KEGG   ENZYME: 1.6.3.4Help
Entry
EC 1.6.3.4                  Enzyme                                 

Name
NADH oxidase (H2O-forming);
H2O-forming NADH oxidase;
Nox-2
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
NADH:oxygen oxidoreductase (H2O-forming)
Reaction(IUBMB)
2 NADH + 2 H+ + O2 = 2 NAD+ + 2 H2O [RN:R10517]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1].
History
EC 1.6.3.4 created 2013
Orthology
K17869  
NADH oxidase (H2O-forming)
Genes
LCA: 
LPI: 
LPQ: 
LCB: 
LCZ: 
LCS: 
LCE: 
LCW: 
LCL: 
LCX: 
LRH: 
LRG: 
LRL: 
LRA: 
LRO: 
LRC: 
 » show all
Taxonomy
Reference
1  [PMID:3082630]
  Authors
Schmidt HL, Stocklein W, Danzer J, Kirch P, Limbach B
  Title
Isolation and properties of an H2O-forming NADH oxidase from Streptococcus faecalis.
  Journal
Eur. J. Biochem. 156 (1986) 149-55.
Reference
2  [PMID:8254304]
  Authors
Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y
  Title
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans.
  Journal
J. Gen. Microbiol. 139 (1993) 2343-51.
  Sequence
[smu:SMU_1117]
Reference
3  [PMID:8824824]
  Authors
Matsumoto J, Higuchi M, Shimada M, Yamamoto Y, Kamio Y
  Title
Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans.
  Journal
Biosci. Biotechnol. Biochem. 60 (1996) 39-43.
  Sequence
[smu:SMU_1117]
Reference
4  [PMID:15014929]
  Authors
Kawasaki S, Ishikura J, Chiba D, Nishino T, Niimura Y
  Title
Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria.
  Journal
Arch. Microbiol. 181 (2004) 324-30.
Reference
5  [PMID:22418266]
  Authors
Zhang YW, Tiwari MK, Gao H, Dhiman SS, Jeya M, Lee JK
  Title
Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus.
  Journal
Enzyme. Microb. Technol. 50 (2012) 255-62.
  Sequence
[lrg:LRHM_0312]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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