KEGG   ENZYME: 1.5.1.30Help
Entry
EC 1.5.1.30                 Enzyme                                 

Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Show
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
Riboflavin metabolism
Orthology
K05901  
biliverdin reductase / flavin reductase
Genes
HSA: 
645(BLVRB)
PTR: 
456039(BLVRB)
PPS: 
100989093(BLVRB)
GGO: 
101142015(BLVRB)
PON: 
100446184(BLVRB)
NLE: 
100587172(BLVRB)
MCC: 
703020(BLVRB)
MCF: 
102142962(BLVRB)
CSAB: 
103234707(BLVRB)
RRO: 
104676113(BLVRB)
CJC: 
100391206(BLVRB)
SBQ: 
101043206(BLVRB)
MMU: 
233016(Blvrb)
RNO: 
292737(Blvrb)
CGE: 
100768929(Blvrb)
NGI: 
103750766(Blvrb)
HGL: 
101697384(Blvrb)
OCU: 
100340115(BLVRB)
TUP: 
102490802(BLVRB)
CFA: 
476456(BLVRB)
AML: 
100467254(BLVRB)
UMR: 
103661047(BLVRB)
FCA: 
101092315(BLVRB)
PTG: 
102957700(BLVRB)
BTA: 
281650(BLVRB)
BOM: 
102277747(BLVRB)
CHX: 
102187796(BLVRB)
OAS: 
101119750(BLVRB)
SSC: 
100625219(BLVRB)
CFR: 
102522968(BLVRB)
BACU: 
103014515(BLVRB)
LVE: 
103082225(BLVRB)
ECB: 
100068145(BLVRB)
MYB: 
102251416(BLVRB)
MYD: 
102759928(BLVRB)
PALE: 
102879551(BLVRB)
LAV: 
100665167(BLVRB)
MDO: 
100017892(BLVRB)
SHR: 
100930351(BLVRB)
OAA: 
100073853(BLVRB)
GGA: 
396352(P22)
MGP: 
PHI: 
102113532(BLVRB)
AAM: 
106493723(BLVRB)
ASN: 
102387963(BLVRB)
AMJ: 
102574563(BLVRB)
ACS: 
100564796(blvrb)
PBI: 
103053858(BLVRB)
GJA: 
107107369(BLVRB)
XLA: 
443881(blvrb.L)
XTR: 
100124834(blvrb)
DRE: 
436959(blvrb)
TRU: 
101061122(blvrb)
TNG: 
MZE: 
101484658(blvrb)
OLA: 
101163919(blvrb)
XMA: 
102228591(blvrb)
SASA: 
106580739(blvrb) 106612705(BLVRB)
LCM: 
102358034(BLVRB)
CMK: 
103173572(blvrb)
CIN: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20759(Dsim_GD20759)
DWI: 
DYA: 
Dyak_GE24730(Dyak_CG9471)
DGR: 
DMO: 
DVI: 
MDE: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
 » show all
Taxonomy
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem. Int. 15 (1987) 1-8.
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem. J. 345 Pt 2 (2000) 393-9.
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56626-29-0

DBGET integrated database retrieval system