KEGG   ENZYME: 2.1.1.122Help
Entry
EC 2.1.1.122                Enzyme                                 

Name
(S)-tetrahydroprotoberberine N-methyltransferase;
tetrahydroprotoberberine cis-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [RN:R04716]
Reaction(KEGG)
R04716;
(other) R04691 R08789
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05204]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05318]
Comment
Involved in the biosynthesis of isoquinoline alkaloids in plants.
History
EC 2.1.1.122 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13396  
(S)-tetrahydroprotoberberine N-methyltransferase
Reference
1
  Authors
Rueffer, M., Zumstein, G., Zenk, M.H.
  Title
Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis.
  Journal
Phytochemistry 29 (1990) 3727-3733.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
106878-42-6

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