KEGG   ENZYME: 2.1.1.137Help
Entry
EC 2.1.1.137                Enzyme                                 

Name
arsenite methyltransferase;
S-adenosyl-L-methionine:arsenic(III) methyltransferase;
S-adenosyl-L-methionine:methylarsonite As-methyltransferase;
methylarsonite methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:arsenite As-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate [RN:R05755];
(2) S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate [RN:R05756]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
arsenite [CPD:C06697];
methylarsonite [CPD:C07295]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylarsonate [CPD:C07294];
dimethylarsinate [CPD:C07308]
Comment
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by EC 1.20.4.2, methylarsonate reductase, to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate for this enzyme (EC 2.1.1.137), which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
History
EC 2.1.1.137 created 2000, (EC 2.1.1.138 incorporated 2003), modified 2003
Orthology
K07755  
arsenite methyltransferase
Genes
HSA: 
57412(AS3MT)
PTR: 
450703(AS3MT)
PPS: 
100990214(AS3MT)
GGO: 
101153169(AS3MT)
PON: 
100450997(AS3MT)
NLE: 
100599978(AS3MT)
MCC: 
714122(AS3MT)
MCF: 
102134286(AS3MT)
CJC: 
100396953(AS3MT)
MMU: 
57344(As3mt)
RNO: 
140925(As3mt)
CGE: 
100758973(As3mt)
TUP: 
102472983(AS3MT)
CFA: 
486865(AS3MT)
AML: 
100477280(AS3MT)
UMR: 
103681866(AS3MT)
FCA: 
101085409(AS3MT)
PTG: 
102967021(AS3MT)
BTA: 
505482(AS3MT) 788389(AS3MT)
BOM: 
102269963(AS3MT)
PHD: 
102327712(AS3MT)
CHX: 
100861071(AS3MT)
OAS: 
101115498(AS3MT)
SSC: 
100622012(AS3MT)
CFR: 
102508617(AS3MT)
BACU: 
103007103(AS3MT)
LVE: 
103071271(AS3MT)
ECB: 
100069819(AS3MT)
PALE: 
102884356(AS3MT)
OAA: 
100080992(AS3MT)
GGA: 
423870(AS3MT)
MGP: 
TGU: 
100231410(AS3MT)
FAB: 
101821864(AS3MT)
PHI: 
102102307(AS3MT)
FPG: 
101921972(AS3MT)
FCH: 
102054327(AS3MT)
CLV: 
102088931(AS3MT)
ASN: 
102372717(AS3MT)
AMJ: 
102570140(AS3MT)
PSS: 
102462506(AS3MT)
CMY: 
102946003(AS3MT)
ACS: 
100559124(as3mt)
XTR: 
DRE: 
664699(as3mt)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
LGI: 
NVE: 
AQU: 
AFM: 
 » show all
Taxonomy
Reference
1  [PMID:10604879]
  Authors
Zakharyan RA, Aposhian HV.
  Title
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
  Journal
Chem. Res. Toxicol. 12 (1999) 1278-83.
Reference
2  [PMID:10387927]
  Authors
Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.
  Journal
Toxicol. Appl. Pharmacol. 158 (1999) 9-15.
Reference
3  [PMID:8806872]
  Authors
Zakharyan RA, Wildfang E, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic.
  Journal
Toxicol. Appl. Pharmacol. 140 (1996) 77-84.
Reference
4  [PMID:8605285]
  Authors
Zakharyan R, Wu Y, Bogdan GM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.
  Journal
Chem. Res. Toxicol. 8 (1995) 1029-38.
Reference
5  [PMID:11790780]
  Authors
Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ.
  Title
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.
  Journal
J. Biol. Chem. 277 (2002) 10795-803.
  Sequence
[rno:140925]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
167140-41-2

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