KEGG   ENZYME: 2.1.1.128Help
Entry
EC 2.1.1.128                Enzyme                                 

Name
(RS)-norcoclaurine 6-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine [RN:R05162]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(R,S)-norcoclaurine [CPD:C06346]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(R,S)-coclaurine [CPD:C06348]
Comment
The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
History
EC 2.1.1.128 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13383  
(RS)-norcoclaurine 6-O-methyltransferase
Reference
1
  Authors
Rueffer, M., Nagakura, N., Zenk, M.H.
  Title
Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures.
  Journal
Planta Med. 49 (1983) 131-137.
Reference
2  [PMID:7925429]
  Authors
Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y.
  Title
Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells.
  Journal
Eur. J. Biochem. 225 (1994) 125-31.
  Organism
Coptis japonica
  Sequence
[up:Q9LEL6]
Reference
3
  Authors
Stadler, R., Zenk, M.H.
  Title
A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline.
  Journal
Liebigs Ann. Chem. (1990) 555-562.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
89700-33-4

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