KEGG   ENZYME: 2.1.1.2Help
Entry
EC 2.1.1.2                  Enzyme                                 

Name
guanidinoacetate N-methyltransferase;
GA methylpherase;
guanidinoacetate methyltransferase;
guanidinoacetate transmethylase;
methionine-guanidinoacetic transmethylase;
guanidoacetate methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine [RN:R01883]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanidinoacetate [CPD:C00581]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
creatine [CPD:C00300]
History
EC 2.1.1.2 created 1961
Pathway
Glycine, serine and threonine metabolism
Arginine and proline metabolism
Metabolic pathways
Orthology
K00542  
guanidinoacetate N-methyltransferase
Genes
HSA: 
2593(GAMT)
PTR: 
749982(GAMT)
PPS: 
100973784(GAMT)
GGO: 
101150449(GAMT)
PON: 
100434735(GAMT)
MCC: 
721263(GAMT)
MCF: 
102120326(GAMT)
MMU: 
14431(Gamt)
RNO: 
25257(Gamt)
CGE: 
100755964(Gamt)
HGL: 
101701700(Gamt)
TUP: 
102486225(GAMT)
CFA: 
485085(GAMT)
AML: 
FCA: 
101096703(GAMT)
PTG: 
102972234(GAMT)
BTA: 
515270(GAMT)
BOM: 
102277266(GAMT)
PHD: 
102317697(GAMT)
CHX: 
102176603(GAMT)
SSC: 
100625146(GAMT)
CFR: 
102522185(GAMT)
BACU: 
102999076(GAMT)
LVE: 
103069008(GAMT)
ECB: 
100068840(GAMT)
MYB: 
102240125(GAMT)
MYD: 
102765033(GAMT)
PALE: 
102878441(GAMT)
MDO: 
100015231(GAMT)
SHR: 
OAA: 
GGA: 
770737(GAMT)
MGP: 
TGU: 
FAB: 
101818937(GAMT)
PHI: 
102112087(GAMT)
APLA: 
101803779(GAMT)
FPG: 
FCH: 
CLV: 
102093632(GAMT)
ASN: 
AMJ: 
PSS: 
102458769(GAMT)
CMY: 
102941606(GAMT)
ACS: 
XLA: 
380384(gamt-a)
XTR: 
394491(gamt)
DRE: 
796865(gamt)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181936(gamt)
BFO: 
CIN: 
SPU: 
NVE: 
AQU: 
DHA: 
PIC: 
CAL: 
CaO19.8535(RMT2) CaO19.920(RMT2)
 » show all
Taxonomy
Reference
1
  Authors
Cantoni, G.L. and Scarano, E.
  Title
The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions.
  Journal
J. Am. Chem. Soc. 76 (1954) 4744.
Reference
2  [PMID:13192118]
  Authors
CANTONI GL, VIGNOS PJ Jr.
  Title
Enzymatic mechanism of creatine synthesis.
  Journal
J. Biol. Chem. 209 (1954) 647-59.
  Organism
Bos taurus, Sus scofa, Cavia porcellus, Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-75-8

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