KEGG   ENZYME: 1.5.1.10Help
Entry
EC 1.5.1.10                 Enzyme                                 
Name
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway
Lysine biosynthesis
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00293  
saccharopine dehydrogenase (NADP+, L-glutamate forming)
Genes
SCE: 
YNR050C(LYS9)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05670(NCAS0A05670)
NDI: 
NDAI_0K02690(NDAI0K02690)
TPF: 
TPHA_0M02120(TPHA0M02120)
TBL: 
TBLA_0F00190(TBLA0F00190)
TDL: 
TDEL_0A07910(TDEL0A07910)
KAF: 
KAFR_0C04810(KAFR0C04810)
DHA: 
DEHA2F17424g
PIC: 
PICST_70210(LYS9)
PGU: 
PGUG_04239
LEL: 
LELG_02987
CAL: 
CaO19.7448(LYS9)
CTP: 
CTRG_05710
CDU: 
CD36_86570
COT: 
CORT_0C00740
YLI: 
YALI0D22891g
CLU: 
CLUG_04206
NCR: 
NCU03748
SMP: 
SMAC_02595
PAN: 
PODANSg8147
TTT: 
THITE_2107047
MTM: 
MYCTH_2300877
MGR: 
MGG_17041
FGR: 
FG00346.1
NHE: 
NECHADRAFT_101578
VAL: 
VDBG_04207
SSL: 
SS1G_13213
BFU: 
BC1G_15049
ANI: 
AN5601.2
NFI: 
NFIA_105250
AFM: 
AFUA_4G11340
AOR: 
AOR_1_1934154(AO090003001086)
ANG: 
ANI_1_878184(An04g05260)
AFV: 
AFLA_027350
ACT: 
ACLA_050430
PCS: 
Pc22g05800(Lys7)
CIM: 
CIMG_01555
CPW: 
CPC735_049050
PBL: 
PAAG_02693
URE: 
UREG_05275
ABE: 
ARB_02329
TVE: 
TRV_04693
AJE: 
HCAG_01575
PNO: 
SNOG_09324
PTE: 
PTT_10655
ZTR: 
MYCGRDRAFT_110462(LYS9)
TML: 
GSTUM_00000988001
SPO: 
SPBC3B8.03
NGR: 
NAEGRDRAFT_56327
DDI: 
DDB_G0285267(sdh)
DPP: 
DICPUDRAFT_86861
KKO: 
Kkor_1620
SIT: 
TM1040_0106
PGA: 
PGA1_c32700
PGL: 
PGA2_c30970
MTT: 
Ftrac_3732
TLI: 
Tlie_0256
 » show all
Taxonomy
Reference
1  [PMID:4380448]
  Authors
Jones EE, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
  Journal
J. Biol. Chem. 241 (1966) 3430-4.
  Organism
Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-55-0
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