KEGG   ENZYME: 1.6.99.1Help
Entry
EC 1.6.99.1                 Enzyme                                 
Name
NADPH dehydrogenase;
NADPH2 diaphorase;
NADPH diaphorase;
OYE;
diaphorase;
dihydronicotinamide adenine dinucleotide phosphate dehydrogenase;
NADPH-dehydrogenase;
NADPH-diaphorase;
NADPH2-dehydrogenase;
old yellow enzyme;
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase;
TPNH dehydrogenase;
TPNH-diaphorase;
triphosphopyridine diaphorase;
triphosphopyridine nucleotide diaphorase;
NADPH2 dehydrogenase;
NADPH:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With other acceptors
BRITE hierarchy
Sysname
NADPH:acceptor oxidoreductase
Reaction(IUBMB)
NADPH + H+ + acceptor = NADP+ + reduced acceptor [RN:R00282]
Reaction(KEGG)
Substrate
NADPH [CPD:C00005];
H+ [CPD:C00080];
acceptor [CPD:C00028]
Product
NADP+ [CPD:C00006];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FMN in yeast, FAD in plants).
Orthology
K00354  
NADPH2 dehydrogenase
Genes
SCE: 
YHR179W(OYE2) YPL171C(OYE3)
AGO: 
KLA: 
CGR: 
PIC: 
PICST_31957(OYE2.9) PICST_31958(OYE2.4) PICST_43720(OYE2.2) PICST_52325(OYE3.3) PICST_57042(OPR1) PICST_89722(OYE2.1)
CAL: 
CaO19.10947(OYE22) CaO19.125(EBP1) CaO19.3443(OYE22)
YLI: 
SPO: 
CNE: 
TET: 
PHA: 
PSHAa0880
BUR: 
Bcep18194_A4953 Bcep18194_B0492 Bcep18194_B0951 Bcep18194_B1736
HAR: 
HEAR2541
CFF: 
CFF8240_0619
BRA: 
BRADO0620(namA)
BBT: 
BBta_7562(namA)
NPH: 
NP5226A
 » show all
Taxonomy
Reference
1
  Authors
Akesson, A., Ehrenberg, A. and Theorell, H.
  Title
Old yellow enzyme.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 477-494.
Reference
2  [PMID:13471057]
  Authors
AVRON M, JAGENDORF AT.
  Title
Some further investigations on chloroplast TPNH diaphorase.
  Journal
Arch. Biochem. Biophys. 72 (1957) 17-24.
  Organism
Spinacia oleracea
Reference
3
  Authors
Jagendorf, A.T.
  Title
Chloroplast TPNH diaphorase.
  Journal
Methods Enzymol. 6 (1963) 430-434.
Reference
4
  Authors
Theorell, H.
  Title
Das gelbe Oxydationsferment.
  Journal
Biochem. Z. 278 (1935) 263-290.
Reference
5  [PMID:13373435]
  Authors
AKESON A, THEORELL H.
  Title
Molecular weight and FMN content of crystallin old yellow enzyme.
  Journal
Arch. Biochem. Biophys. 65 (1956) 439-48.
  Organism
Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9001-68-7
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