KEGG   ENZYME: 1.5.3.5Help
Entry
EC 1.5.3.5                  Enzyme                                 

Name
(S)-6-hydroxynicotine oxidase;
L-6-hydroxynicotine oxidase;
6-hydroxy-L-nicotine oxidase;
6-hydroxy-L-nicotine:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
(S)-6-hydroxynicotine:oxygen oxidoreductase
Reaction(IUBMB)
(S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 [RN:R03202]
Reaction(KEGG)
Substrate
(S)-6-hydroxynicotine [CPD:C01056];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD:C01297];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD).
History
EC 1.5.3.5 created 1972
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Reference
1  [PMID:5646150]
  Authors
Dai VD, Decker K, Sund H.
  Title
Purification and properties of L-6-hydroxynicotine oxidase.
  Journal
Eur. J. Biochem. 4 (1968) 95-102.
  Organism
Arthrobacter oxidans
Reference
2  [PMID:5849820]
  Authors
Decker K, Bleeg H.
  Title
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans.
  Journal
Biochim. Biophys. Acta. 105 (1965) 313-24.
  Organism
Arthrobacter oxidans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-29-4

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