KEGG   ENZYME: 2.1.1.148Help
Entry
EC 2.1.1.148                Enzyme                                 

Name
thymidylate synthase (FAD);
Thy1;
ThyX
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+ [RN:R06613]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
dUMP [CPD:C00365];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
dTMP [CPD:C00364];
tetrahydrofolate [CPD:C00101];
NADP+ [CPD:C00006]
Comment
Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.
History
EC 2.1.1.148 created 2003, modified 2010
Pathway
ec00240  Pyrimidine metabolism
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K03465  thymidylate synthase (FAD)
Genes
DDI: DDB_G0280045(thyA)
DPP: DICPUDRAFT_149635
DFA: DFA_07108(thyA)
PLF: PANA5342_0664
PAGG: AL522_18775(thyX)
VVM: VVMO6_03564
PPUN: PP4_02980(thyX)
MCS: DR90_1124(thyX)
MBL: AAX09_07615
MSX: AU14_17405
GNI: GNIT_1810(thyX)
HPY: HP1533(thyX)
HEO: C694_07940(thyX)
HPJ: jhp_1421
HPS: HPSH_07875(thyX)
HHP: HPSH112_07735(thyX)
HHQ: HPSH169_07545(thyX)
HHR: HPSH417_07460(thyX)
HPB: HELPY_1504(thyX)
HPL: HPB8_1709(thyX)
HPC: HPPC_07505(thyX)
HCA: HPPC18_06950(thyX)
HPM: HPSJM_07820(thyX)
HPE: HPELS_07885(thyX)
HPO: HMPREF4655_20125(thyX)
HPI: hp908_1519(thyX)
HPQ: hp2017_1462(thyX)
HPW: hp2018_1467(thyX)
HPU: HPCU_07700(thyX)
HEF: HPF16_1427(thyX)
HPF: HPF30_1404(thyX)
HEQ: HPF32_1418(thyX)
HEX: HPF57_1445(thyX)
HPT: HPSAT_07370(thyX)
HPZ: HPKB_1434(thyX)
HPV: HPV225_1486(thyX)
HPX: HMPREF0462_1530(thyX)
HEN: HPSNT_07590(thyX)
HPH: HPLT_07625(thyX)
HEG: HPGAM_08080(thyX)
HPN: HPIN_07455(thyX)
HEP: HPPN120_07520(thyX)
HEU: HPPN135_07730(thyX)
HES: HPSA_07320(thyX)
HPYS: HPSA20_1605(thyX)
HCN: HPB14_07370(thyX)
HPD: KHP_1384
HER: C695_07960(thyX)
HEI: C730_07945(thyX)
HPYA: HPAKL117_07360(thyX)
HPYK: HPAKL86_00215(thyX)
HPYO: HPOK113_1447(thyX)
HPYL: HPOK310_1415(thyX)
HPYR: K747_03525
HPYI: K750_01165
HPYU: K751_00095
HPYM: K749_06290
HEB: U063_1550
HEZ: U064_1554
HAC: Hac_1786(thyX)
HMS: HMU13850(thyX)
HFE: HFELIS_01720(thyX)
HCE: HCW_01300(thyX)
HCM: HCD_04640(thyX)
HCP: HCN_2087(thyX)
HCB: HCBAA847_2360(thyX)
WSU: WS2228
SUA: Saut_0012
SULR: B649_00490
CJE: Cj0026c(thyX)
CJB: BN148_0026c(thyX)
CJJ: CJJ81176_0053(thyX)
CJU: C8J_0025
CJI: CJSA_0026(thyX)
CJM: CJM1_0024(thyX)
CJS: CJS3_0026(thyX)
CJP: A911_00125(thyX)
CJEJ: N564_00025
CJEU: N565_00025
CJEN: N755_00025
CJEI: N135_00026
CJER: H730_00135(thyX)
CJV: MTVDSCj20_0025(thyX)
CJY: QZ67_00028(thyX)
CJQ: UC78_0025(thyX)
CJR: CJE0026(thyX)
CJD: JJD26997_0028(thyX)
CFF: CFF8240_1800(thyX)
CFT: CFF04554_1792(thyX)
CFV: CFVI03293_1853(thyX)
CFX: CFV97608_1963(thyX)
CFZ: CSG_19680
CAMP: CFT03427_1740(thyX)
CCV: CCV52592_2063(thyX)
CHA: CHAB381_1762(thyX)
CCO: CCC13826_1861(thyX)
CCOC: CCON33237_1844(thyX)
CLA: Cla_0011(thyX)
CLR: UPTC16701_0014(thyX)
CLM: UPTC16712_0014(thyX)
CLQ: UPTC4110_0014(thyX)
CLN: UPTC3659_0016(thyX)
CLL: CONCH_0009(thyX)
CCC: G157_00125(thyX)
CCQ: N149_0025(thyX)
CCF: YSQ_00135
CCY: YSS_00135
CCOI: YSU_00140
CCOF: VC76_00130(thyX)
CCOO: ATE51_00050(thyX)
CAJ: CIG1485E_1696(thyX)
CIS: CINS_0012(thyX)
CVO: CVOL_0011(thyX)
CPEL: CPEL_0010(thyX)
CAMR: CAQ16704_0008(thyX)
CSM: CSUB8521_0010(thyX)
CSF: CSUB8523_0009(thyX)
CGRA: CGRAC_1527(thyX)
CURE: CUREO_1669(thyX)
CHYO: CHH_1789(thyX)
CHV: CHELV3228_1593(thyX)
CSPF: CSF_0243(thyX)
CPIN: CPIN18020_1653(thyX)
CCUN: CCUN_1868(thyX)
CLX: CLAN_1468(thyX)
ABU: Abu_2330(thyX)
ABT: ABED_2154
ABL: A7H1H_2296(thy)
ARC: ABLL_2840
SDL: Sdel_0001
SMUL: SMUL_3300(thyX)
SHAL: SHALO_3021
SULJ: SJPD1_2898
NIS: NIS_1855
SUN: SUN_2288
GSU: GSU3106(thyX)
GSK: KN400_3045(thyX)
GME: Gmet_0378(thyX)
GUR: Gura_4063
GLO: Glov_1027
GBM: Gbem_3711(thyX)
GEO: Geob_0683(thyX)
GEM: GM21_3806
GEB: GM18_4159
PCA: Pcar_2693(thyX)
PPD: Ppro_2649
DES: DSOUD_3200(thyX)
DEU: DBW_3273
DVU: DVU2254(thyX)
DVL: Dvul_0990
DVM: DvMF_3206
DDE: Dde_2321
DDS: Ddes_0584
DMA: DMR_30810(thyX)
DHY: DESAM_21281(thyX)
DGG: DGI_3451(thyX)
DAS: Daes_2190
DPI: BN4_20531(thyX)
PPRF: DPRO_4028(thyX)
LIP: LI1188(thyA)
LIR: LAW_01225(thyX)
DBA: Dbac_3494
DRT: Dret_1744
DPS: DP2228
DSF: UWK_02359
DML: Dmul_21130(thyX)
DAT: HRM2_18050(thyX)
ADE: Adeh_1139
DBR: Deba_1514
DPB: BABL1_gene_161(thyX)
RPR: RP301(thyX)
RPO: MA1_01460(thyX)
RPW: M9W_01465(thyX)
RPZ: MA3_01480(thyX)
RPG: MA5_02830(thyX)
RPS: M9Y_01470(thyX)
RPV: MA7_01460(thyX)
RPQ: rpr22_CDS295(thyX)
RPL: H375_3130
RPN: H374_7790
RTY: RT0292(thyA)
RTT: RTTH1527_01420(thyX)
RTB: RTB9991CWPP_01425(thyX)
RCM: A1E_04060
RCC: RCA_03710(thyX)
RBE: RBE_0275(thyX)
RBO: A1I_06415(thyX)
RCO: RC0405(thyA)
RFE: RF_0491(thyX)
RAK: A1C_02260(thyX)
RRI: A1G_02310(thyX)
RRJ: RrIowa_0486(thyX)
RRA: RPO_02290(thyX)
RRC: RPL_02280(thyX)
RRH: RPM_02270(thyX)
RRB: RPN_04620(thyX)
RRN: RPJ_02270(thyX)
RRP: RPK_04170(thyX)
RRM: RRM_02215
RRR: RRR_02200
RMS: RMA_0415(thyX)
RMI: RMB_06055(thyX)
RPK: RPR_04355(thyX)
RAF: RAF_ORF0379(thyX)
RHE: Rh054_02320(thyX)
RJA: RJP_0321(thyX)
RSV: Rsl_479(thyX)
RSW: MC3_02320(thyX)
RPH: RSA_02235(thyX)
RAU: MC5_05880(thyX)
RMO: MCI_06210(thyX)
RPP: MC1_02280(thyX)
RRE: MCC_02865(thyX)
RAM: MCE_02830(thyX)
RMC: RMONA_04670(thyX)
OTS: OTBS_0340(thyX)
OTT: OTT_1076(thyA)
WOL: WD_1198
WRI: WRi_011720(thyX)
WEN: wHa_10000(thyX)
WED: wNo_04220(thyX)
WPI: WP0761(thyX)
WBM: Wbm0741
WOO: wOo_03250
WCL: WCLE_006330(thyX)
AMA: AM170(thyl)
AMF: AMF_127(thy1)
ACN: ACIS_01106(thyX)
APH: APH_0163(thyX)
APY: YYU_00800
APD: YYY_00795
APHA: WSQ_00795
ERU: Erum6790(probable_thy1)
ERW: ERWE_CDS_07140(thyX)
ERG: ERGA_CDS_07060(thyX)
ECN: Ecaj_0686
ECH: ECH_0317(thyX)
ECHA: ECHHL_0266(thyX)
ECHJ: ECHJAX_0791(thyX)
ECHL: ECHLIB_0795(thyX)
ECHS: ECHOSC_0275(thyX)
ECHV: ECHSTV_0781(thyX)
ECHW: ECHWAK_0788(thyX)
ECHP: ECHWP_0264(thyX)
EHH: EHF_0273(thyX)
NSE: NSE_0163(thyX)
NRI: NRI_0159(thyX)
NHM: NHE_0147(thyX)
RBT: NOVO_03045(thyX)
PACA: ID47_10200
EAA: I862_03245(thyX)
AZC: AZC_2577(thyX) AZC_3595
BID: Bind_0769
MTW: CQW49_18435(thyX)
RBM: TEF_21200
SIL: SPO1273(thyX)
RCP: RCAP_rcc03041(thyX)
JAN: Jann_1091
PDE: Pden_0934
DSH: Dshi_0768
KVU: EIO_0175(thyX)
KVL: KVU_1514(thyX)
KRO: BVG79_01631(thyX)
OAR: OA238_c06750(thyX)
OTM: OSB_09910(thyX)
MALG: MALG_00712
RSU: NHU_01590
RHC: RGUI_3358
SPSE: SULPSESMR1_00778(thyX)
RMM: ROSMUCSMR3_00565(thyX)
LVS: LOKVESSMR4R_00889(thyX)
GOX: GOX1427
GOH: B932_1676
GOY: GLS_c15440(thyX)
ACR: Acry_0045
AMV: ACMV_00690(thyX)
GDI: GDI0868(thyX)
GDJ: Gdia_1151
GXY: GLX_20430(thyX)
GXL: H845_2938
KEU: S101446_02525(thyX)
APK: APA386B_1303(thyX)
ASZ: ASN_1205(thyX)
ABG: Asbog_00660(thyX)
RRU: Rru_A2792(thyX)
RRF: F11_14325
MGY: MGMSRv2__3516(thyX)
AZL: AZL_019310(thy1)
ALI: AZOLI_1878(thyX)
ABS: AZOBR_100091(thyX)
TMO: TMO_2448(thyX)
MGM: Mmc1_0404
PUB: SAR11_0010(thyX)
AFR: AFE_0732(thyX)
ACU: Atc_1778
BAO: BAMF_0917(thyX)
BAN: BA_3813
BAI: BAA_3835
BANT: A16_38160
BANR: A16R_38590
BANS: BAPAT_3646
BANV: DJ46_2516(thyX)
BCZ: BCE33L3445(thyX)
BGY: BGLY_1515
BKW: BkAM31D_02200(thyX)
PPQ: PPSQR21_032520(tHY1)
PRI: PRIO_1100
PDH: B9T62_18380(thyX)
TAB: CIG75_11525(thyX)
CPE: CPE2425
CPF: CPF_2735(thyX)
CPR: CPR_2421(thyX)
CTC: CTC_02620
CTET: BN906_02878(thyX)
CNO: NT01CX_1095(thyX)
CBO: CBO3500(thyX)
CBA: CLB_3559(thyX)
CBH: CLC_3448(thyX)
CBY: CLM_3970(thyX)
CBL: CLK_2946(thyX)
CBB: CLD_1002(thyX)
CBI: CLJ_B3811(thyX)
CBN: CbC4_0208(thyX)
CBF: CLI_3686(thyX)
CBM: CBF_3672(thyX)
CKL: CKL_2204(thyX)
CKR: CKR_1938
CPAS: Clopa_4535
CPAT: CLPA_c36960(thyX)
CPAE: CPAST_c36960(thyX)
CSQ: CSCA_4266
CLD: CLSPO_c36650(thyX)
CACE: CACET_c36420(thyX)
AMT: Amet_4498
AOE: Clos_0472
CCEL: CCDG5_1027
CTHD: CDO33_04405(thyX)
RBR: RBR_09150
RUS: RBI_I01407(thyX)
FPR: FP2_05300
RIX: RO1_14650
RIM: ROI_22860
CCT: CC1_26290
ERT: EUR_29810
CDF: CD630_00540(thyX)
PDC: CDIF630_00118(thyX)
PDF: CD630DERM_00540(thyX)
EAC: EAL2_c01370(thyX)
CST: CLOST_2223(thyX)
PBQ: C3V37_03500(thyX)
SWO: Swol_2353
SLP: Slip_2257
DSY: DSY0449
DHD: Dhaf_0400
PTH: PTH_0298(THY1)
DAU: Daud_0189
SGY: Sgly_0494
ELM: ELI_3381
EHL: EHLA_1529
AWO: Awo_c11000(thyX)
CTHM: CFE_2690
CHY: CHY_2336(thyX)
TAE: TepiRe1_2338(thyX)
MTA: Moth_2482
ADG: Adeg_0404
TPZ: Tph_c04940(thyX)
CSC: Csac_1367
ATE: Athe_2044
TOC: Toce_2112
TACI: TDSAC_1494
FMA: FMG_0416
APR: Apre_0772
PED: ING2D1G_0513(thyX)
CAD: Curi_c22850(thyX)
SRI: SELR_07700(thyX)
MHG: MHY_11790
PFT: JBW_03906
AIN: Acin_0961(thyX)
EUC: EC1_04720
LPIL: LIP_0182
MTU: Rv2754c(thyX)
MTC: MT2824(thyX)
MRA: MRA_2779(thyX)
MTG: MRGA327_16890(thyX)
MTI: MRGA423_17100(thyX)
MTUR: CFBS_2907(thyX)
MTO: MTCTRI2_2807(thyX)
MTD: UDA_2754c(thyX)
MTN: ERDMAN_3019(thyX)
MTJ: J112_14755(thyX)
MTUC: J113_19120(thyX)
MTUE: J114_14695(thyX)
MTX: M943_14230(thyX)
MTUH: I917_19310(thyX)
MTUL: TBHG_02686
MTUT: HKBT1_2898(thyX)
MTUU: HKBT2_2901(thyX)
MTQ: HKBS1_2905(thyX)
MBO: BQ2027_MB2775C(thyx)
MBB: BCG_2770c
MBT: JTY_2764(thyX)
MBM: BCGMEX_2763c(thyX)
MBX: BCGT_2586
MBZ: LH58_14630(thyX)
MAF: MAF_27590(thyX)
MCE: MCAN_27811(thyX)
MCQ: BN44_60214(thyX)
MCV: BN43_40438(thyX)
MCX: BN42_40733(thyX)
MCZ: BN45_51138(thyX)
MMIC: RN08_3040
MLE: ML1514(thyX)
MLB: MLBr01514
MPA: MAP_2865c
MAO: MAP4_0943
MAVI: RC58_04635(thyX)
MAVU: RE97_04635(thyX)
MAV: MAV_3645(thyX)
MAVD: NF84_16580(thyX)
MAVR: LA63_16735(thyX)
MAVA: LA64_16730(thyX)
MIT: OCO_34730
MIA: OCU_34780
MIE: LG41_16435(thyX)
MID: MIP_05230
MYO: OEM_35180
MIR: OCQ_35950
MCHI: AN480_18405(thyX)
MMAL: CKJ54_16260(thyX)
MUL: MUL_2183(thyX)
MMC: Mmcs_2115
MKM: Mkms_2161
MJL: Mjls_2102
MMI: MMAR_1961(thyX)
MMAE: MMARE11_18850(thyX)
MMM: W7S_17375(thyX)
MLI: MULP_02127(thyX)
MKS: LG40_24865(thyX)
MKI: LH54_24995(thyX)
MYV: G155_12640(thyX)
MYE: AB431_11605(thyX)
MHAD: B586_14800(thyX)
MDX: BTO20_22225(thyX)
MSM: MSMEG_2683(thyX)
MSG: MSMEI_2618(thyX)
MSB: LJ00_13350(thyX)
MSN: LI99_13355(thyX)
MSH: LI98_13360(thyX)
MVA: Mvan_2386
MGI: Mflv_4001
MGO: AFA91_26060(thyX)
MPHL: MPHLCCUG_03163(thyX)
MVQ: MYVA_2260(thyX)
MLL: B1R94_17555(thyX)
MAB: MAB_3085c
MMV: MYCMA_07200(thyX)
MABB: MASS_3025
MAY: LA62_15665(thyX)
MABO: NF82_15430(thyX)
MAZ: LA61_15565(thyX)
MAK: LH56_08690(thyX)
MYS: NF92_08835(thyX)
MYC: NF90_08835(thyX)
MCHE: BB28_15620(thyX)
MIZ: BAB75_16600(thyX)
MSTE: MSTE_03065(thyX)
MJD: JDM601_2504(thyX)
ASD: AS9A_1646
CGL: NCgl1897(thyX)
CGB: cg2162
CGU: WA5_1897(ThyX)
CGT: cgR_1801
CGS: C624_09535(thyX)
CGG: C629_09545(thyX)
CGM: cgp_2162(thyX)
CGJ: AR0_09300
CEF: CE1865
CDI: DIP1465
CDE: CDHC02_1363(thyX2)
CDR: CDHC03_1386(thyX2)
CDA: CDHC04_1386(thyX2)
CDZ: CD31A_1483(thyX2)
CDS: CDC7B_1108(thyX1) CDC7B_1468(thyX2)
CDD: CDCE8392_1384(thyX2)
CDV: CDVA01_1348(thyX2)
CDIP: ERS451417_01102(thyX1) ERS451417_01490(thyX)
CJK: jk1130
CUR: cu0861
CPU: cpfrc_01269(thyX)
CPL: Cp3995_1298(thyX)
CPG: Cp316_1317(thyX)
CPP: CpP54B96_1288(thyX)
CPK: Cp1002_1264(thyX)
CPQ: CpC231_1263(thyX)
CPX: CpI19_1270(thyX)
CPZ: CpPAT10_1262(thyX)
COR: Cp267_1322(thyX)
COP: Cp31_1281(thyX)
COD: Cp106_1245(thyX)
COS: Cp4202_1255(thyX)
COI: CpCIP5297_1288(thyX)
COE: Cp258_1285(thyX)
COU: Cp162_1264(thyX)
CPSE: CPTA_01844
CPSU: CPTB_01918
CPSF: CPTC_01838
CRD: CRES_1224(thyX)
CUL: CULC22_01375(thyX)
CUC: CULC809_01362(thyX)
CUE: CULC0102_1492(thyX)
CUN: Cul210932_1445(thyX)
CUS: CulFRC11_1349(thyX)
CUQ: Cul210931_1333(thyX)
CUZ: Cul05146_1409(thyX)
CUJ: CUL131002_1363c(thyX)
CVA: CVAR_0854(thyX1) CVAR_1631(thyX2)
CHN: A605_08550(thyX)
CCN: H924_08280(thyX)
CTER: A606_06540(thyX)
CMD: B841_07920(thyX)
CFN: CFAL_06300(thyX)
CCG: CCASEI_06250(thyX)
CVT: B843_08180(thyX)
CGY: CGLY_07745(thyX)
COA: DR71_2045(thyX)
CHM: B842_07910(thyX)
CSX: CSING_08265(thyX)
CMQ: B840_07560(thyX)
CKU: UL82_06315(thyX)
CCJ: UL81_07120(thyX)
CMV: CMUST_09235(thyX)
CEI: CEPID_07565(thyX)
CTED: CTEST_07945(thyX)
CUT: CUTER_06630(thyX)
CDX: CDES_08830(thyX)
CSP: WM42_2436(thyX)
CPHO: CPHO_04970
CGV: CGLAU_07610(thyX)
CAQU: CAQU_07550
CAMG: CAMM_05780
BFV: C628_09500(thyX)
NFR: ERS450000_03485(thyX)
RER: RER_27310(thyX)
REY: O5Y_12540(thyX)
REB: XU06_12755(thyX)
ROP: ROP_67320(thyX)
REQ: REQ_19410(thyX)
RPY: Y013_01420(thyX)
RHB: NY08_1315
RAV: AAT18_11790(thyX)
RFA: A3L23_04549(thyX)
RHW: BFN03_06090(thyX)
RHS: A3Q41_03720(thyX)
RRZ: CS378_01565(thyX)
RHU: A3Q40_01443(thyX)
RQI: C1M55_13795(thyX)
GBR: Gbro_2189
GPO: GPOL_c20830(thyX)
GOR: KTR9_2106
GOQ: ACH46_08975(thyX)
GTA: BCM27_11295(thyX)
GOC: CXX93_13950(thyX)
GIT: C6V83_09455(thyX)
DIT: C3V38_14730(thyX)
DIZ: CT688_08890(thyX)
CBQ: AL705_00945(thyX)
SCO: SCO5743(thyX)
SMA: SAVERM_2517(thyX)
SGR: SGR_1777
SGB: WQO_26630
SCT: SCAT_4515(thyX)
SFA: Sfla_1607
SBH: SBI_03362(thyX)
SHY: SHJG_6830
SVE: SVEN_5392
SDV: BN159_2705(thyX)
SALB: XNR_1124
SALS: SLNWT_1543
STRP: F750_5251(thyX)
SFI: SFUL_5660
SCI: B446_26860(thyX)
SALU: DC74_5826
SALL: SAZ_30835
SLV: SLIV_09920(thyX)
SGU: SGLAU_24720(thyX)
STRE: GZL_03016
SLD: T261_2346
STRM: M444_25315
SAMB: SAM23877_5445(thyX) SAM23877_p107(thyX)
SPRI: SPRI_2159
SRW: TUE45_06236(thyX)
SLE: sle1_013 sle_19260(sle_19260)
SRN: A4G23_04257(thyX)
SNR: SNOUR_13085(thyX)
STRD: NI25_10525
SMAL: SMALA_5667
SLAU: SLA_5609
SLX: SLAV_11240(thyX)
KSK: KSE_53330(thyX)
TWH: TWT_616(thyX)
TWS: TW633
CMI: CMM_2037(thyX)
CMS: CMS1197
CMC: CMN_01998(thyX)
AMIN: AUMI_13500
MALK: MalAC0309_1104(thyX)
BLIN: BLSMQ_2635
TFU: Tfu_1387
NDA: Ndas_1441
NAL: B005_4072(thyX)
NGV: CDO52_13570(thyX)
TCU: Tcur_2472
FAL: FRAAL5743(thyX)
ACE: Acel_1504
NML: Namu_2236
BSD: BLASA_3705(thyX)
MMAR: MODMU_4342(thyX)
SEN: SACE_5902(thyX)
AMD: AMED_6305(thyX)
AMN: RAM_32335(thyX)
AMM: AMES_6214(thyX)
AMZ: B737_6214(thyX)
AOI: AORI_2245(thyX)
AJA: AJAP_27655(thyX)
AMQ: AMETH_2478(thyX)
AMYC: CU254_24845(thyX)
AMYB: BKN51_03805(thyX)
PDX: Psed_4654
PSEA: WY02_24545(thyX)
PSEE: FRP1_18300(thyX)
PSEH: XF36_17515(thyX)
PSEQ: AD006_25755(thyX)
PECQ: AD017_05345(thyX)
PHH: AFB00_21290(thyX)
AMI: Amir_5811
APRE: CNX65_28485(thyX)
SESP: BN6_69570(thyX)
KAL: KALB_7181
KPHY: AOZ06_44015(thyX)
LED: BBK82_22680(thyX)
ACTI: UA75_09455
ACAD: UA74_09485
AHG: AHOG_08865(thyX)
ACTA: C1701_19860(thyX)
ALL: CRK58495
PMAD: BAY61_10505(thyX)
SAQ: Sare_1346
MIL: ML5_1754
VMA: VAB18032_12050(thyX)
PLAB: C6361_15745(thyX)
PLAT: C6W10_14615(thyX)
CAI: Caci_7860
SNA: Snas_4274
TBI: Tbis_1689
AEY: CDG81_07710(thyX) CDG81_09725(thyX)
RXY: Rxyl_2633
ELE: Elen_1128
EYY: EGYY_10600(THY1)
GPA: GPA_31450
AEQ: AEQU_1380
CBAC: JI75_02290
SYN: sll1635
SYZ: MYO_15040
SYY: SYNGTS_0498(dgt)
SYT: SYNGTI_0498(dgt)
SYS: SYNPCCN_0498(dgt)
SYQ: SYNPCCP_0498(dgt)
SYW: SYNW0279(thyX)
SYC: syc0504_d
SYG: sync_0320(thyX)
SYR: SynRCC307_2347(thyX)
SYX: SynWH7803_0323(thyX)
SYP: SYNPCC7002_A1309(thyX)
CYA: CYA_0237(thyX)
CYB: CYB_1781(thyX)
SYNR: KR49_10340
SYND: KR52_01115
SYH: Syncc8109_0272(thyX)
SYNW: SynWH8103_00302(thyx)
CYI: CBM981_1960(thyX)
PMA: Pro_0273(THY1)
PMM: PMM0243
PMT: PMT_1550
PMB: A9601_02651(thy1)
PMC: P9515_02761(thy1)
PMF: P9303_03851(thy1)
PMG: P9301_02661(thy1)
PMH: P9215_02661(thy1)
PMJ: P9211_02681(thy1)
PME: NATL1_03211(thy1)
PRC: EW14_0288
PRM: EW15_0336
AMR: AM1_4458(thyX)
CYL: AA637_10370(thyX)
TER: Tery_2082
GVI: glr2321(thyX)
GLJ: GKIL_2490(thyX)
ANA: alr0515
NOE: CLI64_07600(thyX)
AVA: Ava_2917
CALH: IJ00_06580
NSP: BMF81_03996(thyX)
DET: DET1489(thyX)
DEH: cbdbA1457(thyX)
DEV: DhcVS_1265(thyX)
DMC: btf_1357(thyX)
DMD: dcmb_1343(thyX)
DMG: GY50_1312(thyX)
DUC: UCH007_12340(thyX)
DFO: Dform_00406(thyX|thy1)
CAP: CLDAP_40180(thyX)
DGE: Dgeo_2027
DGO: DGo_CA2416(thyX)
TRA: Trad_0036
TTH: TT_C0731
TTJ: TTHA1096(thyX)
TSC: TSC_c17940(thyX)
TAQ: TO73_1738
TBC: A0O31_00462(thyX)
TTR: Tter_0028
PIR: VN12_19670(thyX)
PLM: Plim_0014
PLS: VT03_12590(thyX)
FMR: Fuma_05268(thyX)
TTF: THTE_3498
GES: VT84_39070(thyX)
PBU: L21SP3_01516(thyX)
PBAS: SMSP2_01449(thyX)
VBL: L21SP4_00335(thyX)
BBZ: BbuZS7_A66(thyX)
BBN: BbuN40_A76(thyX)
BBJ: BbuJD1_A76(thyX)
BGB: KK9_1001
BAF: BAPKO_2074(thyX)
BAFZ: BafPKo_A0070(thyX)
BAFT: P612_04505
BAFE: BAFK78_A070(thyX)
BBS: BbiDN127_A0070(thyX)
BCHI: OY14_04700
BDU: BDU_1078 BDU_16004(thyl)
BRE: BRE_1048 BRE_3005(thy1)
BANE: N187_A28(thyX)
TPA: TP_1007
TPW: TPANIC_1007(thyX)
TPP: TPASS_1007(thyX)
TPU: TPADAL_1007(thyX)
TPO: TPAMA_1007(thyX)
TPAS: TPSea814_001007(thyX)
TPC: TPECDC2_1007(thyX)
TPG: TPEGAU_1007(thyX)
TPM: TPESAMD_1007(thyX)
TPB: TPFB_1007(thyX)
TDE: TDE0311(thyX)
TAZ: TREAZ_1782(thyX)
TPI: TREPR_3849(thyX)
TPL: TPCCA_1007(thyX)
TPED: TPE_2648(thyX)
LBI: LEPBI_I3300(thyX)
LBF: LBF_3186
EMI: Emin_0062
EPO: Epro_0658(thyX)
ETI: RSTT_493(thyX)
RSD: TGRD_526
TAI: Taci_0819
TLI: Tlie_0744
GAU: GAU_0458(thyX)
GBA: J421_2361
CTE: CT1554(thyX)
CPC: Cpar_0404
CCH: Cag_0390
CLI: Clim_0404
PVI: Cvib_0423
PLT: Plut_0366
PPH: Ppha_2383
PAA: Paes_1838
PROC: Ptc2401_01929(thyX)
CTS: Ctha_1238
MRO: MROS_2726
AAE: aq_640(thy)
HTH: HTH_1369(thyX)
TAL: Thal_0890
TTK: TST_0350(thyX)
TMA: TM0449(thyX)
TMW: THMA_0455
TMQ: THMB_0455
TMX: THMC_0455
TPT: Tpet_0471
TRQ: TRQ2_0486
TNA: CTN_0223
TNP: Tnap_0231
THQ: T2812B_02440(thyX)
THZ: CELL2_02530(thyX)
TLE: Tlet_1637
TME: Tmel_1909
TAF: THA_203(thyX)
THER: Y592_01090
FNO: Fnod_1336
PMO: Pmob_1229
MARN: LN42_10355
DTN: DTL3_1861(thyX)
KOL: Kole_0028
CEX: CSE_02010(thyX)
CABY: Cabys_157(thyX)
DTH: DICTH_0644(thyX)
DTU: Dtur_0802
TYE: THEYE_A0969(thyX)
LFC: LFE_2050(thyX)
CTHI: THC_0276
MOX: DAMO_1621
HAL: VNG_1325C
HSL: OE_2898R(thyX)
HHB: Hhub_2372(thyX)
HMA: rrnAC1121(thyX)
HHI: HAH_1727(thyX)
HUT: Huta_2890
HTI: HTIA_2788
HARC: HARCEL1_07165(thyX)
MEAR: Mpt1_c00060(thyX)
MARC: AR505_0076
PHO: PH0762(PH0762)
PAB: PAB0861
PFU: PF0540
PFI: PFC_01825(thyX)
PYN: PNA2_1390
PYS: Py04_0716
TKO: TK0870
TON: TON_0437
TGA: TGAM_1151(thyX)
TSI: TSIB_1584
THE: GQS_03025(thyX)
THA: TAM4_1954
THM: CL1_0251
TLT: OCC_12019
THS: TES1_0152
TNU: BD01_0269
TEU: TEU_07070
PPAC: PAP_01565
ABI: Aboo_0523
APE: APE_2064.1(thyX)
ACJ: ACAM_1286(thyX)
SMR: Smar_1078
IHO: Igni_1422
IIS: EYM_00795
DKA: DKAM_1120
TAG: Tagg_0922
IAG: Igag_0648
HBU: Hbut_0853
SSO: SSO0321
SOL: Ssol_1297
SSOA: SULA_1340
SSOL: SULB_1341
SSOF: SULC_1339
STO: STK_22150(thyX)
SAI: Saci_2347(thyX)
SID: M164_1828
SII: LD85_2038
SIH: SiH_1756
SIR: SiRe_1676
SIC: SiL_1670
MSE: Msed_1894
MCN: Mcup_0390
AHO: Ahos_1198
PAI: PAE1837
PIS: Pisl_1753
PCL: Pcal_0501
PAS: Pars_0709
PYR: P186_0130
POG: Pogu_1633
TNE: Tneu_0769
TUZ: TUZN_0548
TTN: TTX_0934(thyX) TTX_1790
VDI: Vdis_1532
VMO: VMUT_0080
ASC: ASAC_1131
NEQ: NEQ015
KCR: Kcr_0351
BARC: AOA65_1489
 » show all
Taxonomy
Reference
1  [PMID:12029065]
  Authors
Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U.
  Title
An alternative flavin-dependent mechanism for thymidylate synthesis.
  Journal
Science. 297 (2002) 105-7.
  Sequence
[hpy:HP1533]
Reference
2  [PMID:15591067]
  Authors
Griffin J, Roshick C, Iliffe-Lee E, McClarty G
  Title
Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
  Journal
J. Biol. Chem. 280 (2005) 5456-67.
Reference
3  [PMID:16707489]
  Authors
Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U
  Title
Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase  ThyX.
  Journal
J. Biol. Chem. 281 (2006) 24048-57.
Reference
4  [PMID:19370033]
  Authors
Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A
  Title
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
  Journal
Nature. 458 (2009) 919-23.
  Sequence
[tma:TM0449]
Reference
5  [PMID:19643076]
  Authors
Koehn EM, Kohen A
  Title
Flavin-dependent thymidylate synthase: a novel pathway towards thymine.
  Journal
Arch. Biochem. Biophys. 493 (2010) 96-102.
Reference
6  [PMID:26823429]
  Authors
Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A
  Title
An unprecedented mechanism of nucleotide methylation in organisms containing thyX.
  Journal
Science. 351 (2016) 507-10.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.148
IUBMB Enzyme Nomenclature: 2.1.1.148
ExPASy - ENZYME nomenclature database: 2.1.1.148
BRENDA, the Enzyme Database: 2.1.1.148
CAS: 850167-13-4

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