KEGG   ENZYME: 2.1.1.184Help
Entry
EC 2.1.1.184                Enzyme                                 

Name
23S rRNA (adenine2085-N6)-dimethyltransferase;
ErmC' methyltransferase;
ermC methylase;
ermC 23S rRNA methyltransferase;
rRNA:m6A methyltransferase ErmC';
ErmC';
rRNA methyltransferase ErmC'
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (adenine2085-N6)-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA [RN:R10716]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine2085 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-dimethyladenine2085 in 23S rRNA
Comment
ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085.
History
EC 2.1.1.184 created 1976 as EC 2.1.1.48, part transferred 2010 to EC 2.1.1.184
Orthology
K00561  
23S rRNA (adenine-N6)-dimethyltransferase
Genes
PMP: 
Pmu_02850(erm(42))
BTO: 
BTRH: 
BTRA: 
NME: 
NMB0066(ermC)
BSUT: 
BLH: 
BHA: 
BCL: 
OIH: 
GMC: 
PTL: 
SAU: 
SA0048(ermA) SA0766(ermA) SA1480(ermA) SA1951(ermA) SA2384(ermA)
SAV: 
SAV0052(ermA) SAV1655(ermA)
SAW: 
SAHV_0051(ermA) SAHV_1642(ermA)
SAH: 
SAJ: 
SAR: 
SAR0050(ermA1) SAR1735(ermA2)
SAA: 
SUV: 
SUK: 
SUC: 
SUT: 
SUD: 
SUW: 
SAUN: 
SAUG: 
SAUZ: 
SAZ172_0044(ermA1) SAZ172_1667(ermA2)
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SUY: 
SAUM: 
SAUC: 
CA347_1648(ermA5) CA347_49(ermA5)
SAUR: 
SABB_02575(ermA1) SABB_05250(ermA2)
SER: 
SERP1220(ermA-1) SERP1343(ermA-2) SERP2510(ermA-3)
SHA: 
pSHaeB01(ermC)
SDT: 
SPSE_1800(ermA)
MCL: 
GYM: 
POW: 
SPI: 
SPW: 
SPX: 
SPG_1241(ermB)
SPV: 
SNC: 
SNB: 
SNP: 
SPAP_0896(erm(TR))
SPNN: 
SAGE: 
SSB: 
SSK: 
SSQ: 
SUI: 
SUO: 
SSUS: 
SOR: 
SOR_1880(ermB)
STD: 
SIU: 
SII_0641(ermB)
SANC: 
SANR_1363(ermTR)
SOI: 
SLU: 
LJH: 
LAI: 
EFA: 
EFD: 
EFC: 
EFAU: 
EFU: 
THL: 
AUR: 
AOE: 
RUK: 
HSD: 
CDF: 
PDC: 
CDIF630_02225(erm2(B)_1) CDIF630_02229(erm2(B)_2)
PDF: 
DDH: 
CAD: 
PED: 
TUR: 
MTU: 
Rv1988(erm(37))
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MAF: 
MCE: 
MCQ: 
MCZ: 
MMIC: 
MSM: 
MSG: 
MAB: 
MAY: 
MABO: 
MAZ: 
MYV: 
MFT: 
MVQ: 
MYVA_1303(erm(X))
CJK: 
jk1436(erm(X))
CUR: 
cu1922(erm(X))
CUA: 
CU7111_1847(erm(X))
CGY: 
CDO: 
CHM: 
CSX: 
CMV: 
NFA: 
NFR: 
NCY: 
NBR: 
NNO: 
GBR: 
TPR: 
SCO: 
SCO6089(SCBAC1A6.13)
SVL: 
SBH: 
SDV: 
BN159_2247(ermSF)
SRC: 
SLV: 
SLIV_07695(ermSF)
SXI: 
STRC: 
SAMB: 
MIX: 
ARI: 
BCV: 
KSE: 
LMOI: 
PPC: 
PBO: 
AACI: 
MPH: 
KFL: 
PSIM: 
AER: 
NDA: 
NAL: 
TCU: 
SRO: 
SEN: 
SACE_0733(ermE)
SVI: 
AJA: 
AMQ: 
ALU: 
PSEA: 
PSEH: 
PECQ: 
PHH: 
KAL: 
KPHY: 
AHM: 
STP: 
SAQ: 
AMS: 
AFS: 
CAI: 
SNA: 
BKS: 
TBI: 
CWO: 
EYY: 
TTR: 
BSA: 
BVS: 
PBT: 
PSN: 
RAG: 
DTN: 
SBE: 
WWE: 
MIB: 
 » show all
Taxonomy
Reference
1  [PMID:7543473]
  Authors
Zhong P, Pratt SD, Edalji RP, Walter KA, Holzman TF, Shivakumar AG, Katz L
  Title
Substrate requirements for ErmC' methyltransferase activity.
  Journal
J. Bacteriol. 177 (1995) 4327-32.
  Sequence
Reference
2  [PMID:2492520]
  Authors
Denoya C, Dubnau D
  Title
Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase.
  Journal
J. Biol. Chem. 264 (1989) 2615-24.
Reference
3  [PMID:2440853]
  Authors
Denoya CD, Dubnau D
  Title
Site and substrate specificity of the ermC 23S rRNA methyltransferase.
  Journal
J. Bacteriol. 169 (1987) 3857-60.
Reference
4  [PMID:9585521]
  Authors
Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C
  Title
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.
  Journal
Biochemistry. 37 (1998) 7103-12.
  Sequence
Reference
5  [PMID:10366505]
  Authors
Schluckebier G, Zhong P, Stewart KD, Kavanaugh TJ, Abad-Zapatero C
  Title
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
  Journal
J. Mol. Biol. 289 (1999) 277-91.
  Sequence
Reference
6  [PMID:12907737]
  Authors
Maravic G, Bujnicki JM, Feder M, Pongor S, Flogel M
  Title
Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.
  Journal
Nucleic. Acids. Res. 31 (2003) 4941-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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