KEGG   ENZYME: 2.1.1.128Help
Entry
EC 2.1.1.128                Enzyme                                 

Name
(RS)-norcoclaurine 6-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine [RN:R05162]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(R,S)-norcoclaurine [CPD:C06346]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(R,S)-coclaurine [CPD:C06348]
Comment
The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
History
EC 2.1.1.128 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13383  (RS)-norcoclaurine 6-O-methyltransferase
Reference
1
  Authors
Rueffer, M., Nagakura, N., Zenk, M.H.
  Title
Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures.
  Journal
Planta Med. 49 (1983) 131-137.
Reference
2  [PMID:7925429]
  Authors
Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y.
  Title
Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells.
  Journal
Eur. J. Biochem. 225 (1994) 125-31.
  Sequence
Reference
3
  Authors
Stadler, R., Zenk, M.H.
  Title
A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline.
  Journal
Liebigs Ann. Chem. (1990) 555-562.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.128
IUBMB Enzyme Nomenclature: 2.1.1.128
ExPASy - ENZYME nomenclature database: 2.1.1.128
BRENDA, the Enzyme Database: 2.1.1.128
CAS: 89700-33-4

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