| Entry |
|
| Name |
pyridoxal 5'-phosphate synthase;
pyridoxamine 5'-phosphate oxidase;
pyridoxamine phosphate oxidase;
pyridoxine (pyridoxamine)phosphate oxidase;
pyridoxine (pyridoxamine) 5'-phosphate oxidase;
pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating);
PMP oxidase;
pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) (incorrect);
pyridoxamine-phosphate oxidase;
PdxH
|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
 |
| Sysname |
pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
|
| Reaction(IUBMB) |
(1) pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2 [RN: R00277];
(2) pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2 [RN: R00278]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
A flavoprotein (FMN). In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). N4'-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine.
|
| Pathway |
| Vitamin B6 metabolism | | Metabolic pathways |
|
| Orthology |
| pyridoxamine 5'-phosphate oxidase |
|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | TCA: | | PHU: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | MGL: | | PGR: | | NGR: | | DDI: | | DPP: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | WBR: | | WGL: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | BFL: | | BPN: | | BVA: | | BCHR: | | HDE: | | DDA: | | DDC: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | SECT: | | SEHC: | | EBF: | | HIN: | | HIT: | | HIP: | | HIQ: | | HIF: | | HIL: | | HIU: | | HIE: | | HIZ: | | HDU: | | HPR: | | MSU: | | MHT: | | MHQ: | | MHX: | | APL: | | APJ: | | APA: | | ASU: | | ASI: | | AAP: | | AAT: | | AAO: | | AAN: | | BTO: | | XFA: | | XFT: | | XFM: | | XFN: | | XFF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | CJA: | | AVN: | | AVL: | | AVD: | | PAR: | | PCR: | | PRW: | | ACI: | | ACD: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | MCT: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | ILO: | | CPS: | | PHA: | | PAT: | | PSM: | | SDE: | | MAQ: | | MHC: | | MAD: | | MBS: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | GPS: | | PIN: | | PSY: | | TTU: | | FBL: | | CBU: | | CBS: | | CBD: | | CBG: | | CBC: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | LLO: | | TCX: | | TCY: | | MEC: | | ALV: | | TVI: | | TMB: | | AEH: | | HHA: | | TKM: | | TNI: | | HNA: | | HCH: | | CSA: | | HEL: | | ABO: | | ADI: | | MMW: | | MME: | | MPC: | | TOL: | | AHA: | | ASA: | | AVR: | | TAU: | | OCE: | | DNO: | | AFE: | | AFR: | | ACU: | | AFI: | | BCI: | | SAGA: | | RMA: | | VOK: | | GPB: | | NMA: | | NME: | | NMP: | | NMH: | | NMC: | | NMN: | | NMT: | | NMI: | | NMD: | | NMM: | | NMS: | | NMQ: | | NMW: | | NMZ: | | NGO: | | NGK: | | NGT: | | NLA: | | CVI: | | LHK: | | PSE: | | RSO: | | RSC: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BRH: | | BGD: | | BYI: | | BUK: | | BPX: | | PNU: | | PNE: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | TEQ: | | TEA: | | TEG: | | TAS: | | TAT: | | PUT: | | AKA: | | RFR: | | POL: | | PNA: | | AAV: | | AJS: | | DIA: | | AAA: | | ACK: | | VEI: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | ADN: | | ADK: | | RTA: | | MPT: | | HAR: | | MMS: | | HSE: | | CFU: | | LCH: | | TIN: | | THI: | | RGE: | | TMZ: | | APP: | | KCI: | | KCT: | | KBL: | | KBT: | | KDE: | | KGA: | | KON: | | BPRC: | | ABU: | | ABT: | | ANT: | | ARC: | | BBA: | | BBAT: | | BEX: | | BMX: | | DPR: | | DSF: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | HOH: | | WOL: | | WOO: | | WRI: | | WPI: | | WEN: | | WED: | | AMA: | | AMF: | | ACN: | | APH: | | ERU: | | ERW: | | ERG: | | ECN: | | ECH: | | NSE: | | NRI: | | PUB: | | PEL: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | LAS: | | LAA: | | LSO: | | LCC: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMB: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | AOL: | | BHE: | | BQU: | | BQR: | | BBK: | | BTR: | | BGR: | | BCD: | | BAUS: | | BVN: | | XAU: | | AZC: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | BID: | | MSL: | | HDN: | | HMC: | | RVA: | | PHL: | | MSC: | | CCR: | | CCS: | | CAK: | | CSE: | | PZU: | | BSB: | | AEX: | | SIL: | | SIT: | | RSP: | | RSH: | | RSQ: | | RSK: | | RCP: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | KVU: | | KVL: | | PSF: | | PGA: | | PGL: | | OAT: | | OAR: | | MMR: | | HNE: | | HBA: | | ZMO: | | ZMN: | | ZMM: | | ZMB: | | ZMP: | | NAR: | | NPP: | | SAL: | | SWI: | | SPHM: | | SJP: | | SCH: | | SSY: | | ELI: | | GOX: | | GOH: | | GBE: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | RRU: | | RRF: | | RCE: | | MAG: | | AZL: | | ALI: | | ABS: | | TMO: | | THAL: | | PBR: | | APB: | | PGV: | | MAI: | | MAN: | | APC: | | APM: | | BSUB: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CVA: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | CMI: | | CMS: | | CMC: | | MTS: | | ART: | | ACH: | | APN: | | RSA: | | BCV: | | BFA: | | KSE: | | IVA: | | SKE: | | CFL: | | ICA: | | PPC: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | NML: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | RXY: | | CWO: | | AYM: | | PUV: | | SNG: | | SSM: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | TPX: | | ACM: | | BTH: | | BFR: | | BFS: | | BFG: | | BXY: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | PPN: | | SRU: | | SRM: | | RMR: | | RMG: | | CPI: | | NKO: | | PHE: | | PSN: | | SHG: | | SCN: | | HHY: | | SGN: | | CMR: | | BBD: | | EVI: | | CHU: | | DFE: | | SLI: | | LBY: | | RSI: | | FLI: | | EOL: | | FAE: | | MTT: | | GFO: | | FJO: | | FPS: | | FBR: | | FCO: | | FIN: | | COC: | | CCM: | | RBI: | | ZPR: | | CAT: | | RAN: | | RAI: | | RAR: | | RAG: | | RAE: | | FBC: | | CAO: | | CLY: | | WVI: | | KDI: | | LAN: | | ZGA: | | MRS: | | ASL: | | ORH: | | PTQ: | | NDO: | | POM: | | FBA: | | BBL: | | BPI: | | BMM: | | BCP: | | BBG: | | BBQ: | | BLP: | | FTE: | | OHO: | | IPO: | | OTE: | | CAA: | | MIN: | | AMU: | | GAU: | | RBA: | | IPA: | | SACI: | | PHM: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYX: | | SYP: | | SYNE: | | TEL: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CGC: | | CAN: | | CSN: | | DSL: | | HAO: | | GLP: | | CYU: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMT: | | PMF: | | LEP: | | GEI: | | CEP: | | MIC: | | CTHE: | | PLP: | | SCS: | | CTS: | | IAL: | | RRS: | | RCA: | | CAG: | | TRO: | | STI: | | CAP: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | TRA: | | MRB: | | MRE: | | MSV: | | MHD: | | TTR: | | » show all
 |
| Reference |
|
| Authors |
Choi JD, Bowers-Komro M, Davis MD, Edmondson DE, McCormick DB. |
| Title |
Kinetic properties of pyridoxamine (pyridoxine)-5'-phosphate oxidase from rabbit liver. |
| Journal |
J. Biol. Chem. 258 (1983) 840-5. |
| Organism |
Oryctolagus cuniculus |
| Reference |
|
| Authors |
WADA H, SNELL EE. |
| Title |
The enzymatic oxidation of pyridoxine and pyridoxamine phosphates. |
| Journal |
J. Biol. Chem. 236 (1961) 2089-95. |
| Organism |
Oryctolagus cuniculus |
| Reference |
|
| Authors |
Notheis C, Drewke C, Leistner E. |
| Title |
Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli. |
| Journal |
Biochim. Biophys. Acta. 1247 (1995) 265-71. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS. |
| Title |
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. |
| Journal |
FEBS. Lett. 449 (1999) 45-8. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Musayev FN, Di Salvo ML, Ko TP, Schirch V, Safo MK. |
| Title |
Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase. |
| Journal |
Protein. Sci. 12 (2003) 1455-63. |
| Organism |
|
| Reference |
|
| Authors |
Safo MK, Musayev FN, Schirch V. |
| Title |
Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme. |
| Journal |
Acta. Crystallogr. D. Biol. Crystallogr. 61 (2005) 599-604. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Zhang Z, McCormick DB |
| Title |
Uptake and metabolism of N-(4'-pyridoxyl)amines by isolated rat liver cells. |
| Journal |
Arch. Biochem. Biophys. 294 (1992) 394-7. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9029-21-4 |