KEGG   ENZYME: 2.1.1.148Help
Entry
EC 2.1.1.148                Enzyme                                 
Name
thymidylate synthase (FAD);
Thy1;
ThyX
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+ [RN:R06613]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
dUMP [CPD:C00365];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
dTMP [CPD:C00364];
tetrahydrofolate [CPD:C00101];
NADP+ [CPD:C00006]
Comment
Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.
Pathway
Pyrimidine metabolism
One carbon pool by folate
Orthology
K03465  
thymidylate synthase (FAD)
Genes
DDI: 
DPP: 
PLF: 
VVM: 
GNI: 
GNIT_1810(thyX)
MMT: 
AFE: 
AFR: 
AFE_0732(thyX)
ACU: 
AFI: 
HPY: 
HP1533(thyX)
HEO: 
C694_07940(thyX)
HPJ: 
jhp1421(thyX)
HPA: 
HPAG1_1383(thyX)
HPS: 
HPSH_07875(thyX)
HHP: 
HPSH112_07735(thyX)
HHQ: 
HPSH169_07545(thyX)
HHR: 
HPSH417_07460(thyX)
HPG: 
HPG27_1454(thyX)
HPP: 
HPP12_1507(thyX)
HPB: 
HELPY_1504(thyX)
HPL: 
HPB8_1709(thyX)
HPC: 
HPPC_07505(thyX)
HCA: 
HPPC18_06950(thyX)
HPM: 
HPSJM_07820(thyX)
HPE: 
HPELS_07885(thyX)
HPO: 
HMPREF4655_20125(thyX)
HPI: 
hp908_1519(thyX)
HPQ: 
hp2017_1462(thyX)
HPW: 
hp2018_1467(thyX)
HPU: 
HPCU_07700(thyX)
HEF: 
HPF16_1427(thyX)
HPF: 
HPF30_1404(thyX)
HEQ: 
HPF32_1418(thyX)
HEX: 
HPF57_1445(thyX)
HPT: 
HPSAT_07370(thyX)
HPZ: 
HPKB_1434(thyX)
HPV: 
HPV225_1486(thyX)
HPX: 
HMPREF0462_1530(thyX)
HEN: 
HPSNT_07590(thyX)
HPH: 
HPLT_07625(thyX)
HEG: 
HPGAM_08080(thyX)
HPN: 
HPIN_07455(thyX)
HEP: 
HPPN120_07520(thyX)
HEU: 
HPPN135_07730(thyX)
HES: 
HPSA_07320(thyX)
HCN: 
HPB14_07370(thyX)
HPD: 
KHP_1384
HER: 
C695_07960(thyX)
HEI: 
C730_07945(thyX)
HPYA: 
HPAKL117_07360(thyX)
HPYK: 
HPAKL86_00215(thyX)
HPYO: 
HPOK113_1447(thyX)
HPYL: 
HPOK310_1415(thyX)
HHE: 
HH1120(thyX)
HAC: 
Hac_1786(thyX)
HMS: 
HMU13850(thyX)
HFE: 
HFELIS_01720(thyX)
HBI: 
HBZC1_16490
HCE: 
HCW_01300(thyX)
HCM: 
HCD_04640(thyX)
HCP: 
HCN_2087(thyX)
HCB: 
HCBAA847_2360(thyX)
WSU: 
WS2228(thyX)
TDN: 
Suden_0017
SUA: 
Saut_0012
SKU: 
Sulku_0112
SULR: 
B649_00490
CJE: 
Cj0026c(thyX)
CJB: 
BN148_0026c(thyX)
CJJ: 
CJJ81176_0053(thyX)
CJU: 
C8J_0025(thyX)
CJN: 
ICDCCJ_22
CJI: 
CJSA_0026(thyX)
CJM: 
CJM1_0024(thyX)
CJS: 
CJS3_0026(thyX)
CJP: 
A911_00125(thyX)
CJR: 
CJE0026(thyX)
CJD: 
JJD26997_0028(thyX)
CFF: 
CFF8240_1800(thyX)
CCV: 
CCV52592_2063(thyX)
CHA: 
CHAB381_1762(thyX)
CCO: 
CCC13826_1861(thyX)
CLA: 
Cla_0011(thyX)
ABU: 
Abu_2330(thyX)
ABT: 
ABED_2154
ARC: 
ABLL_2840
SDL: 
Sdel_0001
SBA: 
Sulba_2564
NSA: 
Nitsa_2118
NIS: 
NIS_1855(thyX)
SUN: 
SUN_2288
GSU: 
GSU3106(thyX)
GSK: 
KN400_3045(thyX)
GME: 
Gmet_0378(thyX)
GUR: 
Gura_4063(thyX)
GLO: 
Glov_1027(thyX)
GBM: 
Gbem_3711(thyX)
GEO: 
Geob_0683(thyX)
GEM: 
GM21_3806(thyX)
GEB: 
GM18_4159
PCA: 
Pcar_2693(thyX)
PPD: 
Ppro_2649(thyX)
DVU: 
DVU2254(thyX)
DVL: 
Dvul_0990(thyX)
DVM: 
DvMF_3206(thyX)
DVG: 
Deval_2098
DDE: 
Dde_2321
DDS: 
Ddes_0584
DDN: 
DND132_3470
DMA: 
DMR_30810(thyX)
DSA: 
Desal_3189(thyX)
DAS: 
Daes_2190
DAF: 
Desaf_0003
DHY: 
DESAM_21281(thyX)
DPI: 
BN4_20531(thyX)
LIP: 
LI1188(thyX)
LIR: 
LAW_01225(thyX)
DBA: 
Dbac_3494
DRT: 
Dret_1744
DPS: 
DP2228
DAK: 
DaAHT2_0838
DPR: 
Despr_2817
DSF: 
UWK_02359
DAT: 
HRM2_18050(thyX)
ADE: 
Adeh_1139
ACP: 
A2cp1_1268
AFW: 
Anae109_1187
ANK: 
AnaeK_1199
DBR: 
Deba_1514
HMR: 
Hipma_0811
RPR: 
RP301(thyX)
RPO: 
MA1_01460(thyX)
RPW: 
M9W_01465(thyX)
RPZ: 
MA3_01480(thyX)
RPG: 
MA5_02830(thyX)
RPS: 
M9Y_01470(thyX)
RPV: 
MA7_01460(thyX)
RPQ: 
rpr22_CDS295(thyX)
RPL: 
H375_3130
RPN: 
H374_7790
RTY: 
RT0292(thyX)
RTT: 
RTTH1527_01420(thyX)
RTB: 
RTB9991CWPP_01425(thyX)
RCM: 
A1E_04060(thyX)
RCC: 
RCA_03710(thyX)
RBE: 
RBE_0275(thyX)
RBO: 
A1I_06415(thyX)
RCO: 
RC0405(thyX)
RFE: 
RF_0491(thyX)
RAK: 
A1C_02260(thyX)
RRI: 
A1G_02310(thyX)
RRJ: 
RrIowa_0486(thyX)
RRA: 
RPO_02290(thyX)
RRC: 
RPL_02280(thyX)
RRH: 
RPM_02270(thyX)
RRB: 
RPN_04620(thyX)
RRN: 
RPJ_02270(thyX)
RRP: 
RPK_04170(thyX)
RMS: 
RMA_0415(thyX)
RMI: 
RMB_06055(thyX)
RPK: 
RPR_04355(thyX)
RAF: 
RAF_ORF0379(thyX)
RHE: 
Rh054_02320(thyX)
RJA: 
RJP_0321(thyX)
RSV: 
Rsl_479(thyX)
RSW: 
MC3_02320(thyX)
RPH: 
RSA_02235(thyX)
RAU: 
MC5_05880(thyX)
RMO: 
MCI_06210(thyX)
RPP: 
MC1_02280(thyX)
RRE: 
MCC_02865(thyX)
RAM: 
MCE_02830(thyX)
OTS: 
OTBS_0340(thyX)
OTT: 
OTT_1076(thyX)
WOL: 
WD1198(thyX)
WBM: 
Wbm0741(thyX)
WOO: 
wOo_03250
WRI: 
WRi_011720(thyX)
WPI: 
WPa_0761(thyX)
WEN: 
wHa_10000(thyX)
WED: 
wNo_04220(thyX)
AMA: 
AM170(thyX)
AMF: 
AMF_127(thyX)
ACN: 
ACIS_01106(thyX)
APH: 
APH_0163(thyX)
ERU: 
Erum6790(thyX)
ERW: 
ERWE_CDS_07140(thyX)
ERG: 
ERGA_CDS_07060(thyX)
ECN: 
Ecaj_0686(thyX)
ECH: 
ECH_0317(thyX)
NSE: 
NSE_0163(thyX)
NRI: 
NRI_0159(thyX)
PUB: 
SAR11_0010(thyX)
PEL: 
SAR11G3_00010
MMN: 
midi_00610
RLT: 
Rleg2_4942(thyX)
AZC: 
AZC_2577(thyX) AZC_3595
BID: 
Bind_0769(thyX)
SIL: 
SPO1273(thyX)
RCP: 
RCAP_rcc03041(thyX)
JAN: 
Jann_1091(thyX)
PDE: 
Pden_0934(thyX)
DSH: 
Dshi_0768(thyX)
KVU: 
EIO_0175(thyX)
KVL: 
KVU_1514(thyX)
OAT: 
OAN307_c15820
OAR: 
OA238_c06750(thyX)
GOX: 
GOX1427(thyX)
GOH: 
B932_1676
GBE: 
GbCGDNIH1_1809(thyX)
ACR: 
Acry_0045(thyX)
AMV: 
ACMV_00690(thyX)
GDI: 
GDI_0868(thyX)
GDJ: 
Gdia_1151(thyX)
GXY: 
GLX_20430(thyX)
APT: 
APA01_24920(thyX)
APW: 
APA42C_24920
APF: 
APA03_24920
APU: 
APA07_24920
APG: 
APA12_24920
APQ: 
APA22_24920
APX: 
APA26_24920
APZ: 
APA32_24920
RRU: 
Rru_A2792(thyX)
RRF: 
F11_14325
RPM: 
RSPPHO_01621
AZL: 
AZL_019310(thy1)
ALI: 
AZOLI_1878(thyX)
ABS: 
AZOBR_100091(thyX)
TMO: 
TMO_2448(thyX)
APB: 
SAR116_0386
APC: 
HIMB59_00008610
APM: 
HIMB5_00010310
MGM: 
Mmc1_0404
DIN: 
Selin_2317
BSUB: 
BEST7613_1858(thyX)
BAO: 
BAMF_0917(thyX)
BAH: 
BAMEG_0822
BAI: 
BAA_3835
BAX: 
H9401_3626
BCZ: 
BCZK3445(thyX)
BWE: 
BcerKBAB4_3449
MCL: 
MCCL_plsB0052
CPE: 
CPE2425(thyX)
CPF: 
CPF_2735(thyX)
CPR: 
CPR_2421(thyX)
CTC: 
CTC02620(thyX)
CNO: 
NT01CX_1095(thyX)
CBO: 
CBO3500(thyX)
CBA: 
CLB_3559(thyX)
CBH: 
CLC_3448(thyX)
CBY: 
CLM_3970(thyX)
CBL: 
CLK_2946(thyX)
CBB: 
CLD_1002(thyX)
CBI: 
CLJ_B3811(thyX)
CBN: 
CbC4_0208(thyX)
CBF: 
CLI_3686(thyX)
CBM: 
CBF_3672(thyX)
CBJ: 
H04402_03603
CKL: 
CKL_2204(thyX)
CKR: 
CKR_1938
CCL: 
Clocl_3035
CAD: 
Curi_c22850(thyX)
CPAS: 
Clopa_4535
CDF: 
CD630_00540(thyX)
CDL: 
CDR20291_0047
CDG: 
CDBI1_00310
CST: 
CLOST_2223(thyX)
AMT: 
Amet_4498(thyX)
AOE: 
Clos_0472(thyX)
SWO: 
Swol_2353
SLP: 
Slip_2257
DSY: 
DSY0449(thyX)
DHD: 
Dhaf_0400(thyX)
DDH: 
Desde_0403
DDL: 
Desdi_0413
DRM: 
Dred_0195(thyX) Dred_1200
DAE: 
Dtox_1882 Dtox_3898
DCA: 
Desca_0189
DRU: 
Desru_0277
PTH: 
PTH_0298(thyX)
DAU: 
Daud_0189(thyX)
TJR: 
TherJR_0272
SGY: 
Sgly_0494
DOR: 
Desor_0227
DAI: 
Desaci_0471
DMI: 
Desmer_0226
FMA: 
FMG_0416(thyX)
APR: 
Apre_0772
EEL: 
EUBELI_10035
ERT: 
EUR_29810
ELM: 
ELI_3381
AWO: 
Awo_c11000(thyX)
CLE: 
Clole_0609
RIX: 
RO1_14650
RIM: 
ROI_22860
CCT: 
CC1_26290
EHA: 
Ethha_1474
RAL: 
Rumal_1959
RBR: 
RBR_09150
RCH: 
RUM_17150 RUM_20700
FPR: 
FP2_05300
FPA: 
FPR_29960
CHY: 
CHY_2336(thyX)
TEP: 
TepRe1_2170
TAE: 
TEPIRE1_24930 TEPIRE1_24940
MTA: 
Moth_2482
ADG: 
Adeg_0404
TPZ: 
Tph_c04940(thyX)
CSC: 
Csac_1367
ATE: 
Athe_2044(thyX)
COB: 
COB47_1814
CHD: 
Calhy_0712
COW: 
Calow_1730
CKI: 
Calkr_0521
CKN: 
Calkro_0613
CLC: 
Calla_1833
TOC: 
Toce_2112
CPO: 
COPRO5265_0833(thyX)
TNR: 
Thena_1526
MAS: 
Mahau_2175
NTH: 
Nther_0173
HOR: 
Hore_00980
HAS: 
Halsa_1940
HPK: 
Hprae_1706
AAR: 
Acear_0143
HHL: 
Halha_0168
SSG: 
Selsp_0785
SRI: 
SELR_07700(thyX)
MHG: 
MHY_11790
AFN: 
Acfer_0723
AIN: 
Acin_0961(thyX)
EUC: 
EC1_04720
MTU: 
Rv2754c(thyX)
MTV: 
RVBD_2754c
MTC: 
MT2824(thyX)
MRA: 
MRA_2779(thyX)
MTF: 
TBFG_12767(thyX)
MTB: 
TBMG_01221(thyX)
MTK: 
TBSG_01231
MTZ: 
TBXG_001211
MTG: 
MRGA327_16890(thyX)
MTI: 
MRGA423_17100(thyX)
MTE: 
CCDC5079_2528
MTL: 
CCDC5180_2498
MTO: 
MTCTRI2_2807(thyX)
MTD: 
UDA_2754c(thyX)
MTN: 
ERDMAN_3019(thyX)
MTJ: 
J112_14755(thyX)
MTUB: 
MT7199_2787
MBO: 
Mb2775c(thyX)
MBB: 
BCG_2770c(thyX)
MBT: 
JTY_2764(thyX)
MBM: 
BCGMEX_2763c(thyX)
MBK: 
K60_028480
MAF: 
MAF_27590(thyX)
MCE: 
MCAN_27811(thyX)
MCQ: 
BN44_60214(thyX)
MCV: 
BN43_40438(thyX)
MCX: 
BN42_40733(thyX)
MCZ: 
BN45_51138(thyX)
MLE: 
ML1514(thyX)
MLB: 
MLBr_01514(thyX)
MPA: 
MAP2865c(thyX)
MAV: 
MAV_3645(thyX)
MIT: 
OCO_34730
MIR: 
OCQ_35950
MIA: 
OCU_34780
MID: 
MIP_05230
MSM: 
MSMEG_2683(thyX)
MSG: 
MSMEI_2618(thyX)
MSA: 
Mycsm_02516
MUL: 
MUL_2183(thyX)
MVA: 
Mvan_2386(thyX)
MGI: 
Mflv_4001(thyX)
MSP: 
Mspyr1_33460
MAB: 
MAB_3085c(thyX)
MMC: 
Mmcs_2115(thyX)
MKM: 
Mkms_2161(thyX)
MJL: 
Mjls_2102(thyX)
MJD: 
JDM601_2504(thyX)
MMI: 
MMAR_1961(thyX)
MRH: 
MycrhN_5633
MMM: 
W7S_17375(thyX)
MCB: 
Mycch_2084
MLI: 
MULP_02127(thyX)
ASD: 
AS9A_1646
CGL: 
NCgl1897(thyX)
CGB: 
cg2162(thyX)
CGU: 
WA5_1897(ThyX)
CGT: 
cgR_1801(thyX)
CEF: 
CE1865(thyX)
CDI: 
DIP1465(thyX)
CDP: 
CD241_1411
CDH: 
CDB402_1375
CDT: 
CDHC01_1410
CDE: 
CDHC02_1363(thyX2)
CDR: 
CDHC03_1386(thyX2)
CDA: 
CDHC04_1386(thyX2)
CDZ: 
CD31A_1483(thyX2)
CDB: 
CDBH8_1459
CDS: 
CDC7B_1468(thyX2)
CDD: 
CDCE8392_1384(thyX2)
CDW: 
CDPW8_1456
CDV: 
CDVA01_1348(thyX2)
CJK: 
jk1130(thyX)
CUR: 
cur_0861(thyX)
CUA: 
CU7111_0847
CAR: 
cauri_1516(thyX)
CKP: 
ckrop_1125(thyX)
CPU: 
cpfrc_01269(thyX)
CPL: 
Cp3995_1298(thyX)
CPG: 
Cp316_1317(thyX)
CPP: 
CpP54B96_1288(thyX)
CPK: 
Cp1002_1264(thyX)
CPQ: 
CpC231_1263(thyX)
CPX: 
CpI19_1270(thyX)
CPZ: 
CpPAT10_1262(thyX)
COR: 
Cp267_1322(thyX)
COP: 
Cp31_1281(thyX)
COD: 
Cp106_1245(thyX)
COS: 
Cp4202_1255(thyX)
COI: 
CpCIP5297_1288(thyX)
COE: 
Cp258_1285(thyX)
COU: 
Cp162_1264(thyX)
CRD: 
CRES_1224(thyX)
CUL: 
CULC22_01375(thyX)
CUC: 
CULC809_01362(thyX)
CUE: 
CULC0102_1492(thyX)
CVA: 
CVAR_1631(thyX2)
CHN: 
A605_08550(thyX)
CCN: 
H924_08280(thyX)
RHA: 
RHA1_ro06746(thyX)
RER: 
RER_27310(thyX)
ROP: 
ROP_67320(thyX)
REQ: 
REQ_19410(thyX)
GBR: 
Gbro_2189
GPO: 
GPOL_c20830(thyX)
GOR: 
KTR9_2106
SCO: 
SCO5743(thyX)
SMA: 
SAV_2517(thyX)
SGR: 
SGR_1777(thyX)
SCB: 
SCAB_25201
SSX: 
SACTE_4914
SVL: 
Strvi_2077
SCT: 
SCAT_4515(thyX)
SCY: 
SCATT_45100
SFA: 
Sfla_1607
SBH: 
SBI_03362(thyX)
SHY: 
SHJG_6830
SHO: 
SHJGH_6590
SVE: 
SVEN_5392
SDV: 
BN159_2705(thyX)
SALB: 
XNR_1124
STRP: 
F750_5251(thyX)
SFI: 
SFUL_5660
KSK: 
KSE_53330(thyX)
TWH: 
TWT616(thyX)
TWS: 
TW633(thyX)
CMI: 
CMM_2037(thyX)
CMS: 
CMS_1197(thyX)
CMC: 
CMN_01998(thyX)
TFU: 
Tfu_1387
NDA: 
Ndas_1441
NAL: 
B005_4072(thyX)
TCU: 
Tcur_2472
FRA: 
Francci3_3547(thyX)
FRE: 
Franean1_1195(thyX)
FRI: 
FraEuI1c_1115
FAL: 
FRAAL5743(thyX)
FSY: 
FsymDg_3627
ACE: 
Acel_1504(thyX)
NML: 
Namu_2236(thyX)
BSD: 
BLASA_3705(thyX)
MMAR: 
MODMU_4342(thyX)
SEN: 
SACE_5902(thyX)
SVI: 
Svir_25280(thyX)
TBI: 
Tbis_1689
AMD: 
AMED_6305(thyX)
AMN: 
RAM_32335(thyX)
AMM: 
AMES_6214(thyX)
PDX: 
Psed_4654
AMI: 
Amir_5811(thyX)
SESP: 
BN6_69570(thyX)
STP: 
Strop_1388(thyX)
SAQ: 
Sare_1346(thyX)
MAU: 
Micau_1492
MIL: 
ML5_1754
VMA: 
VAB18032_12050(thyX)
CAI: 
Caci_7860(thyX)
SNA: 
Snas_4274
RXY: 
Rxyl_2633
CCU: 
Ccur_09250
SHI: 
Shel_20020
ELE: 
Elen_1128
EYY: 
EGYY_10600(THY1)
GPA: 
GPA_31450
BBZ: 
BbuZS7_A66(thyX)
BBN: 
BbuN40_A76(thyX)
BBJ: 
BbuJD1_A76(thyX)
BGB: 
KK9_1001
BAF: 
BAPKO_2074(thyX)
BAFZ: 
BafPKo_A0070(thyX)
BBS: 
BbiDN127_A0070(thyX)
BDU: 
BDU_1078 BDU_16004(thyX)
BRE: 
BRE_1048 BRE_3005(thyX)
BCW: 
Q7M_1005 Q7M_1079
TPA: 
TP1007(thyX)
TPP: 
TPASS_1007(thyX)
TPU: 
TPADAL_1007(thyX)
TPH: 
TPChic_1007
TPO: 
TPAMA_1007(thyX)
TPC: 
TPECDC2_1007(thyX)
TPG: 
TPEGAU_1007(thyX)
TPM: 
TPESAMD_1007(thyX)
TPB: 
TPFB_1007(thyX)
TDE: 
TDE0311(thyX)
TSU: 
Tresu_2321
TBE: 
Trebr_0483
TAZ: 
TREAZ_1782(thyX)
TPI: 
TREPR_3849(thyX)
TPL: 
TPCCA_1007(thyX)
SSM: 
Spirs_4106
STA: 
STHERM_c22080
STQ: 
Spith_2253
SCC: 
Spico_1594
SCD: 
Spica_0046
SFC: 
Spiaf_2813
LBI: 
LEPBI_I3300(thyX)
LBF: 
LBF_3186
SBU: 
SpiBuddy_0773
SGP: 
SpiGrapes_1238
PDT: 
Prede_1189
GAU: 
GAU_0458(thyX)
PLM: 
Plim_0014
PBS: 
Plabr_0796
EMI: 
Emin_0062(thyX)
RSD: 
TGRD_526
TAI: 
Taci_0819
ACO: 
Amico_0723
TLI: 
Tlie_0744
AMO: 
Anamo_0651
SYN: 
sll1635(thyX)
SYZ: 
MYO_15040
SYY: 
SYNGTS_0498(dgt)
SYT: 
SYNGTI_0498(dgt)
SYS: 
SYNPCCN_0498(dgt)
SYQ: 
SYNPCCP_0498(dgt)
SYW: 
SYNW0279(thyX)
SYC: 
syc0504_d
SYF: 
Synpcc7942_1044
SYD: 
Syncc9605_0273
SYE: 
Syncc9902_2071
SYG: 
sync_0320(thyX)
SYR: 
SynRCC307_2347(thyX)
SYX: 
SynWH7803_0323(thyX)
CYA: 
CYA_0237(thyX)
CYB: 
CYB_1781(thyX)
SYNE: 
Syn6312_1820
SYNP: 
Syn7502_00393
AMR: 
AM1_4458(thyX)
CGC: 
Cyagr_2015
CAN: 
Cyan10605_1656
CSN: 
Cyast_0688
HAO: 
PCC7418_3383
GVI: 
glr2321(thyX)
ANA: 
alr0515
NPU: 
Npun_R2526
NOS: 
Nos7107_2097
AVA: 
Ava_2917
CALO: 
Cal7507_0201
RIV: 
Riv7116_5315
PMA: 
Pro0273(thyX)
PMM: 
PMM0243(thyX)
PMT: 
PMT1550(thyX)
PMN: 
PMN2A_1609(thyX)
PMI: 
PMT9312_0245(thyX)
PMB: 
A9601_02651(thyX)
PMC: 
P9515_02761(thyX)
PMF: 
P9303_03851(thyX)
PMG: 
P9301_02661(thyX)
PMH: 
P9215_02661(thyX)
PMJ: 
P9211_02681(thyX)
PME: 
NATL1_03211(thyX)
LEP: 
Lepto7376_0774
GEI: 
GEI7407_1669
OAC: 
Oscil6304_4779
PSEU: 
Pse7367_2950
MIC: 
Mic7113_4632
ARP: 
NIES39_Q01490
SCS: 
Sta7437_0046
CTE: 
CT1554(thyX)
CPC: 
Cpar_0404(thyX)
CCH: 
Cag_0390(thyX)
CPH: 
Cpha266_2031(thyX)
CPB: 
Cphamn1_2038(thyX)
CLI: 
Clim_0404(thyX)
PVI: 
Cvib_0423(thyX)
PLT: 
Plut_0366(thyX)
PPH: 
Ppha_2383(thyX)
PAA: 
Paes_1838(thyX)
CTS: 
Ctha_1238(thyX)
DET: 
DET1489(thyX)
DEH: 
cbdb_A1457(thyX)
DEB: 
DehaBAV1_1279
DEV: 
DhcVS_1265(thyX)
DEG: 
DehalGT_1193
DMC: 
btf_1357(thyX)
DMD: 
dcmb_1343(thyX)
DLY: 
Dehly_1032
DGE: 
Dgeo_2027
DMR: 
Deima_3058
DGO: 
DGo_CA2416(thyX)
DPD: 
Deipe_3024
TRA: 
Trad_0036
TTH: 
TTC0731(thyX)
TTJ: 
TTHA1096(thyX)
TTS: 
Ththe16_1106
TTL: 
TtJL18_0963
TSC: 
TSC_c17940(thyX)
TOS: 
Theos_0616
OPR: 
Ocepr_1015 Ocepr_2273
MHD: 
Marky_1352
AAE: 
aq_640(thy)
HYA: 
HY04AAS1_0508
HHO: 
HydHO_0497
HYS: 
HydSN_0507
HTH: 
HTH_1369(thyX)
HTE: 
Hydth_1360
TAL: 
Thal_0890
SUL: 
SYO3AOP1_0919
SAF: 
SULAZ_0112
PMX: 
PERMA_1648
TAM: 
Theam_0773
DTE: 
Dester_0323
TMA: 
TM0449(thyX)
TPT: 
Tpet_0471(thyX)
TLE: 
Tlet_1637(thyX)
TRQ: 
TRQ2_0486(thyX)
TNA: 
CTN_0223(thyX)
TNP: 
Tnap_0231
TTA: 
Theth_0047
TME: 
Tmel_1909(thyX)
TAF: 
THA_203(thyX)
FNO: 
Fnod_1336(thyX)
FPE: 
Ferpe_1758
PMO: 
Pmob_1229(thyX)
KOL: 
Kole_0028(thyX)
MPZ: 
Marpi_1954
MPG: 
Theba_0527
DTH: 
DICTH_0644(thyX)
DTU: 
Dtur_0802
TYE: 
THEYE_A0969(thyX)
LFC: 
LFE_2050(thyX)
LFI: 
LFML04_2249
DDF: 
DEFDS_0098
CNI: 
Calni_0294
FSI: 
Flexsi_1957
TID: 
Thein_1190
CEX: 
CSE_02010(thyX)
TTR: 
Tter_0028
MOX: 
DAMO_1621
APO: 
Arcpr_0253
HAL: 
VNG1325C
HSL: 
OE2898R(thyX)
HMA: 
rrnAC1121(thyX)
HHI: 
HAH_1727(thyX)
HUT: 
Huta_2890
HJE: 
HacjB3_07690
TAR: 
TALC_01498
PHO: 
PH0762(thyX)
PAB: 
PAB0861(thyX)
PFU: 
PF0540(thyX)
PFI: 
PFC_01825(thyX)
PYN: 
PNA2_1390
PYA: 
PYCH_07100
TKO: 
TK0870(thyX)
TON: 
TON_0437(thyX)
TGA: 
TGAM_1151(thyX)
TSI: 
TSIB_1584(thyX)
TBA: 
TERMP_00049
THE: 
GQS_03025(thyX)
THA: 
TAM4_1954
THM: 
CL1_0251
ABI: 
Aboo_0523
ACF: 
AciM339_0519
MAX: 
MMALV_16220
APE: 
APE_2064.1(thyX)
SMR: 
Smar_1078
SHC: 
Shell_1399
IHO: 
Igni_1422
DKA: 
DKAM_1120
DMU: 
Desmu_1128
DFD: 
Desfe_1235
TAG: 
Tagg_0922
IAG: 
Igag_0648
THG: 
TCELL_0370
HBU: 
Hbut_0853
PFM: 
Pyrfu_0851
SSO: 
SSO0321
SOL: 
Ssol_1297
STO: 
ST2215
SAI: 
Saci_2347(thyX)
SACN: 
SacN8_11440
SACR: 
SacRon12I_11685
SIS: 
LS215_1920
SIA: 
M1425_1780
SIM: 
M1627_1898
SID: 
M164_1828
SIY: 
YG5714_1897
SIN: 
YN1551_1028
SII: 
LD85_2038
SIH: 
SiH_1756
SIR: 
SiRe_1676
SIC: 
SiL_1670
MSE: 
Msed_1894
MCN: 
Mcup_0390
AHO: 
Ahos_1198
PAI: 
PAE1837
PIS: 
Pisl_1753
PCL: 
Pcal_0501
PAS: 
Pars_0709
PYR: 
P186_0130
POG: 
Pogu_1633
TNE: 
Tneu_0769
CMA: 
Cmaq_1148 Cmaq_1625
TUZ: 
TUZN_0548
TTN: 
TTX_0934(thyX)
VDI: 
Vdis_1532
VMO: 
VMUT_0080
ASC: 
ASAC_1131
CLG: 
Calag_0404
FFO: 
FFONT_0957
NEQ: 
NEQ015
KCR: 
Kcr_0351
HAH: 
Halar_1642
 » show all
Taxonomy
Reference
1  [PMID:12029065]
  Authors
Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U.
  Title
An alternative flavin-dependent mechanism for thymidylate synthesis.
  Journal
Science. 297 (2002) 105-7.
  Organism
Dictyostelium discoideum [GN:ddi], Rickettsia prowazekii [GN:rpr], Borrelia burgdorferi [GN:bbu], Treponema pallidum [GN:tpa], Pyrococcus horikoshii [GN:pho], Pyrococcus abyssi [GN:pab], Helicobacter pylori, Campylobacter jejuni, Mycobacterium tuberculosis, Chlamydia sp., Sulfolobus solfaraticus
Reference
2  [PMID:15591067]
  Authors
Griffin J, Roshick C, Iliffe-Lee E, McClarty G
  Title
Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
  Journal
J. Biol. Chem. 280 (2005) 5456-67.
Reference
3  [PMID:16707489]
  Authors
Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U
  Title
Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase  ThyX.
  Journal
J. Biol. Chem. 281 (2006) 24048-57.
Reference
4  [PMID:19370033]
  Authors
Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A
  Title
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
  Journal
Nature. 458 (2009) 919-23.
Reference
5  [PMID:19643076]
  Authors
Koehn EM, Kohen A
  Title
Flavin-dependent thymidylate synthase: a novel pathway towards thymine.
  Journal
Arch. Biochem. Biophys. 493 (2010) 96-102.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
850167-13-4
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