KEGG   ENZYME: 1.7.2.4Help
Entry
EC 1.7.2.4                  Enzyme                                 
Name
nitrous-oxide reductase;
nitrous oxide reductase;
N2O reductase;
nitrogen:(acceptor) oxidoreductase (N2O-forming)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
nitrogen:cytochrome c oxidoreductase (N2O-forming)
Reaction(IUBMB)
nitrogen + H2O + 2 ferricytochrome c = nitrous oxide + 2 ferrocytochrome c + 2 H+ [RN:R02804]
Reaction(KEGG)
Substrate
nitrogen [CPD:C00697];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitrous oxide [CPD:C00887];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The reaction is observed only in the direction of nitrous oxide reduction. Contains the mixed-valent dinuclear CuA species at the electron entry site of the enzyme, and the tetranuclear Cu-Z centre in the active site.
In Paracoccus pantotrophus, the electron donor is cytochrome c552.
Pathway
Nitrogen metabolism
Microbial metabolism in diverse environments
Orthology
K00376  
nitrous-oxide reductase
Genes
RHD: 
PPR: 
PAE: 
PA3392(nosZ)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PFE: 
PSF113_2997(nosZ)
PMK: 
MDS_0139
PSA: 
PST_3550(nosZ)
PSZ: 
PSTAB_3522(nosZ)
PSR: 
PSTAA_3647(nosZ)
PSC: 
A458_03705
PSJ: 
PSJM300_03110
PSH: 
Psest_0793
PBA: 
PSEBR_a2099 PSEBR_a2644
PDR: 
H681_24785
SDN: 
Sden_2219
SLO: 
Shew_3400
CPS: 
CPS_4732(nosZ)
MAQ: 
Maqu_3078
MHC: 
MARHY3020(nosZ)
MBS: 
MRBBS_3129(nosZ)
PIN: 
Ping_1428
AEH: 
Mlg_1074
TGR: 
Tgr7_2564
TNI: 
TVNIR_1638(nosZ_[H])
HCH: 
HCH_03388
ADI: 
B5T_04283(nosZ)
GPB: 
HDN1F_37580(nosZ)
NGK: 
NGK_1651 NGK_1652
NGT: 
NGTW08_1299
NLA: 
NLA_16550
PSE: 
NH8B_3640(nosZ)
RSO: 
RSp1368(nosZ)
RPI: 
Rpic_4059
RPF: 
Rpic12D_4171
REH: 
PHG252(nosZ)
RME: 
Rmet_4917(nosZ)
BMA: 
BMA0995(nosZ)
BPS: 
BPSL1607(nosZ)
BPM: 
BURPS1710b_2255(nosZ)
BPL: 
BURPS1106A_2115(nosZ)
BPD: 
BURPS668_2060(nosZ)
BPR: 
GBP346_A2185(nosZ)
BPZ: 
BP1026B_I1546(nosZ)
BPQ: 
BPC006_I2161
BTE: 
BTH_I2325
BPT: 
Bpet4339(nosZ)
AXY: 
AXYL_04548(nosZ)
RFR: 
Rfer_3199
AJS: 
Ajs_1139
DIA: 
Dtpsy_1060
ADN: 
Alide_3077
ADK: 
Alide2_1370
LCH: 
Lcho_1483
RGE: 
RGE_19210(nosZ)
EBA: 
ebA6272(nosZ)
AZO: 
azo3113(nosZ)
AZA: 
AZKH_2415(nosZ)
DAR: 
Daro_1571 Daro_1575
TMZ: 
Tmz1t_0664
DSU: 
Dsui_0882 Dsui_3309
TBD: 
Tbd_1389
APP: 
CAP2UW1_3419
WSU: 
WS0914(NOSZ) WS0916(NOSZ)
TDN: 
Suden_1298 Suden_1770
SUA: 
Saut_1988
CFF: 
CFF8240_0440
CCV: 
CCV52592_0010
CCO: 
CCC13826_1729
NSA: 
Nitsa_0495
NIS: 
NIS_1789
SUN: 
SUN_2179
ADE: 
Adeh_2402
ACP: 
A2cp1_1556
AFW: 
Anae109_0244
ANK: 
AnaeK_1461
DTI: 
Desti_0657
SME: 
SMa1182(nosZ)
SMQ: 
SinmeB_6148
SMI: 
BN406_04364(nosZ)
SMEG: 
C770_GR4pC0751
SMEL: 
SM2011_a1182(nosZ)
SFD: 
USDA257_c39060(nosZ)
BME: 
BMEII0973 BMEII0974
BMZ: 
BM28_B0268 BM28_B0269(nosZ)
BMG: 
BM590_B0267 BM590_B0268
BMW: 
BMNI_II0261 BMNI_II0262
BMF: 
BAB2_0928(nosZ)
BMB: 
BruAb2_0905(nosZ)
BMC: 
BAbS19_II08570
BAA: 
BAA13334_II01657
BMS: 
BRA0275(nosZ)
BSI: 
BS1330_II0272(nosZ)
BMT: 
BSUIS_B0281
BSV: 
BSVBI22_B0271(nosZ)
BOV: 
BOV_A0251(nosZ)
BCS: 
BCAN_B0277(nosZ)
BSK: 
BCA52141_II0802
BMR: 
BMI_II270(nosZ)
BPP: 
BPI_II273(nosZ)
OAN: 
Oant_4346
BJA: 
blr0315(nosZ)
BBT: 
BBta_6008(nosZ)
RPA: 
RPA2061(nosZ)
RPB: 
RPB_3142
RPC: 
RPC_0428
RPE: 
RPE_3095
RPT: 
Rpal_2351
RPX: 
Rpdx1_3443
OCA: 
OCAR_5030(nosZ)
OCG: 
OCA5_c29290(nosZ)
AOL: 
S58_64860(nosZ)
MET: 
M446_2861
HDN: 
Hden_1882
SIL: 
SPOA0050(nosZ)
RSQ: 
Rsph17025_3319
RSK: 
RSKD131_4445
RCP: 
RCAP_rcp00075(nosZ)
RDE: 
RD1_1547(nosZ)
RLI: 
RLO149_c031550(nosZ)
PDE: 
Pden_4219
DSH: 
Dshi_3194(nosZ)
PSF: 
PSE_3128(nosZ)
RCE: 
RC1_3912(nosZ)
MAG: 
amb3086
ALI: 
AZOLI_p20731(nosZ)
ABS: 
AZOBR_p340004(nosZ)
PGV: 
SL003B_0564(nosZ)
GTN: 
GTNG_1734(nosZ)
DSY: 
DSY0261
DHD: 
Dhaf_0209
DDH: 
Desde_0186
DDL: 
Desdi_0167
DRU: 
Desru_1528
DMI: 
Desmer_3457
LBI: 
LEPBI_I0383
LBF: 
LBF_0371(nosZ)
PDN: 
HMPREF9137_0507
SRU: 
SRU_0308(nosZ)
SRM: 
SRM_00384(nosZ)
RMR: 
Rmar_2012
RMG: 
Rhom172_0852
NKO: 
Niako_5286
PSN: 
Pedsa_3647
SCN: 
Solca_1787
HHY: 
Halhy_5487
BBD: 
Belba_1979
DFE: 
Dfer_0693
RSI: 
Runsl_0111
MTT: 
Ftrac_2708
GFO: 
GFO_1411(nosZ)
FCO: 
FCOL_10605
RBI: 
RB2501_05465
RAN: 
Riean_1674
RAI: 
RA0C_1969
RAR: 
RIA_0512
RAG: 
B739_0187
RAE: 
G148_1913
FBC: 
FB2170_03800
CAO: 
Celal_3154
ZGA: 
zobellia_2236(nosZ)
MRS: 
Murru_2821
ASL: 
Aeqsu_0143
PTQ: 
P700755_000691
FBA: 
FIC_02107
OHO: 
Oweho_3463
OTE: 
Oter_1803
GAU: 
GAU_1385(nosZ)
IAL: 
IALB_0848(nosZ)
TRO: 
trd_A0194
STI: 
Sthe_0735
CAP: 
CLDAP_07150
HTH: 
HTH_0163(nosZ)
HTE: 
Hydth_0164
PMX: 
PERMA_1257
DAP: 
Dacet_0941
FPL: 
Ferp_0128
HMA: 
rrnAC0390(nosZ)
HHI: 
HAH_1235(nosZ)
HLA: 
Hlac_1165
HME: 
HFX_5091(nosZ)
HBO: 
Hbor_30430
HXA: 
Halxa_1765
NOU: 
Natoc_4169
PCL: 
Pcal_1928
PYR: 
P186_0746
HAH: 
Halar_1529
 » show all
Taxonomy
Reference
1  [PMID:3000778]
  Authors
Coyle CL, Zumft WG, Kroneck PM, Korner H, Jakob W.
  Title
Nitrous oxide reductase from denitrifying Pseudomonas perfectomarina. Purification and properties of a novel multicopper enzyme.
  Journal
Eur. J. Biochem. 153 (1985) 459-67.
Reference
2  [PMID:17027372]
  Authors
Zumft WG, Kroneck PM
  Title
Respiratory transformation of nitrous oxide (N2O) to dinitrogen by Bacteria and Archaea.
  Journal
Adv. Microb. Physiol. 52 (2007) 107-227.
Reference
3  [PMID:20422435]
  Authors
Dell'Acqua S, Pauleta SR, Paes de Sousa PM, Monzani E, Casella L, Moura JJ, Moura I
  Title
A new CuZ active form in the catalytic reduction of N(2)O by nitrous oxide reductase from Pseudomonas nautica.
  Journal
J. Biol. Inorg. Chem. 15 (2010) 967-76.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
55576-44-8
DBGET integrated database retrieval system