| Entry |
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| Name |
(RS)-norcoclaurine 6-O-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine [RN: R05162]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
(R,S)-norcoclaurine [CPD: C06346]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
(R,S)-coclaurine [CPD: C06348]
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| Comment |
The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
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| Pathway |
| Isoquinoline alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
| (RS)-norcoclaurine 6-O-methyltransferase |
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| Reference |
1 |
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| Authors |
Rueffer, M., Nagakura, N., Zenk, M.H. |
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| Title |
Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures. |
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| Journal |
Planta Med. 49 (1983) 131-137. |
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| Reference |
|
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| Authors |
Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y. |
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| Title |
Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. |
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| Journal |
Eur. J. Biochem. 225 (1994) 125-31. |
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| Organism |
Coptis japonica |
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| Reference |
3 |
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| Authors |
Stadler, R., Zenk, M.H. |
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| Title |
A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline. |
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| Journal |
Liebigs Ann. Chem. (1990) 555-562. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 89700-33-4 |
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