protein-S-isoprenylcysteine O-methyltransferase;
farnesyl cysteine C-terminal methyltransferase;
farnesyl-protein carboxymethyltransferase;
protein C-terminal farnesylcysteine O-methyltransferase;
farnesylated protein C-terminal O-methyltransferase;
isoprenylated protein methyltransferase;
prenylated protein methyltransferase;
protein S-farnesylcysteine C-terminal methyltransferase;
S-farnesylcysteine methyltransferase;
prenylcysteine carboxylmethyltransferase [misleading];
prenylcysteine carboxymethyltransferase [misleading];
prenylcysteine methyltransferase

Transferases;
Transferring one-carbon groups;
Methyltransferases

S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester [RN:R04496]

R04496

S-adenosyl-L-methionine [CPD:C00019];
protein C-terminal S-farnesyl-L-cysteine [CPD:C04506]

C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.

1  [PMID:3290900]

Clarke S, Vogel JP, Deschenes RJ, Stock J.

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 4643-7.

Tremella brasiliensis, Tremella mesenterica

2  [PMID:2753892]

Ota IM, Clarke S.

Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues.

J. Biol. Chem. 264 (1989) 12879-84.

Saccharomyces cerevisiae [GN:sce], Tremella brasiliensis, Tremella mesenterica

3  [PMID:2398053]

Stephenson RC, Clarke S.

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

J. Biol. Chem. 265 (1990) 16248-54.

Rattus norvegicus [GN:rno]