| Entry |
|
|---|
| Name |
(RS)-norcoclaurine 6-O-methyltransferase |
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + (RS)-norcoclaurine =
S-adenosyl-L-homocysteine + (RS)-coclaurine [RN:R05162] |
|---|
| Reaction(KEGG) |
R05162 > R05123;
(other) R04715 R05214 R08793
 |
|---|
| Substrate |
S-adenosyl-L-methionine [CPD:C00019];
(R,S)-norcoclaurine [CPD:C06346] |
|---|
| Product |
S-adenosyl-L-homocysteine [CPD:C00021];
(R,S)-coclaurine [CPD:C06348] |
|---|
| Comment |
The enzyme will also catalyse the 6-O-methylation of
(RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this
alkaloid has not been found to occur in plants. |
|---|
| Pathway |
ec00950 Isoquinoline alkaloid biosynthesis
ec01100 Metabolic pathways
ec01110 Biosynthesis of secondary metabolites |
|---|
| Orthology |
K13383 (RS)-norcoclaurine 6-O-methyltransferase |
|---|
Reference
Authors
Title
Journal
|
1
Rueffer, M., Nagakura, N., Zenk, M.H.
Partial purification and properties of
S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransfera
se from Argemone platyceras cell cultures.
Planta Med. 49 (1983) 131-137. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7925429]
Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y.
Purification and characterization of S-adenosyl-L-methionine:
norcoclaurine 6-O-methyltransferase from cultured Coptis japonica
cells.
Eur. J. Biochem. 225 (1994) 125-31.
Coptis japonica |
|---|
Reference
Authors
Title
Journal
|
3
Stadler, R., Zenk, M.H.
A revision of the generally accepted pathway for the biosynthesis of
the benzyltetrahydroisoquinoline reticuline.
Liebigs Ann. Chem. (1990) 555-562. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.1.1.128
IUBMB Enzyme Nomenclature: 2.1.1.128
ExPASy - ENZYME nomenclature database: 2.1.1.128
BRENDA, the Enzyme Database: 2.1.1.128
CAS: 89700-33-4 |
|---|
