedetti M, Tipton KF. |
|---|
| Title |
Interactions of monoamine oxidase with substrates and inhibitors. |
|---|
| Journal |
Med. Res. Rev. 9 (1989) 45-89. |
|---|
| Reference |
|
|---|
| Authors |
Edmondson DE, Mattevi A, Binda C, Li M, Hubalek F. |
|---|
| Title |
Structure and mechanism of monoamine oxidase. |
|---|
| Journal |
Curr. Med. Chem. 11 (2004) 1983-93. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Shih JC, Chen K. |
|---|
| Title |
Regulation of MAO-A and MAO-B gene expression. |
|---|
| Journal |
Curr. Med. Chem. 11 (2004) 1995-2005. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J. |
|---|
| Title |
Monoamine oxidases: certainties and uncertainties. |
|---|
| Journal |
Curr. Med. Chem. 11 (2004) 1965-82. |
|---|
| Reference |
|
|---|
| Authors |
De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A. |
|---|
| Title |
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. |
|---|
| Journal |
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 12684-9. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Youdim MB, Edmondson D, Tipton KF. |
|---|
| Title |
The therapeutic potential of monoamine oxidase inhibitors. |
|---|
| Journal |
Nat. Rev. Neurosci. 7 (2006) 295-309. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Youdim MB, Bakhle YS. |
|---|
| Title |
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness. |
|---|
| Journal |
Br. J. Pharmacol. 147 Suppl 1 (2006) S287-96. |
|---|
| Organism |
|
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9001-66-5 |
|---|
