KEGG   ENZYME: 1.5.1.10Help
Entry
EC 1.5.1.10                 Enzyme                                 

Name
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.10 created 1972, modified 2011
Pathway
Lysine biosynthesis
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00293  
saccharopine dehydrogenase (NADP+, L-glutamate forming)
Genes
SBI: 
SORBI_03g030510(SORBIDRAFT_03g030510)
SCE: 
YNR050C(LYS9)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05670(NCAS0A05670)
NDI: 
NDAI_0K02690(NDAI0K02690)
TPF: 
TPHA_0M02120(TPHA0M02120)
TBL: 
TBLA_0F00190(TBLA0F00190)
TDL: 
TDEL_0A07910(TDEL0A07910)
KAF: 
KAFR_0C04810(KAFR0C04810)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_1934154(AO090003001086) AOR_1_408164(AO090001000233)
ANG: 
ANI_1_3268014(An01g13590) ANI_1_878184(An04g05260)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
ACAN: 
PTM: 
NGR: 
KKO: 
SIT: 
PGA: 
PGL: 
PGD: 
LMD: 
RED: 
TLI: 
DOI: 
MTT: 
 » show all
Taxonomy
Reference
1  [PMID:4380448]
  Authors
Jones EE, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
  Journal
J. Biol. Chem. 241 (1966) 3430-4.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-55-0

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